CRISPR-Cas9 in genome editing: Its function and medical applications
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
CRISPR-Cas9 in genome editing: Its function and medical applications
Authors
Keywords
-
Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2018-10-26
DOI
10.1002/jcp.27476
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CRISPR-CAS9 GENETIC SCREENS UNCOVER A B CELL RECEPTOR-MYD88 SUPERPATHWAY IN DIFFUSE LARGE B CELL LYMPHOMA
- (2017) R.M. Young et al. HEMATOLOGICAL ONCOLOGY
- Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.
- (2017) Matthew C. Canver et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria
- (2017) Seth L. Shipman et al. NATURE
- Identification of essential genes for cancer immunotherapy
- (2017) Shashank J. Patel et al. NATURE
- In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
- (2017) Robert T. Manguso et al. NATURE
- Correction of a pathogenic gene mutation in human embryos
- (2017) Hong Ma et al. NATURE
- Reconstitution ofUCP1using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity
- (2017) Qiantao Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of the CRISPR genome integration complex
- (2017) Addison V. Wright et al. SCIENCE
- Genome editing abrogates angiogenesis in vivo
- (2017) Xionggao Huang et al. Nature Communications
- p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita
- (2017) Wilson Chun Fok et al. Stem Cell Reports
- In vivo genome editing improves motor function and extends survival in a mouse model of ALS
- (2017) Thomas Gaj et al. Science Advances
- Disabling Cas9 by an anti-CRISPR DNA mimic
- (2017) Jiyung Shin et al. Science Advances
- The Heroes of CRISPR
- (2016) Eric S. Lander CELL
- The Impact of CRISPR/Cas9-Based Genomic Engineering on Biomedical Research and Medicine
- (2016) D.E. Go et al. CURRENT MOLECULAR MEDICINE
- The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
- (2016) Ines Fonfara et al. NATURE
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
- (2016) Daesik Kim et al. NATURE BIOTECHNOLOGY
- Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
- (2016) Shengdar Q. Tsai et al. NATURE REVIEWS GENETICS
- Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
- (2016) F. Jiang et al. SCIENCE
- Sequence features associated with the cleavage efficiency of CRISPR/Cas9 system
- (2016) Xiaoxi Liu et al. Scientific Reports
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Recent developments and clinical studies utilizing engineered zinc finger nuclease technology
- (2015) Young-Il Jo et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing
- (2015) Nicolas Wyvekens et al. HUMAN GENE THERAPY
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
- (2015) Silvana Konermann et al. NATURE
- Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- (2015) Takeshi Maruyama et al. NATURE BIOTECHNOLOGY
- A split-Cas9 architecture for inducible genome editing and transcription modulation
- (2015) Bernd Zetsche et al. NATURE BIOTECHNOLOGY
- Photoactivatable CRISPR-Cas9 for optogenetic genome editing
- (2015) Yuta Nihongaki et al. NATURE BIOTECHNOLOGY
- Small molecule–triggered Cas9 protein with improved genome-editing specificity
- (2015) Kevin M Davis et al. Nature Chemical Biology
- Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
- (2015) Daesik Kim et al. NATURE METHODS
- An updated evolutionary classification of CRISPR–Cas systems
- (2015) Kira S. Makarova et al. NATURE REVIEWS MICROBIOLOGY
- Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
- (2015) Ritambhara Singh et al. NUCLEIC ACIDS RESEARCH
- Rational design of a split-Cas9 enzyme complex
- (2015) Addison V. Wright et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Human Genome Editing and Ethical Considerations
- (2015) Kewal Krishan et al. SCIENCE AND ENGINEERING ETHICS
- Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
- (2015) Xiao-Hui Zhang et al. Molecular Therapy-Nucleic Acids
- A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging
- (2014) Marvin E. Tanenbaum et al. CELL
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
- (2014) Luke A. Gilbert et al. CELL
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells
- (2014) Yuexin Zhou et al. NATURE
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
- (2014) Carolin Anders et al. NATURE
- CRISPR-mediated direct mutation of cancer genes in the mouse liver
- (2014) Wen Xue et al. NATURE
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- CRISPR-Cas systems for editing, regulating and targeting genomes
- (2014) Jeffry D Sander et al. NATURE BIOTECHNOLOGY
- Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
- (2014) John G Doench et al. NATURE BIOTECHNOLOGY
- Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
- (2014) John P Guilinger et al. NATURE BIOTECHNOLOGY
- Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers
- (2014) Xuefei Gao et al. NUCLEIC ACIDS RESEARCH
- Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs
- (2014) James A. Gagnon et al. PLoS One
- Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
- (2014) M. Jinek et al. SCIENCE
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
- (2013) Baohui Chen et al. CELL
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
- (2013) Luke A. Gilbert et al. CELL
- Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
- (2013) Albert W Cheng et al. CELL RESEARCH
- Genome Engineering with TAL-Effector Nucleases and Alternative Modular Nuclease Technologies
- (2013) Andrew Scharenberg et al. CURRENT GENE THERAPY
- CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
- (2013) Prashant Mali et al. NATURE BIOTECHNOLOGY
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
- (2013) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- RNA-guided editing of bacterial genomes using CRISPR-Cas systems
- (2013) Wenyan Jiang et al. NATURE BIOTECHNOLOGY
- CRISPR interference (CRISPRi) for sequence-specific control of gene expression
- (2013) Matthew H Larson et al. Nature Protocols
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
- (2013) David Bikard et al. NUCLEIC ACIDS RESEARCH
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Tunable and Multifunctional Eukaryotic Transcription Factors Based on CRISPR/Cas
- (2013) Fahim Farzadfard et al. ACS Synthetic Biology
- TALENs: a widely applicable technology for targeted genome editing
- (2012) J. Keith Joung et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
- (2011) George Silva et al. CURRENT GENE THERAPY
- The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
- (2010) Josiane E. Garneau et al. NATURE
- RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
- (2009) Caryn R. Hale et al. CELL
- Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
- (2008) S. J. J. Brouns et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started