Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

Health benefits of resveratrol: Evidence from clinical studies

(2019) Akhand Pratap Singh et al.   MEDICINAL RESEARCH REVIEWS

Genetics of polycystic liver diseases

(2019) Pui Y. Lee-Law et al.   CURRENT OPINION IN GASTROENTEROLOGY

Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells

(2018) Yuwan Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

The global burden of kidney disease and the sustainable development goals

(2018) Valerie A Luyckx et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Trans -resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys

(2018) Heba Al-Hussaini et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resveratrol provides benefits in mice with type II diabetes‑induced chronic renal failure through AMPK signaling pathway

(2018) Haiyan Guo et al.   Experimental and Therapeutic Medicine

Metabolically healthy obesity: the low-hanging fruit in obesity treatment?

(2018) Norbert Stefan et al.   Lancet Diabetes & Endocrinology

Malnutrition in Chronic Kidney Disease

(2018) Franca M. Iorember   Frontiers in Pediatrics

Epidemiology of Renal Cell Carcinoma

(2018) Umberto Capitanio et al.   EUROPEAN UROLOGY

Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress

(2018) Tao Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resveratrol exerts dose-dependent anti-fibrotic or pro-fibrotic effects in kidneys: a potential risk to individuals with impaired kidney function

(2018) Shuyun Liu et al.   PHYTOMEDICINE

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

(2018) Alexa Serino et al.   Nutrients

Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress

(2017) He Peiyuan et al.   Evidence-based Complementary and Alternative Medicine

Vitamin D and osteoporosis in chronic kidney disease

(2017) Paul Lips et al.   JOURNAL OF NEPHROLOGY

Progression of chronic kidney disease: too much cellular talk causes damage

(2017) Leslie Gewin et al.   KIDNEY INTERNATIONAL

Resveratrol ameliorates diabetic nephropathy in rats through negative regulation of the p38 MAPK/TGF-β1 pathway

(2017) Yuan Qiao et al.   Experimental and Therapeutic Medicine

The Players: Cells Involved in Glomerular Disease

(2016) A. R. Kitching et al.   Clinical Journal of the American Society of Nephrology

Protection of resveratrol on acute kidney injury in septic rats

(2016) Y Gan et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Glomerular filtration rate equations: a comprehensive review

(2016) Carlos G. Musso et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway

(2016) Ting He et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effects of Resveratrol Supplementation in Nrf2 and NF-κB Expressions in Nondialyzed Chronic Kidney Disease Patients: A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial

(2016) Juliana F. Saldanha et al.   JOURNAL OF RENAL NUTRITION

HRD1-Mediated IGF-1R Ubiquitination Contributes to Renal Protection of Resveratrol indb/dbMice

(2016) Caifeng Yan et al.   MOLECULAR ENDOCRINOLOGY

Resveratrol delays polycystic kidney disease progression through attenuation of nuclear factor κB-induced inflammation

(2016) Ming Wu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

(2016) Siqi Xu et al.   Oxidative Medicine and Cellular Longevity

Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat

(2016) Liqun Ma et al.   PATHOLOGY RESEARCH AND PRACTICE

Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study

(2016) Chong-Ting Lin et al.   RENAL FAILURE

Measuring and Assessing Kidney Function

(2016) Priya Vart et al.   SEMINARS IN NEPHROLOGY

Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma

(2016) Chulwon Kim et al.   BMC Nephrology

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

(2016) Jessy Moore et al.   Nutrients

Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis

(2015) A. R. Vieira et al.   ANNALS OF ONCOLOGY

The pharmacology of resveratrol in animals and humans

(2015) Eun-Jung Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol attenuates renal injury and fibrosis by inhibiting transforming growth factor-β pathway on matrix metalloproteinase 7

(2015) Zhou Xiao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Resveratrol upregulates Egr-1 expression and activity involving extracellular signal-regulated protein kinase and ternary complex factors

(2015) Oliver G. Rössler et al.   EXPERIMENTAL CELL RESEARCH

Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro

(2015) YEN TA HUANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The cell biology of renal filtration

(2015) Rizaldy P. Scott et al.   JOURNAL OF CELL BIOLOGY

The Phytoalexin Resveratrol Ameliorates Ochratoxin A Toxicity in Human Embryonic Kidney (HEK293) Cells

(2015) Shanel Raghubeer et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol prevents high glucose-induced epithelial–mesenchymal transition in renal tubular epithelial cells by inhibiting NADPH oxidase/ROS/ERK pathway

(2015) Ting He et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways

(2015) Ying Wang et al.   TOXICOLOGY LETTERS

Cellular and Molecular Mechanisms of Chronic Kidney Disease with Diabetes Mellitus and Cardiovascular Diseases as Its Comorbidities

(2015) Prathibha Reddy Gajjala et al.   Frontiers in Immunology

Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway

(2014) Yongheng Bai et al.   BIOCHEMICAL PHARMACOLOGY

The Glomerulus: The Sphere of Influence

(2014) M. R. Pollak et al.   Clinical Journal of the American Society of Nephrology

Distal Convoluted Tubule

(2014) A. R. Subramanya et al.   Clinical Journal of the American Society of Nephrology

Ochratoxin A and Human Health Risk: A Review of the Evidence

(2014) Travis R. Bui-Klimke et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Resveratrol and cancer: focus on in vivo evidence

(2014) Lindsay G Carter et al.   ENDOCRINE-RELATED CANCER

Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats

(2014) H Elbe et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

The kidney - an organ of critical importance in physiology

(2014) Louise Robson   JOURNAL OF PHYSIOLOGY-LONDON

The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy

(2014) Hongfei Ji et al.   MOLECULAR BIOLOGY REPORTS

Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration

(2014) C. Zoja et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats

(2014) Weiqian Zhang et al.   Nutrition Research and Practice

Anti-nephrolithic potential of resveratrol via inhibition of ROS, MCP-1, hyaluronan and osteopontin in vitro and in vivo

(2014) Sang Hyuk Hong et al.   Pharmacological Reports

Resveratrol Prevention of Diabetic Nephropathy Is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of Akt/NF-κB Pathway

(2014) Feng Xu et al.   International Journal of Endocrinology

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

(2014) Yao-Cheng Lin et al.   Nature Communications

Prevalence estimates of chronic kidney disease in Canada: results of a nationally representative survey

(2013) P. Arora et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial

(2013) S. Bo et al.   CURRENT MEDICINAL CHEMISTRY

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

(2013) Albino Carrizzo et al.   FOOD AND CHEMICAL TOXICOLOGY

Resveratrol Attenuates Early Diabetic Nephropathy by Down-Regulating Glutathione S-Transferases Mu in Diabetic Rats

(2013) Bei Jiang et al.   JOURNAL OF MEDICINAL FOOD

Resveratrol: Why Is It a Promising Therapy for Chronic Kidney Disease Patients?

(2013) Juliana F. Saldanha et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Inhibits the Epithelial Sodium Channel via Phopshoinositides and AMP-Activated Protein Kinase in Kidney Collecting Duct Cells

(2013) Kelly M. Weixel et al.   PLoS One

Resveratrol as a therapeutic agent for renal fibrosis induced by unilateral ureteral obstruction

(2013) Jin Liang et al.   RENAL FAILURE

Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension

(2012) Peter Hansell et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol

(2012) Lanyu Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

Bioavailability of resveratrol

(2011) Thomas Walle   Annals of the New York Academy of Sciences

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Kidney: Its impact on glucose homeostasis and hormonal regulation

(2011) Asimina Mitrakou   DIABETES RESEARCH AND CLINICAL PRACTICE

Treatment of chronic kidney disease

(2011) Jeffrey M. Turner et al.   KIDNEY INTERNATIONAL

Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal cancer cells

(2011) Huizhen Zhang   Molecular Medicine Reports

Metabolites and tissue distribution of resveratrol in the pig

(2011) María Azorín-Ortuño et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells

(2011) Ying Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Resveratrol ameliorates high glucose-induced protein synthesis in glomerular epithelial cells

(2009) Myung-Ja Lee et al.   CELLULAR SIGNALLING

Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC

(2009) M. Emília Juan et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

(2009) Luis Almeida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol bioavailability and toxicity in humans

(2009) Charles-Henry Cottart et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Guidelines for the management of chronic kidney disease

(2008) A. Levin et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B

(2008) Balachandar Venkatesan et al.   FASEB JOURNAL

Quantification of free and protein-boundtrans-resveratrol metabolites and identification oftrans-resveratrol-C/O-conjugated diglucuronides – Two novel resveratrol metabolites in human plasma

(2008) Alexander Burkon et al.   MOLECULAR NUTRITION & FOOD RESEARCH