Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue

Transscleral Delivery of Bevacizumab-Loaded Chitosan Nanoparticles

(2019) Nagihan Ugˇurlu et al.   Journal of Biomedical Nanotechnology

Volcanic ash from Puyehue-Cordón Caulle Volcanic Complex and Calbuco promote a differential response of pro-inflammatory and oxidative stress mediators on human conjunctival epithelial cells

(2018) Agustina I. Tesone et al.   ENVIRONMENTAL RESEARCH

Ocular toxicity of reduced graphene oxide or graphene oxide exposure in mouse eyes

(2018) Wenzhen An et al.   EXPERIMENTAL EYE RESEARCH

The inflammatory response to silver and titanium dioxide nanoparticles in the central nervous system

(2018) Tianshu Wu et al.   Nanomedicine

Investigating oxidation state-induced toxicity of PEGylated graphene oxide in ocular tissue using gene expression profiles

(2018) Wei Wu et al.   Nanotoxicology

Effects of environment pollution on the ocular surface

(2018) Se Ji Jung et al.   Ocular Surface

Trends in Eye Injuries and Associated Medical Costs among Children in the United States, 2002–2014

(2018) Huabin Luo et al.   OPHTHALMIC EPIDEMIOLOGY

Toxicity of silicon dioxide nanoparticles with varying sizes on the cornea and protein corona as a strategy for therapy

(2018) Dayu Sun et al.   Science Bulletin

Ocular Exposures Reported to United States Poison Control Centers

(2018) Alisha Kamboj et al.   OPHTHALMIC EPIDEMIOLOGY

Fullerene nanoparticle in dermatological and cosmetic applications

(2017) S. Zeinab Mousavi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Evaluating nanotechnology opportunities and risks through integration of life-cycle and risk assessment

(2017) Michael P. Tsang et al.   Nature Nanotechnology

Nano-sized iron particles may induce multiple pathways of cell death following generation of mistranscripted RNA in human corneal epithelial cells

(2017) Eun-Jung Park et al.   TOXICOLOGY IN VITRO

Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review

(2017) Rahim Dad Brohi et al.   Frontiers in Pharmacology

Toxicity assessment of nanoparticles in various systems and organs

(2017) Yuan Yang et al.   Nanotechnology Reviews

An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles: Ocular Topical Administration versus Oral Administration

(2017) Martha Kim et al.   Scientific Reports

The effects of nanoparticles on the renal system

(2016) Ivo Iavicoli et al.   CRITICAL REVIEWS IN TOXICOLOGY

External eye symptoms in indoor environments

(2016) P. Wolkoff   INDOOR AIR

Evaluation of the toxicity of graphene oxide exposure to the eye

(2016) Wei Wu et al.   Nanotoxicology

Effect of Titanium Dioxide Nanoparticle Exposure on the Ocular Surface: An Animal Study

(2016) Youngsub Eom et al.   Ocular Surface

Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation

(2016) Alex Langford-Smith et al.   PLoS One

Biocompatibility of gold nanoparticles in retinal pigment epithelial cell line

(2016) Bedia Begüm Karakoçak et al.   TOXICOLOGY IN VITRO

The Effect of Silica Nanoparticles on Human Corneal Epithelial Cells

(2016) Joo-Hee Park et al.   Scientific Reports

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

(2015) Susanne N. Kolle et al.   Particle and Fibre Toxicology

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

(2015) Puja Khanna et al.   Nanomaterials

Role of Physicochemical Properties in Nanoparticle Toxicity

(2015) Seung Shin et al.   Nanomaterials

Defining the Catalytic Activity of Nanoceria in the P23H-1 Rat, a Photoreceptor Degeneration Model

(2015) Lily L. Wong et al.   PLoS One

Lacrimal Cytokines Assessment in Subjects Exposed to Different Levels of Ambient Air Pollution in a Large Metropolitan Area

(2015) Monique Matsuda et al.   PLoS One

Molecular Toxicity of Nanomaterials

(2014) Xue-Ling Chang et al.   Journal of Biomedical Nanotechnology

Anti-angiogenic effect of bare titanium dioxide nanoparticles on pathologic neovascularization without unbearable toxicity

(2014) Dong Hyun Jo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

(2014) David E. Lefebvre et al.   Nanotoxicology

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation

(2014) Hedwig M Braakhuis et al.   Particle and Fibre Toxicology

Silver and Gold Nanoparticles Exposure to In Vitro Cultured Retina – Studies on Nanoparticle Internalization, Apoptosis, Oxidative Stress, Glial- and Microglial Activity

(2014) Erika Söderstjerna et al.   PLoS One

Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan

(2014) Tatsuya Mimura et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Physicochemical Properties of Nanomaterials: Implication in Associated Toxic Manifestations

(2014) Manzoor Ahmad Gatoo et al.   Biomed Research International

Sustained inhibition of neovascularization in vldlr−/− mice following intravitreal injection of cerium oxide nanoparticles and the role of the ASK1-P38/JNK-NF-κB pathway

(2013) Xue Cai et al.   BIOMATERIALS

Cytotoxicity and genotoxicity of multi-walled carbon nanotubes with human ocular cells

(2013) Lu Yan et al.   CHINESE SCIENCE BULLETIN

Zinc oxide nanoparticles decrease the expression and activity of plasma membrane calcium ATPase, disrupt the intracellular calcium homeostasis in rat retinal ganglion cells

(2013) Dadong Guo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Zinc Oxide Nanoparticles Induce Rat Retinal Ganglion Cell Damage Through Bcl-2, Caspase-9 and Caspase-12 Pathways

(2013) Dadong Guo et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Anatomy of Secretory Glands in the Eyelid and Conjunctiva

(2013) Yasuhiro Takahashi et al.   OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY

Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection

(2013) Lily L. Wong et al.   PLoS One

Gold Nanoparticles Disrupt Zebrafish Eye Development and Pigmentation

(2013) Ki-Tae Kim et al.   TOXICOLOGICAL SCIENCES

Retinal iron homeostasis in health and disease

(2013) Delu Song et al.   Frontiers in Aging Neuroscience

Is Household Air Pollution a Risk Factor for Eye Disease?

(2013) Sheila West et al.   International Journal of Environmental Research and Public Health

Sunlight-Induced Reduction of Ionic Ag and Au to Metallic Nanoparticles by Dissolved Organic Matter

(2012) Yongguang Yin et al.   ACS Nano

Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria

(2012) Xue Cai et al.   BIOMATERIALS

Can Graphene Oxide Cause Damage to Eyesight?

(2012) Lu Yan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

DNA Damage Caused by Metal Nanoparticles: Involvement of Oxidative Stress and Activation of ATM

(2012) Rong Wan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Dermal and ocular irritation and skin sensitization studies of fullerene C60nanoparticles

(2012) Makoto Ema et al.   Cutaneous and Ocular Toxicology

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Human health hazards of persistent inorganic and carbon nanoparticles

(2012) L. Reijnders   JOURNAL OF MATERIALS SCIENCE

Genotoxicity, acute oral and dermal toxicity, eye and dermal irritation and corrosion and skin sensitisation evaluation of silver nanoparticles

(2012) Jin Sik Kim et al.   Nanotoxicology

Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells

(2012) Dadong Guo et al.   TOXICOLOGY IN VITRO

Generation of Metal Nanoparticles from Silver and Copper Objects: Nanoparticle Dynamics on Surfaces and Potential Sources of Nanoparticles in the Environment

(2011) Richard D. Glover et al.   ACS Nano

Ocular surface adverse effects of ambient levels of air pollution

(2011) André Augusto Miranda Torricelli et al.   ARQUIVOS BRASILEIROS DE OFTALMOLOGIA

In Vitro Evaluation of Cellular Response Induced by Manufactured Nanoparticles

(2011) Masanori Horie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS

Silver Nanoparticles and Total Aerosols Emitted by Nanotechnology-Related Consumer Spray Products

(2011) Marina E. Quadros et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Neutrophilic Inflammatory Response and Oxidative Stress in Premenopausal Women Chronically Exposed to Indoor Air Pollution from Biomass Burning

(2011) Anirban Banerjee et al.   INFLAMMATION

Loss of Daylight Vision in Retinal Degeneration: Are Oxidative Stress and Metabolic Dysregulation to Blame?

(2011) Claudio Punzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Evaluation of Acute Toxicity of Colloidal Silver Nanoparticles

(2011) Pattwat MANEEWATTANAPINYO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Release profile and transscleral permeation of triamcinolone acetonide loaded nanostructured lipid carriers (TA-NLC): in vitro and ex vivo studies

(2011) Joana Araújo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Surface charge of gold nanoparticles mediates mechanism of toxicity

(2011) Nicole M. Schaeublin et al.   Nanoscale

Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers

(2011) Anne Thoustrup Saber et al.   Nanotoxicology

Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways

(2011) Li Kong et al.   NEUROBIOLOGY OF DISEASE

The neurotoxic potential of engineered nanomaterials

(2011) William K. Boyes et al.   NEUROTOXICOLOGY

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

(2011) Wan-Seob Cho et al.   Particle and Fibre Toxicology

Nanoceria Inhibit the Development and Promote the Regression of Pathologic Retinal Neovascularization in the Vldlr Knockout Mouse

(2011) Xiaohong Zhou et al.   PLoS One

Evaluation of Magnetic Micro- and Nanoparticle Toxicity to Ocular Tissues

(2011) Hemalatha B. Raju et al.   PLoS One

Graphene based materials: Past, present and future

(2011) Virendra Singh et al.   PROGRESS IN MATERIALS SCIENCE

Evaluation of dermal and eye irritation and skin sensitization due to carbon nanotubes

(2011) Makoto Ema et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles

(2010) Atul Asati et al.   ACS Nano

A look at autoimmunity and inflammation in the eye

(2010) Rachel R. Caspi   JOURNAL OF CLINICAL INVESTIGATION

A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment

(2010) Catalina Marambio-Jones et al.   JOURNAL OF NANOPARTICLE RESEARCH

Nanomaterials and regulation of cosmetics

(2010) Diana M Bowman et al.   Nature Nanotechnology

Human safety review of “nano” titanium dioxide and zinc oxide

(2010) Karsten Schilling et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Acute Cardiovascular and Inflammatory Toxicity Induced by Inhalation of Diesel and Biodiesel Exhaust Particles

(2010) Jôse Mára Brito et al.   TOXICOLOGICAL SCIENCES

Antiangiogenic properties of silver nanoparticles

(2009) Sangiliyandi Gurunathan et al.   BIOMATERIALS

Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells

(2009) Kalimuthu Kalishwaralal et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Minireview: Nanoparticles and the Immune System

(2009) Banu S. Zolnik et al.   ENDOCRINOLOGY

Phakic intraocular lenses

(2009) Rajesh Sinha et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs

(2009) PARESH CHANDRA RAY et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology

(2009) G. Oberdörster   JOURNAL OF INTERNAL MEDICINE

Nanoparticles and the Brain: Cause for Concern?

(2009) Günter Oberdörster et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Safety evaluation of highly purified fullerenes (HPFs): based on screening of eye and skin damage

(2009) Hisae Aoshima et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Nanoceria have no genotoxic effect on human lens epithelial cells

(2009) Barbara K Pierscionek et al.   NANOTECHNOLOGY

Intravenously administered gold nanoparticles pass through the blood–retinal barrier depending on the particle size, and induce no retinal toxicity

(2009) Jeong Hun Kim et al.   NANOTECHNOLOGY

Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective

(2009) Mélanie Auffan et al.   Nature Nanotechnology

Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

(2009) Nicklas Jacobsen et al.   Particle and Fibre Toxicology

Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide

(2009) Tina M Sager et al.   Particle and Fibre Toxicology

ABSENCE OF HISTOLOGIC RETINAL TOXICITY OF INTRAVITREAL NANOGOLD IN A RABBIT MODEL

(2009) SOPHIE J. BAKRI et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods

(2009) A. Sairam Kishore et al.   TOXICOLOGY LETTERS

Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells

(2009) Sardarpasha Sheikpranbabu et al.   JOURNAL OF NANOBIOTECHNOLOGY

Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies

(2008) Jingkun Jiang et al.   JOURNAL OF NANOPARTICLE RESEARCH

Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area

(2008) Tina M Sager et al.   Particle and Fibre Toxicology

Nanotechnology, nanotoxicology, and neuroscience

(2008) Won Hyuk Suh et al.   PROGRESS IN NEUROBIOLOGY

The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line

(2008) Martin J.D. Clift et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Indoor air pollution from biomass fuel smoke is a major health concern in the developing world

(2008) Duncan G. Fullerton et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE