Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase

(2018) Tomoki Sugiyama et al.   BRAIN RESEARCH

Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage

(2018) Qian-Qian Li et al.   Frontiers in Neurology

Programmed Cell Death after Intracerebral Hemorrhage

(2018) Tobias Bobinger et al.   Current Neuropharmacology

Intracerebral haemorrhage: current approaches to acute management

(2018) Charlotte Cordonnier et al.   LANCET

The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase injury

(2017) Takahiko Imai et al.   NEUROREPORT

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells

(2017) Tasuku Hirayama et al.   Chemical Science

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

(2017) Chun-Chun Wei et al.   Scientific Reports

Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage

(2017) Hyunjung Min et al.   Molecular Brain

Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage

(2017) Yanjiang Li et al.   PLoS One

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier

(2016) Toshinori Takagi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage

(2016) Jenna L Leclerc et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice

(2016) Zhen Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

(2016) Bo Ma et al.   Journal of Neuroinflammation

Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation

(2016) Takahiko Imai et al.   NEUROBIOLOGY OF DISEASE

The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria

(2016) Jie Qu et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets

(2016) Xin Hu et al.   Oxidative Medicine and Cellular Longevity

Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

(2016) Li-Fang Wang et al.   Scientific Reports

Brain iron overload following intracranial haemorrhage

(2016) Thomas Garton et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

(2015) Nils Schallner et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier

(2015) Ryan C. McCarthy et al.   Frontiers in Molecular Neuroscience

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy

(2014) Ryan C. McCarthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of Pericytes in Neurovascular Unit Remodeling in Brain Disorders

(2014) Ayman ElAli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Red Blood Cell Lysis and Iron in Hydrocephalus after Intraventricular Hemorrhage

(2014) Chao Gao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

High Dose Deferoxamine in Intracerebral Hemorrhage (Hi-Def) Trial: Rationale, Design, and Methods

(2013) Sharon D. Yeatts et al.   Neurocritical Care

Hematology and Inflammatory Signaling of Intracerebral Hemorrhage

(2013) W. C. Ziai   STROKE

Bipyridine, an Iron Chelator, Does Not Lessen Intracerebral Iron-Induced Damage or Improve Outcome After Intracerebral Hemorrhagic Stroke in Rats

(2013) Jayalakshmi Caliaperumal et al.   Translational Stroke Research

Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy

(2012) Ashlee N. Higdon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

International Epidemiology of Intracerebral Hemorrhage

(2012) M. Arfan Ikram et al.   Current Atherosclerosis Reports

Efficacy of the lipid-soluble iron chelator 2,2′-dipyridyl against hemorrhagic brain injury

(2011) He Wu et al.   NEUROBIOLOGY OF DISEASE

Safety and Tolerability of Deferoxamine Mesylate in Patients With Acute Intracerebral Hemorrhage

(2011) Magdy Selim et al.   STROKE

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

Hemoglobin-Induced Oxidative Stress Contributes to Matrix Metalloproteinase Activation and Blood–Brain Barrier Dysfunction in vivo

(2010) Masataka Katsu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway

(2009) Jing Chen-Roetling et al.   NEUROPHARMACOLOGY