Review
Chemistry, Analytical
Guangze Yang, Yun Liu, Jisi Teng, Chun-Xia Zhao
Summary: The use of fluorescence labelling is common for tracking nanoparticles in drug delivery, but quantification can be challenging due to various factors. Forster resonance energy transfer (FRET) provides a distance ruler for probing NP drug delivery by utilizing energy transfer between donor and acceptor fluorophores. Different FRET approaches discussed in the article offer insights into the design of improved nanoparticles with controlled properties.
Article
Pharmacology & Pharmacy
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Immunology
Ramon Gonzalez-Rioja, Vivian A. Salazar, Neus G. Bastus, Victor Puntes
Summary: Researchers have developed ionizable lipid nanoparticles (iLNPs) as a universal carrier for efficient drug delivery. These iLNPs are formed by electrostatic aggregation of surfactants, therapeutic agents, and lipids, resulting in nanoparticles stabilized with lipid polymers. They have overcome previous limitations and offer advantages such as low toxicity and entry into cells via endocytosis. iLNPs have the potential to greatly improve disease management and are widely available for clinical use.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Samila Horst Peczek, Ana Paula Santos Tartari, Isabella Camargo Zittlau, Camila Diedrich, Christiane Schineider Machado, Rubiana Mara Mainardes
Summary: This study developed nanostructured lipid carriers (NLCs) loaded with perillyl alcohol (POH) to improve its distribution in the brain. The results showed significantly enhanced oral bioavailability of POH when encapsulated in the NLCs, with increased concentration in brain tissue. This provides a potential therapeutic strategy for brain tumor treatment.
Review
Engineering, Biomedical
Bianka Golba, Edmondo M. Benetti, Bruno G. De Geest
Summary: Cyclic polymers, lacking chain ends, possess unique architecture and properties that make them suitable for various applications in nano-, micro-, and macro-scale materials. In the biomedical field, biomaterials based on cyclic polymers demonstrate distinct properties in terms of drug delivery efficiency and surface activity. Future challenges in utilizing cyclic polymers in biomedical applications are also discussed in this review.
Article
Pharmacology & Pharmacy
Marites P. Melancon, Steven Yevich, Rony Avritscher, Adam Swigost, Linfeng Lu, Li Tian, Jossana A. Damasco, Katherine Dixon, Andrea C. Cortes, Nina M. Munoz, Dong Liang, David Liu, Alda L. Tam
Summary: A novel nanoemulsion combining irinotecan with lipiodol showed higher irinotecan deposition in the liver via TACE and more irinotecan distribution in the tumor via PVCE compared to traditional delivery methods, demonstrating promising potential for the treatment of metastatic colorectal cancer.
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Review
Chemistry, Multidisciplinary
Jun Wang, Jing Liu, Zhongxing Yang
Summary: The article discusses the potential of hypoxia as a therapeutic target and the use of peptides for targeting hypoxic diseases. It highlights three main strategies for targeting hypoxia using peptide-based nanomaterials and emphasizes the advantages of peptides in treatment and diagnosis processes.
NANOSCALE ADVANCES
(2021)
Article
Chemistry, Analytical
Juliang Yang, Jing-Jing Hu, Jiaming Wei, Jun Dai, Hao Fang, Fan Xia, Xiaoding Lou
Summary: This study designed an enzyme-responsive modular peptide probe to improve the mitochondrial delivery efficiency and optimize image-guided therapeutic outcomes by regulating the intracellular delivery pathways. The system also shows potential for delivering siRNA and doxorubicin for precise cancer image-guided therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Juliang Yang, Jing-Jing Hu, Jiaming Wei, Jun Dai, Hao Fang, Fan Xia, Xiaoding Lou
Summary: In this study, an enzyme-responsive modular peptide probe was designed to improve the delivery efficiency of therapeutic cargos to the mitochondria. By changing the endocytic pathway, the probe directly reached the mitochondrial sites without passing through the lysosomes, optimizing the image-guided therapeutic efficiency. This system also showed potential for delivering siRNA and doxorubicin for precise cancer image-guided therapy, facilitating the development of personalized therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Faizah S. Aljohani, Moaaz T. Hamed, Basant A. Bakr, Yahya H. Shahin, Marwa M. Abu-Serie, Ashraf K. Awaad, Hadir El-Kady, Bassma H. Elwakil
Summary: The study successfully synthesized highly pure and stable ultra-small gold nanoparticles (Au-NPs) using Egyptian propolis extract, which showed potent antimicrobial, antimycobacterial, and anti-cancer cell proliferation effects. In vivo experiments revealed that low doses of Au-NPs were safe to use, while high doses accumulated in the liver, kidney, and brain tissues.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Article
Biochemistry & Molecular Biology
Aydan Dag, Eda Cakilkaya, Pinar Sinem Omurtag Ozgen, Sezen Atasoy, Gulsah Yigit Erdem, Busra Cetin, Aytac Cavus Kokuroglu, Ayse Gul Gurek
Summary: This study focused on the preparation of glycopolymeric nanoparticles containing a photosensitizer and an anticancer drug for combined cancer therapy. The nanoparticles demonstrated remarkable photophysical and photochemical properties, as well as targetability towards breast cancer cells. In vitro experiments showed superior chemo-photodynamic combination therapeutic efficacy compared to traditional treatments.
Article
Materials Science, Biomaterials
Sensen Zhou, Cheng Li, Yang Yuan, Lei Jiang, Weizhi Chen, Xiqun Jiang
Summary: This study reports a novel tumor-targeted liposome based on the protein-anchored cell membrane architecture. The liposome, called dtDLP, was constructed through the electrostatic interaction between dendritic lipopeptide liposomes and a dual-targeted recombinant protein, and it demonstrated superior tumor homing, cellular endocytotic, and penetration abilities.
BIOMATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Catherine E. Vasey, Robert J. Cavanagh, Vincenzo Taresco, Cara Moloney, Stuart Smith, Ruman Rahman, Cameron Alexander
Summary: Glioblastoma is the most common and aggressive brain tumor in adults, with limited survival despite multimodal treatments. PEGylated poly(lactide)-poly(carbonate)-doxorubicin nanoparticles showed tumor cell-killing effects, and the release of DOX from polymer-DOX conjugate nanoparticles in thermosensitive matrices was effective over clinically relevant time scales. Future in vivo assessments are needed to evaluate the potential of these nanoparticles in penetrating brain parenchyma.
Article
Biochemistry & Molecular Biology
Yang W. Shao, Geoffrey A. Wood, Jinchang Lu, Qing-Lian Tang, Jonathan Liu, Sam Molyneux, Yan Chen, Hui Fang, Hibret Adissu, Trevor McKee, Paul Waterhouse, Rama Khokha
Article
Agriculture, Multidisciplinary
Zhigao Wang, Rui Xue Zhang, Cheng Zhang, Caixia Dai, Xingrong Ju, Rong He
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Keumhan Noh, K. Sandy Pang
BIOPHARMACEUTICS & DRUG DISPOSITION
(2019)
Article
Multidisciplinary Sciences
Yaguang Li, Junhong Liu, Gaixia Liu, Zhenhong Pan, Mingxia Zhang, Yao Mao, Qingxia Wei, Hongping Xia, Rui Xue Zhang, Junjun She
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Agriculture, Multidisciplinary
Chong Chen, Cheng Zhang, Ruixue Zhang, Xingrong Ju, Rong He, Zhigao Wang
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2020)
Article
Pharmacology & Pharmacy
Mohammad Ali Amini, Taksim Ahmed, Fuh-Ching Franky Liu, Azhar Z. Abbasi, Chesarahmia Dojo Soeandy, Rui Xue Zhang, Preethy Prashad, Carolyn L. Cummins, Andrew M. Rauth, Jeffrey T. Henderson, Xiao Yu Wu
Summary: This study successfully developed a polymer-lipid hybrid nanoparticle (PLN) system with size and shape transformability and investigated its mechanisms of cellular uptake and intracellular trafficking. The findings suggest that the transformability of PLNs and lipid-biology interplay can enhance drug penetration and retention in tumor cells and intracellular targets.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Pharmacology & Pharmacy
Rui Xue Zhang, Ken Dong, Zhigao Wang, Ruimin Miao, Weijia Lu, Xiao Yu Wu
Summary: Drug dosing in clinical practice plays a critical role in determining patients' outcomes. Intestinal CYP3A4 metabolism must be addressed, and lipid-based oral drug delivery nanoparticles show promise in improving drug bioavailability and reducing pharmacokinetic variability.
Article
Engineering, Biomedical
Ruimin Miao, Fanqi Jin, Zhigao Wang, Weijia Lu, Junhong Liu, Xinyang Li, Rui Xue Zhang
Summary: This study developed upper intestinal absorptive polymer-lipid hybrid nanoparticles (PLN) to improve the oral bioavailability of polyphenols. The results showed that these nanoparticles enabled enhanced drug absorption and antioxidant effects in the intestine.
Article
Multidisciplinary Sciences
Weijia Lu, Ruimin Miao, Sijun Hu, Junhong Liu, Fanqi Jin, Rui Xue Zhang
Summary: This article provides a detailed guide on establishing and maintaining a permanent JVC rat model, focusing on the placement and sealing of the jugular cannula. It emphasizes the importance of monitoring physiological and hematological parameters, presenting results during a 6-day post-surgery recovery period. The drug-plasma concentration-time profile of orally administered natural phenol ellagic acid was also determined in the JVC rat model.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Review
Instruments & Instrumentation
Rui Xue Zhang, Franky Fuh-Ching Liu, Hoyin Lip, Junhong Liu, Qianrong Zhang, Xiao Yu Wu
Summary: Chronic oxidative stress and inflammation promote tumorigenesis and tumor progression, while certain chemotherapeutic drugs and radiation are applied to produce free radicals against cancer cells. Dietary antioxidants like omega-3 polyunsaturated fatty acids (PUFA) have been combined with cancer therapies to reduce tumor-promoting oxidative stress and protect normal tissue from chemotherapy and radiation-associated toxicity. However, the results of clinical studies are mixed and may even exacerbate adverse effects. Recent publications suggest that nano-formulations can enhance the therapeutic benefits of PUFA and other free-radical generating cytotoxic drugs during chemotherapy by controlling oxidative stress within a nanoscale vicinity. This article critically evaluates the concurrent use of dietary omega-3 PUFA as an adjuvant to cancer therapies, reviews the findings in studies using nanoparticle formulations, and highlights the importance of spatiotemporal manipulation of oxidative stress by pharmaceutical nanotechnology for improving outcomes with cancer therapies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chenshuang Li, Xi Chen, Siqi Zhang, Chen Liang, Ruixue Zhang, Hong Yan
Summary: Oxidative stress induces protein S-glutathionylation, which regulates the structure and function of target proteins and is involved in the pathogenesis of various diseases. The cytoplasmic deglutathionylating enzyme, Grx1, plays a crucial role in maintaining cellular redox state and preventing protein-thiol mixed disulfide accumulation. Our study demonstrates that the downregulation of Grx1 exacerbates oxidative stress, protein S-glutathionylation, and EMT in the context of cataract surgery. Additionally, we identify CK1 alpha as a target of S-glutathionylation, which further activates the Wnt/β-catenin signaling pathway and aggravates EMT.
Review
Pharmacology & Pharmacy
Xinyang Li, Chen Liang, Yexuan Guo, Jing Su, Xi Chen, Robert B. Macgregor Jr, Rui Xue Zhang, Hong Yan
Summary: Posterior capsule opacification (PCO) is the most common cause of vision loss after cataract surgery. Current clinical management strategies, such as implantation of specially designed intraocular lenses (IOL) or laser ablation, have limitations and associated complications. This review focuses on recent advances in drug delivery approaches, including drug-eluting IOLs, injectable hydrogels, nanoparticles, and implants, for PCO prophylaxis. Rational design of drug delivery systems considering the intraocular environment and long-term ocular safety shows potential for safe and effective anti-PCO therapies.
Article
Food Science & Technology
Zhigao Wang, Yao Chen, Nan Zhang, Rui Xue Zhang, Rong He, Xingrong Ju, Nilufar Z. Mamadalieva
Summary: Janus particles with anisotropic surfaces, prepared by decorating latex particles with plant protein-based nanogels, show potential for preserving perishable food.
Article
Pharmacology & Pharmacy
Jing Su, Weijia Lu, Yexuan Guo, Zhuoyi Liu, Xu Wang, Hong Yan, Rui Xue Zhang
Summary: Periocular routes have great potential for the treatment of chronic eye diseases by exploiting the scleral structure. In this study, phosphatidylcholine-based liposomes (LIP-DM) were developed to deliver water-soluble steroid dexamethasone and antibiotics moxifloxacin through the sclera. The results demonstrated that LIP-DM exhibited differential release of the two drugs, with fast release of moxifloxacin and slow release of dexamethasone, leading to increased transscleral contact time and enhanced antibacterial and anti-inflammatory effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xinyang Li, Yexuan Guo, Robert B. Macgregor Jr, Hong Yan, Rui Xue Zhang
Summary: Multidrug nanomedicine is an effective approach for treating chronic diseases and cancers. However, achieving co-encapsulation and release of drug combinations at a fixed ratio by nanoparticles, especially for long acting ocular formulations, is challenging. In this study, poly (lactic-co-glycolic acid) nanoparticles were developed using microfluidics and the Design of Experiments approaches to ratiometrically co-encapsulate mitomycin C and doxorubicin. The drug release rate was found to be a critical determinant of efficacy, with slower release leading to lower effectiveness against pathogenic processes. These findings highlight the potential of microfluidics for synthesizing polymeric nanoparticles and emphasize the importance of drug release rate in long-acting nanomedicine design.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)