Loss of Daylight Vision in Retinal Degeneration: Are Oxidative Stress and Metabolic Dysregulation to Blame?

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo

(2011) James J. Cronican et al.   CHEMISTRY & BIOLOGY

Overexpression of SOD in retina: Need for increase in H2O2-detoxifying enzyme in same cellular compartment

(2011) Shinichi Usui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of Glucose in Photoreceptor Survival

(2011) Andrei O. Chertov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Evidence for Lactate as a Neuronal Energy Source

(2011) M. T. Wyss et al.   JOURNAL OF NEUROSCIENCE

Concise Review: Making a Retina-From the Building Blocks to Clinical Applications

(2011) Valerie A. Wallace   STEM CELLS

Induction of Rapid and Highly Efficient Expression of the Human ND4 Complex I Subunit in the Mouse Visual System by Self-complementary Adeno-Associated Virus

(2010) Rajeshwari D. Koilkonda   ARCHIVES OF OPHTHALMOLOGY

Enhanced Retinal Insulin Receptor-activated Neuroprotective Survival Signal in Mice Lacking the Protein-tyrosine Phosphatase-1B Gene

(2010) Raju V. S. Rajala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stemming vision loss with stem cells

(2010) Valentina Marchetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Rhodopsin-regulated Insulin Receptor Signaling Pathway in Rod Photoreceptor Neurons

(2010) Raju V. S. Rajala et al.   MOLECULAR NEUROBIOLOGY

POD Nanoparticles Expressing GDNF Provide Structural and Functional Rescue of Light-induced Retinal Degeneration in an Adult Mouse

(2010) Sarah P Read et al.   MOLECULAR THERAPY

Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis Pigmentosa

(2010) Ji-jing Pang et al.   MOLECULAR THERAPY

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait

(2010) Alan F. Wright et al.   NATURE REVIEWS GENETICS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phagocytosis of Retinal Rod and Cone Photoreceptors

(2010) Brian M. Kevany et al.   PHYSIOLOGY

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

(2010) V. Busskamp et al.   SCIENCE

Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse

(2009) T K Park et al.   GENE THERAPY

Adeno-Associated Virus-Mediated Rhodopsin Replacement Provides Therapeutic Benefit in Mice with a Targeted Disruption of the Rhodopsin Gene

(2009) Arpad Palfi et al.   HUMAN GENE THERAPY

NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa

(2009) Shinichi Usui et al.   JOURNAL OF NEUROCHEMISTRY

Improved Retinal Function in a Mouse Model of Dominant Retinitis Pigmentosa Following AAV-delivered Gene Therapy

(2009) Naomi Chadderton et al.   MOLECULAR THERAPY

Functional Cone Rescue by RdCVF Protein in a Dominant Model of Retinitis Pigmentosa

(2009) Ying Yang et al.   MOLECULAR THERAPY

Increased Expression of Catalase and Superoxide Dismutase 2 Reduces Cone Cell Death in Retinitis Pigmentosa

(2009) Shinichi Usui et al.   MOLECULAR THERAPY

A Partial Structural and Functional Rescue of a Retinitis Pigmentosa Model with Compacted DNA Nanoparticles

(2009) Xue Cai et al.   PLoS One

Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function

(2009) M. Haruta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

(2009) B. Chen et al.   SCIENCE

Increased Expression of Glutathione Peroxidase 4 Strongly Protects Retina from Oxidative Damage

(2008) Lili Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

ATP Consumption by Mammalian Rod Photoreceptors in Darkness and in Light

(2008) Haruhisa Okawa et al.   CURRENT BIOLOGY

Remodeling of cone photoreceptor cells after rod degeneration in rd mice

(2008) Bin Lin et al.   EXPERIMENTAL EYE RESEARCH

Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells

(2008) Ammaji Rajala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subfunctionalization of a Retinoid-Binding Protein Provides Evidence for Two Parallel Visual Cycles in the Cone-Dominant Zebrafish Retina

(2008) V. C. Fleisch et al.   JOURNAL OF NEUROSCIENCE

Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration

(2008) Pamela S Lagali et al.   NATURE NEUROSCIENCE

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE

Mitochondrial Dysfunction in Neurodegenerative Diseases

(2008) Anthony H. V. Schapira   NEUROCHEMICAL RESEARCH

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly efficient retinal metabolism in cones

(2008) S. Miyazono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin

(2008) B. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cone-specific expression using a human red opsin promoter in recombinant AAV

(2007) Qiuhong Li et al.   VISION RESEARCH