Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors

2-Imino-thiazolidin-4-one Derivatives as Potent, Orally Active S1P1Receptor Agonists

(2010) Martin H. Bolli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingosine 1-Phosphate (S1P) Regulates Vascular Contraction via S1P3 Receptor: Investigation Based on a New S1P3 Receptor Antagonist

(2010) A. Murakami et al.   MOLECULAR PHARMACOLOGY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Structure-based drug design identifies novel LPA3 antagonists

(2009) James I. Fells et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

(2009) Honglu Zhang et al.   CANCER RESEARCH

Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from Ascotricha chartarum Berk. SANK 14186

(2009) Kiyoaki Yonesu et al.   JOURNAL OF ANTIBIOTICS

Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood

(2009) Tomoko Endo et al.   JOURNAL OF BIOCHEMISTRY

Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

(2009) Keisuke Yanagida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Ligand Selectivity of the GPR92/LPA5Lysophosphatidate Receptor Indicates Role in Human Platelet Activation

(2009) Jesica R. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-Binding Pocket Shape Differences between Sphingosine 1-Phosphate (S1P) Receptors S1P1and S1P3Determine Efficiency of Chemical Probe Identification by Ultrahigh-Throughput Screening

(2008) Stephan C. Schürer et al.   ACS Chemical Biology

Identification of the orphan GPCR, P2Y10 receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor

(2008) Masanori Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog

(2008) Kiyoaki Yonesu et al.   BIOCHEMICAL PHARMACOLOGY

Phosphatase-resistant analogues of lysophosphatidic acid: Agonists promote healing, antagonists and autotaxin inhibitors treat cancer

(2008) G PRESTWICH   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification of non-lipid LPA3 antagonists by virtual screening

(2008) James I. Fells et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lysophosphatidic acid (LPA) and its receptors

(2008) Kyoko Noguchi et al.   CURRENT OPINION IN PHARMACOLOGY

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

(2008) Sergio Caballero et al.   EXPERIMENTAL EYE RESEARCH

Identification of Farnesyl Pyrophosphate andN-Arachidonylglycine as Endogenous Ligands for GPR92

(2008) Da Young Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophospholipid receptors in vertebrate development, physiology, and pathology

(2008) Athanasia Skoura et al.   JOURNAL OF LIPID RESEARCH

Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions

(2008) P. J. Gonzalez-Cabrera et al.   MOLECULAR PHARMACOLOGY

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

(2008) Sandra M Pasternack et al.   NATURE GENETICS