O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway

A little sugar goes a long way: The cell biology of O-GlcNAc

(2015) Michelle R. Bond et al.   JOURNAL OF CELL BIOLOGY

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer

(2015) V. L. Sodi et al.   MOLECULAR CANCER RESEARCH

Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling

(2015) Yong Ryoul Yang et al.   Oncotarget

Sirtuins, metabolism, and DNA repair

(2014) Jee-Eun Choi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

O-GlcNAc and the Epigenetic Regulation of Gene Expression

(2014) Brian A. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between Two Essential Nutrient-sensitive Enzymes

(2014) John W. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

(2014) Christina M. Ferrer et al.   MOLECULAR CELL

Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD+-dependent deacetylases

(2014) F Yeung et al.   ONCOGENE

A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity

(2014) P K Bajpe et al.   ONCOGENE

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

(2013) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorting out functions of sirtuins in cancer

(2013) M Roth et al.   ONCOGENE

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

(2012) Yong Ryoul Yang et al.   AGING CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Critical Role ofO-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

(2012) Thomas P. Lynch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXM1: From cancer initiation to progression and treatment

(2011) Chuay-Yeng Koo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

(2011) Wenyi Mi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

O-GlcNAc transferase: A sweet new cancer target

(2011) Thomas P. Lynch et al.   CELL CYCLE

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation

(2011) Qianqian Zhu et al.   MEDICAL ONCOLOGY

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells

(2011) Gabriel T. M. Lok et al.   PLoS One

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis

(2010) Y. Gu et al.   CANCER RESEARCH

ErbB2 requires integrin  5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells

(2010) K. K. Haenssen et al.   JOURNAL OF CELL SCIENCE

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress

(2009) Chutikarn Butkinaree et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

(2009) Tong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats

(2008) Norbert Fülöp et al.   BIOGERONTOLOGY

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Proteolysis of the Forkhead Box M1 Transcription Factor Is Critical for Regulated Entry into S Phase

(2008) H. J. Park et al.   MOLECULAR AND CELLULAR BIOLOGY

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One