Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease

(2018) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions

(2017) Maria Larrosa-Garcia et al.   MOLECULAR CANCER THERAPEUTICS

The target landscape of clinical kinase drugs

(2017) Susan Klaeger et al.   SCIENCE

Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

(2017) Jessica Mira Gabin et al.   Alzheimers Research & Therapy

The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior

(2017) Florian Weinberg et al.   EBioMedicine

Progress towards a public chemogenomic set for protein kinases and a call for contributions

(2017) David H. Drewry et al.   PLoS One

Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound–Kinase Activities: A Way toward Selective Promiscuity by Design?

(2016) Serge Christmann-Franck et al.   Journal of Chemical Information and Modeling

Profiling Prediction of Kinase Inhibitors: Toward the Virtual Assay

(2016) Benjamin Merget et al.   JOURNAL OF MEDICINAL CHEMISTRY

Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing

(2016) Hansaim Lim et al.   PLoS Computational Biology

Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy

(2016) Lucie Heinzerling et al.   Journal for ImmunoTherapy of Cancer

Bruton's tyrosine kinase inhibitors in B-cell non-Hodgkin's lymphomas

(2015) L Alinari et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

AutoDockFR: Advances in Protein-Ligand Docking with Explicitly Specified Binding Site Flexibility

(2015) Pradeep Anand Ravindranath et al.   PLoS Computational Biology

Molecular Pathways: Resistance to Kinase Inhibitors and Implications for Therapeutic Strategies

(2014) C. M. Lovly et al.   CLINICAL CANCER RESEARCH

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein kinase inhibitors against malignant lymphoma

(2013) Osmond J D'Cruz et al.   EXPERT OPINION ON PHARMACOTHERAPY

Metrics other than potency reveal systematic variation in responses to cancer drugs

(2013) Mohammad Fallahi-Sichani et al.   Nature Chemical Biology

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Systems Pharmacology of Adverse Event Mitigation by Drug Combinations

(2013) S. Zhao et al.   Science Translational Medicine

Raloxifene attenuates Pseudomonas aeruginosa pyocyanin production and virulence

(2012) Shannan J. Ho Sui et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Human RioK3 is a novel component of cytoplasmic pre-40S pre-ribosomal particles

(2012) Kamila Baumas et al.   RNA Biology

Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs

(2011) Lei Xie et al.   Annual Review of Pharmacology and Toxicology

The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits

(2011) Barbara Widmann et al.   MOLECULAR BIOLOGY OF THE CELL

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir

(2011) Li Xie et al.   PLoS Computational Biology

A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology

(2010) Jacob D. Durrant et al.   PLoS Computational Biology

Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

(2010) Roger L. Chang et al.   PLoS Computational Biology

A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery

(2009) L. Xie et al.   BIOINFORMATICS

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

(2009) Sarah L. Kinnings et al.   PLoS Computational Biology

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

(2009) Li Xie et al.   PLoS Computational Biology

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments

(2008) L. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA