Methods for Enhancing Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Homology-Directed Repair Efficiency

CasX enzymes comprise a distinct family of RNA-guided genome editors

(2019) Jun-Jie Liu et al.   NATURE

Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles

(2018) Denise G. Lanza et al.   BMC BIOLOGY

CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo

(2018) Jayme Salsman et al.   CURRENT GENE THERAPY

Transforming plant biology and breeding with CRISPR/Cas9, Cas12 and Cas13

(2018) Patrick Schindele et al.   FEBS LETTERS

Suppressing Ku70/Ku80 expression elevates homology-directed repair efficiency in primary fibroblasts

(2018) Guoling Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synthesis-dependent repair of Cpf1-induced double strand DNA breaks enables targeted gene replacement in rice

(2018) Shaoya Li et al.   JOURNAL OF EXPERIMENTAL BOTANY

Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2018) Trung Van Chu et al.   NATURE BIOTECHNOLOGY

Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase

(2018) Jian Tu et al.   Stem Cell Research

Strategies for In Vivo Genome Editing in Nondividing Cells

(2018) Fatemeharefeh Nami et al.   TRENDS IN BIOTECHNOLOGY

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

(2018) M. Charpentier et al.   Nature Communications

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR–Cas9 and ssODN in human cancer cells

(2018) Zheng Hu et al.   Cell and Bioscience

Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation

(2018) Emilie Ma et al.   eLife

Efficient Knock-in of a Point Mutation in Porcine Fibroblasts Using the CRISPR/Cas9-GMNN Fusion Gene

(2018) Max Gerlach et al.   Genes

Single-Homology-Arm Linear DNA Recombination by the Nonhomologous End Joining Pathway as a Novel and Simple Gene Inactivation Method: a Proof-of-Concept Study in Dietzia sp. Strain DQ12-45-1b

(2018) Shelian Lu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange

(2018) Anaid Benitez et al.   MOLECULAR CELL

RDM1 plays an oncogenic role in human lung adenocarcinoma cells

(2018) Lu Tong et al.   Scientific Reports

The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53

(2018) Vanesa Gottifredi et al.   Cancers

Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9

(2018) Lupeng Ye et al.   Cell Discovery

CRISPR-Cas9 in genome editing: Its function and medical applications

(2018) Saedeh Khadempar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CRISPR/Cas system: A game changing genome editing technology, to treat human genetic diseases

(2018) Wajid Hussain et al.   GENE

Enhancing CRISPR/Cas9-mediated homology-directed repair in mammalian cells by expressing Saccharomyces cerevisiae Rad52

(2017) Simin Shao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

(2017) Nausica Arnoult et al.   NATURE

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria

(2017) Aude Bernheim et al.   Nature Communications

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Maintenance of genome stability by Fanconi anemia proteins

(2017) Anna Palovcak et al.   Cell and Bioscience

Optimizing the DNA Donor Template for Homology-Directed Repair of Double-Strand Breaks

(2017) Fei Song et al.   Molecular Therapy-Nucleic Acids

Non-Homologous End Joining and Homology Directed DNA Repair Frequency of Double-Stranded Breaks Introduced by Genome Editing Reagents

(2017) Michail Zaboikin et al.   PLoS One

Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells

(2017) Guoling Li et al.   Scientific Reports

CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish

(2016) Federico González   DEVELOPMENTAL DYNAMICS

Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA

(2016) Christopher D Richardson et al.   NATURE BIOTECHNOLOGY

The Fanconi anaemia pathway: new players and new functions

(2016) Raphael Ceccaldi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and regulation of the nonsense-mediated decay pathway

(2016) Nele Hug et al.   NUCLEIC ACIDS RESEARCH

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

(2016) F. Jiang et al.   SCIENCE

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

(2016) Tony Gutschner et al.   Cell Reports

Highly efficient CRISPR/HDR-mediated knock-in for mouse embryonic stem cells and zygotes

(2015) Bangmei Wang et al.   BIOTECHNIQUES

SnapShot: Fanconi Anemia and Associated Proteins

(2015) Anderson T. Wang et al.   CELL

Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing

(2015) Supriya V. Vartak et al.   FEBS Journal

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

(2015) James E Dahlman et al.   NATURE BIOTECHNOLOGY

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

(2015) Kathrin Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase η in Recombination-Associated DNA Synthesis at Blocked Replication Forks

(2014) Rémi Buisson et al.   Cell Reports

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

(2014) Steven Lin et al.   eLife

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

(2013) Prashant Mali et al.   NATURE BIOTECHNOLOGY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Targeted gene therapies: tools, applications, optimization

(2012) Olivier Humbert et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair

(2012) J. W. C. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms

(2011) Fenghua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

(2011) Chantal Stoepker et al.   NATURE GENETICS

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

(2011) Gerry P Crossan et al.   NATURE GENETICS

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Enhancement of gene targeting in human cells by intranuclear permeation of the Saccharomyces cerevisiae Rad52 protein

(2010) A. Kalvala et al.   NUCLEIC ACIDS RESEARCH

RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex

(2009) Caryn R. Hale et al.   CELL

Genetic Analysis of Zinc-Finger Nuclease-Induced Gene Targeting in Drosophila

(2009) A. Bozas et al.   GENETICS

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY