Speculative strategies for new antibacterials: all roads should not lead to Rome
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Title
Speculative strategies for new antibacterials: all roads should not lead to Rome
Authors
Keywords
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Journal
JOURNAL OF ANTIBIOTICS
Volume 66, Issue 7, Pages 371-386
Publisher
Springer Nature
Online
2013-04-24
DOI
10.1038/ja.2013.27
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- (2013) Brian W. Kwan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2012) Jun-Jie Li et al. BMC INFECTIOUS DISEASES
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- (2012) Mohammad Adnan Syed et al. CANADIAN JOURNAL OF MICROBIOLOGY
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- (2012) J. M. Paterson et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
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- (2012) Matthew B. Nodwell et al. CHEMBIOCHEM
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- (2012) Anna-Winona Struck et al. CHEMBIOCHEM
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- High-Dose, Extended-Interval Colistin Administration in Critically Ill Patients: Is This the Right Dosing Strategy? A Preliminary Study
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- (2012) Phillip J. Bergen et al. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: An update
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- Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?
- (2012) Qinglin Du et al. International Journal of Biological Sciences
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- (2012) B. Gu et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- 2012 and beyond: potential for the start of a second pre-antibiotic era?
- (2012) P. C. Appelbaum JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens
- (2012) M. Vaara et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Design and Synthesis of Potential Mechanism-Based Inhibitors of the Aminotransferase BioA Involved in Biotin Biosynthesis
- (2012) Ce Shi et al. JOURNAL OF ORGANIC CHEMISTRY
- YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli
- (2012) Hisako Masuda et al. MOLECULAR MICROBIOLOGY
- A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS
- (2012) Xiaoxue Wang et al. Nature Chemical Biology
- Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells
- (2012) Marie-Paule Mingeot-Leclercq et al. PEPTIDES
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- (2012) Shelly C. Lu et al. PHYSIOLOGICAL REVIEWS
- The toxin-antitoxin systemtisB-istR1
- (2012) E. Gerhart H. Wagner et al. RNA Biology
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- (2012) Julia J. Williams et al. TRENDS IN MICROBIOLOGY
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- (2012) Anisha Ambady et al. TUBERCULOSIS
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- (2011) Yoshihiro Yamaguchi et al. NATURE REVIEWS MICROBIOLOGY
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- (2011) Garima Khare et al. PLoS One
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- The Riboflavin analog Roseoflavin targets an FMN-riboswitch and blocksListeria monocytogenes growth, but also stimulates virulence gene-expression and infection
- (2011) Mikael Mansjö et al. RNA Biology
- Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression
- (2011) Sae Woong Park et al. PLoS Pathogens
- Persister Cells
- (2010) Kim Lewis Annual Review of Microbiology
- Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: Novel antibacterial agents against Mycobacterium tuberculosis
- (2010) Xiaokai Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus
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- The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020
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- Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides
- (2010) Y. Zhou et al. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance
- (2010) Varvara Pokrovskaya et al. Expert Opinion on Drug Discovery
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- (2010) Jun-Ichi Wachino et al. FEMS MICROBIOLOGY LETTERS
- Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice
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- (2010) D. M. Livermore et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
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- (2010) M. D. Spalding et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Abundance of type I toxin–antitoxin systems in bacteria: searches for new candidates and discovery of novel families
- (2010) Elizabeth M. Fozo et al. NUCLEIC ACIDS RESEARCH
- Characterization of the Interaction and Cross-Regulation of Three Mycobacterium tuberculosis RelBE Modules
- (2010) Min Yang et al. PLoS One
- Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action
- (2010) J. A. Dunkle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Revisiting the structures of several antibiotics bound to the bacterial ribosome
- (2010) D. Bulkley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array
- (2010) V. L. Arcus et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression
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- (2010) Tobias Dörr et al. PLOS BIOLOGY
- Novel heterodimer antibiotics: a review of recent patent literature
- (2009) Daniel D Long et al. Future Medicinal Chemistry
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- (2009) Daniel D Long et al. JOURNAL OF ANTIBIOTICS
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- (2009) F. E. A. Ali et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Design, Synthesis, and Evaluation of Novel Fluoroquinolone−Aminoglycoside Hybrid Antibiotics
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- Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution
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