Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation

(2018) Robbert Hoogeboom et al.   Cell Reports

The Rap1-cofilin pathway coordinates actin reorganization and MTOC polarization at the B-cell immune synapse

(2017) Jia C. Wang et al.   JOURNAL OF CELL SCIENCE

Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome

(2017) Fabio Candotti   JOURNAL OF CLINICAL IMMUNOLOGY

Changes in E-cadherin rigidity sensing regulate cell adhesion

(2017) Caitlin Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Communication at the Immunological Synapse

(2017) Roshni Basu et al.   TRENDS IN CELL BIOLOGY

Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

(2017) Walter H. A. Kahr et al.   Nature Communications

Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking

(2017) Ye Zhang et al.   Scientific Reports

Limitations of Qdot labelling compared to directly-conjugated probes for single particle tracking of B cell receptor mobility

(2017) Libin Abraham et al.   Scientific Reports

Architecture and Connectivity Govern Actin Network Contractility

(2016) Hajer Ennomani et al.   CURRENT BIOLOGY

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse

(2016) Sricharan Murugesan et al.   JOURNAL OF CELL BIOLOGY

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

(2016) Katelyn M. Spillane et al.   JOURNAL OF CELL BIOLOGY

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

Internetwork competition for monomers governs actin cytoskeleton organization

(2016) Cristian Suarez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling

(2015) F. Gasparrini et al.   EMBO JOURNAL

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells

(2015) Selina Jessica Keppler et al.   IMMUNITY

Cytoskeletal dynamics: A view from the membrane

(2015) Magdalena Bezanilla et al.   JOURNAL OF CELL BIOLOGY

A general method to improve fluorophores for live-cell and single-molecule microscopy

(2015) Jonathan B Grimm et al.   NATURE METHODS

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

(2015) Spencer A. Freeman et al.   Nature Communications

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

(2015) Zhengpeng Wan et al.   eLife

Ligand Mobility Regulates B Cell Receptor Clustering and Signaling Activation

(2014) Christina Ketchum et al.   BIOPHYSICAL JOURNAL

Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity

(2014) Marianne Burbage et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Through an ITIM-Independent Mechanism the Fc RIIB Blocks B Cell Activation by Disrupting the Colocalized Microclustering of the B Cell Receptor and CD19

(2014) L. Xu et al.   JOURNAL OF IMMUNOLOGY

Objective comparison of particle tracking methods

(2014) Nicolas Chenouard et al.   NATURE METHODS

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

(2014) Stephanie Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation

(2013) Wenxia Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

T cell antigen receptor activation and actin cytoskeleton remodeling

(2013) Sudha Kumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

Controversy and consensus regarding myosin II function at the immunological synapse

(2013) John A Hammer et al.   CURRENT OPINION IN IMMUNOLOGY

Multiple Hypothesis Tracking for Cluttered Biological Image Sequences

(2013) N. Chenouard et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

(2013) Pieta K. Mattila et al.   IMMUNITY

B Cell Activation Is Regulated by the Stiffness Properties of the Substrate Presenting the Antigens

(2013) Z. Wan et al.   JOURNAL OF IMMUNOLOGY

Instant super-resolution imaging in live cells and embryos via analog image processing

(2013) Andrew G York et al.   NATURE METHODS

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling

(2013) Chaohong Liu et al.   PLOS BIOLOGY

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

(2012) Qing Yang et al.   JOURNAL OF CELL BIOLOGY

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Actin Reorganization Is Required for the Formation of Polarized B Cell Receptor Signalosomes in Response to Both Soluble and Membrane-Associated Antigens

(2012) C. Liu et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Icy: an open bioimage informatics platform for extended reproducible research

(2012) Fabrice de Chaumont et al.   NATURE METHODS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse

(2012) Sudha Kumari et al.   Frontiers in Immunology

Building Distinct Actin Filament Networks in a Common Cytoplasm

(2011) Alphée Michelot et al.   CURRENT BIOLOGY

B Cell Receptor-Mediated Antigen Gathering Requires Ubiquitin Ligase Cbl and Adaptors Grb2 and Dok-3 to Recruit Dynein to the Signaling Microcluster

(2011) Tim Schnyder et al.   IMMUNITY

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

(2011) Akiko Hashimoto-Tane et al.   IMMUNITY

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity

(2011) Bebhinn Treanor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Balance of Bruton's Tyrosine Kinase and SHIP Activation Regulates B Cell Receptor Cluster Formation by Controlling Actin Remodeling

(2011) C. Liu et al.   JOURNAL OF IMMUNOLOGY

Cofilin-Mediated F-Actin Severing Is Regulated by the Rap GTPase and Controls the Cytoskeletal Dynamics That Drive Lymphocyte Spreading and BCR Microcluster Formation

(2011) S. A. Freeman et al.   JOURNAL OF IMMUNOLOGY

Early Events in B Cell Activation

(2010) Naomi E. Harwood et al.   Annual Review of Immunology

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

(2010) Lisa S. Westerberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Statistics of camera-based single-particle tracking

(2010) Andrew J. Berglund   PHYSICAL REVIEW E

The Cytoskeleton Coordinates the Early Events of B-cell Activation

(2010) N. E. Harwood et al.   Cold Spring Harbor Perspectives in Biology

Microsignalosomes: spatially resolved receptor signalling

(2009) Bebhinn Treanor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Syk and pTyr'd: Signaling through the B cell antigen receptor

(2009) Robert L. Geahlen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Myosin-IIA and ICAM-1 Regulate the Interchange between Two Distinct Modes of T Cell Migration

(2009) J. Jacobelli et al.   JOURNAL OF IMMUNOLOGY

Biogenesis of secretory organelles during B cell differentiation

(2009) Semra J. Kirk et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neuronal IP3 3-Kinase is an F-actin–bundling Protein: Role in Dendritic Targeting and Regulation of Spine Morphology

(2009) Hong W. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

T cell antigen receptor signaling and immunological synapse stability require myosin IIA

(2009) Tal Ilani et al.   NATURE IMMUNOLOGY

The Rap GTPases Regulate B Cell Morphology, Immune-Synapse Formation, and Signaling by Particulate B Cell Receptor Ligands

(2008) Kevin B.L. Lin et al.   IMMUNITY

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

(2008) Michele Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes

(2008) Susan M. Nicholson-Dykstra et al.   CELL MOTILITY AND THE CYTOSKELETON