Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1

Different apoptotic effects of saxifragifolin C in human breast cancer cells

(2016) Kyung-Ho Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells

(2016) Cláudia M. Deus et al.   ARCHIVES OF TOXICOLOGY

The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer

(2016) E. Latorre et al.   CANCER RESEARCH

O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway

(2016) C M Ferrer et al.   ONCOGENE

ROS and energy metabolism in cancer cells: alliance for fast growth

(2015) Sang Won Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer

(2015) Soo Young Chung et al.   CLINICAL & EXPERIMENTAL METASTASIS

Redox Regulation in Cancer Stem Cells

(2015) Shijie Ding et al.   Oxidative Medicine and Cellular Longevity

Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

(2015) Paweorn Angsutararux et al.   Oxidative Medicine and Cellular Longevity

Long Term Exposure to Polyphenols of Artichoke (Cynara scolymusL.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line

(2015) Anna Maria Mileo et al.   Oxidative Medicine and Cellular Longevity

Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a′]diisoquinoline derivatives in human breast cancer cells

(2014) Monika Lepiarczyk et al.   ARCHIVES OF PHARMACAL RESEARCH

Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft

(2014) Wei-Jiunn Lee et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial alterations in apoptosis

(2014) Katia Cosentino et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Effect of evodiagenine mediates photocytotoxicity on human breast cancer cells MDA-MB-231 through inhibition of PI3K/AKT/mTOR and activation of p38 pathways

(2014) Changliang Xu et al.   FITOTERAPIA

The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation

(2014) Li Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways

(2013) Jing Wang et al.   APOPTOSIS

Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways

(2013) Azhar Rasul et al.   ARCHIVES OF PHARMACAL RESEARCH

Redox-regulating sirtuins in aging, caloric restriction, and exercise

(2013) Zsolt Radak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isoalantolactone Inhibits UM-SCC-10A Cell Growth via Cell Cycle Arrest and Apoptosis Induction

(2013) Minjun Wu et al.   PLoS One

A Trojan Horse in Drug Development: Targeting of Thapsigargins Towards Prostate Cancer Cells

(2012) S. Christensen et al.   Anti-Cancer Agents in Medicinal Chemistry

N-Benzoyl-12-nitrodehydroabietylamine-7-one, a novel dehydroabietylamine derivative, induces apoptosis and inhibits proliferation in HepG2 cells

(2012) Ling-Ying Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells

(2012) Muhammad Khan et al.   International Journal of Biological Sciences

Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation

(2012) Raffaele Frazzi et al.   INTERNATIONAL JOURNAL OF CANCER

Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction

(2012) Muhammad Khan et al.   IUBMB LIFE

Synaptic and nonsynaptic mitochondria demonstrate a different degree of calcium-induced mitochondrial dysfunction

(2012) Chontida Yarana et al.   LIFE SCIENCES

Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer

(2011) Naoko Okumura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antistaphylococcal activity of Inula helenium L. root essential oil: eudesmane sesquiterpene lactones induce cell membrane damage

(2011) Z. Stojanović-Radić et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells

(2010) Arunasree M. Kalle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

What made sesquiterpene lactones reach cancer clinical trials?

(2010) Akram Ghantous et al.   DRUG DISCOVERY TODAY

Focal adhesion kinase: A prominent determinant in breast cancer initiation, progression and metastasis

(2009) Ming Luo et al.   CANCER LETTERS

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions

(2009) Y.N. V. Gopal et al.   MOLECULAR CANCER THERAPEUTICS

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

(2008) Brittney Jung-Hynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY