Article
Biochemistry & Molecular Biology
Michael Gekle, Sigrid Mildenberger
Summary: Mineralocorticoid aldosterone induces cytosolic alkalization in rat glomerular mesangial cells through NHE and ERK1/2 activation, promoting cell proliferation and collagen secretion.
Article
Pharmacology & Pharmacy
Sergejs Zavadskis, Adelheid Weidinger, Dominik Hanetseder, Asmita Banerjee, Cornelia Schneider, Susanne Wolbank, Darja Marolt Presen, Andrey Kozlov
Summary: The study found that the inhibitor DPI has different effects on ROS metabolism and mitochondrial function in various types of cells, such as stem cells and differentiated cells, depending on the cell's energy metabolism. Undifferentiated cells may be a better target for DPI compared to differentiated parenchymal cells.
Article
Biochemistry & Molecular Biology
Javier Marques, Joaquin Fernandez-Irigoyen, Elena Ainzua, Maria Martinez-Azcona, Adriana Cortes, Carmen Roncal, Josune Orbe, Enrique Santamaria, Guillermo Zalba
Summary: NADPH oxidases (NOX) are the main source of reactive oxygen species (ROS) in blood vessels. NOX5, the latest member of the NOX family, plays a role in endothelial dysfunction and the onset of cardiovascular diseases. Overexpression of NOX5 inhibits cell proliferation, promotes apoptosis, alters metabolism, and increases cell migration in endothelial cells.
Article
Cell Biology
Sarika Chaudhari, Parisa Yazdizadeh Shotorbani, Yu Tao, Ramesh Kasetti, Gulab Zode, Keisa W. Mathis, Rong Ma
Summary: This study demonstrates the expression of neogenin receptor in glomerular mesangial cells and its role in regulating ECM protein production. High glucose and oxidative stress can increase neogenin expression, while antioxidant treatment can attenuate this increase. The previously unrecognized neogenin-fibronectin pathway may contribute to glomerular injury responses during the course of diabetic nephropathy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying-Ying Chen, Tsung-Tien Wu, Chiu-Yi Ho, Tung-Chen Yeh, Gwo-Ching Sun, Ching-Jiunn Tseng, Pei-Wen Cheng
Summary: Chronic hyperglycemia leads to oxidative stress in patients with diabetes, causing damage to their vision. This study found that dapagliflozin, metformin, and resveratrol can reduce oxidative stress. These findings suggest that blocking SGLT2 may be beneficial for improving cataracts in patients with diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guo Lixia, Zhao Haiyun, Zheng Xia
Summary: The study found that resveratrol could reduce blood pressure, cholesterol, triglyceride, and low-density lipoprotein levels in patients with atherosclerosis, as well as decrease the expression of NADPH oxidase complex subunits gp91Phox and P22Phox in vascular smooth muscle cells. Resveratrol shows potential as an effective medicine for treating atherosclerosis, but further studies are necessary to confirm its efficacy.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ke Jin, Zhenke Wen, Bowen Wu, Hui Zhang, Jingtao Qiu, Yanan Wang, Kenneth J. Warrington, Gerald J. Berry, Jorg J. Goronzy, Cornelia M. Weyand
Summary: The dysfunction of CD8(+) regulatory T cells in autoimmune vasculitis is attributed to aberrant NOTCH4 signaling, leading to limited vesicular secretion of the enzyme NADPH oxidase 2 (NOX2) and subsequent breakdown of tissue tolerance, resulting in aggressive vessel wall inflammation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Hassan Dakik, Maya El Dor, Joan Leclerc, Farah Kouzi, Ali Nehme, Margaux Deynoux, Christelle Debeissat, Georges Khamis, Elfi Ducrocq, Aida Ibrik, Marie-Jose Stasia, Houssam Raad, Hamid Reza Rezvani, Fabrice Gouilleux, Kazem Zibara, Olivier Herault, Frederic Mazurier
Summary: The study found that NOX2 is widely expressed in AML blasts, especially in certain types of cells, but less expressed in stem cells and relapsed AML. Endogenous NOX activity could not be detected without stimulation. Although CYBB knockdown affected NOX2 activity, it did not impact the proliferation and differentiation of THP-1 and HL-60 cells.
Article
Biochemistry & Molecular Biology
Yosef Fichman, Sara Zandalinas, Scott Peck, Sheng Luan, Ron Mittler
Summary: The leucine-rich-repeat receptor-like kinase HPCA1 plays a key role in mediating and coordinating systemic cell-to-cell reactive oxygen species and calcium signals required for plant acclimation to stress.
Article
Biochemistry & Molecular Biology
Eun-Ju Lee, Khurshid Ahmad, Shiva Pathak, SunJu Lee, Mohammad Hassan Baig, Jee-Heon Jeong, Kyung-Oh Doh, Dong-Mok Lee, Inho Choi
Summary: This study introduces novel peptides derived from fibronectin that enhance cell adhesion, proliferation, and differentiation, offering a new approach to cell culture. The peptides showed significant effects on primary cells and stem cells, increasing proliferation and promoting differentiation into specific cell types such as osteoblasts. The results suggest potential applications in the production of core materials for cell culture such as scaffolds and culture medium components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Xia Tan, Yexin Liu, Di Liu, Xiaofang Tang, Ming Xia, Guochun Chen, Liyu He, Xuejing Zhu, Hong Liu
Summary: This study reveals that the expression of protein SUMO1 is upregulated in IgA nephropathy and is associated with inhibition of autophagy. In a stimulated mesangial cell model, inhibiting SUMOylation or silencing SUMO1 can promote autophagy and decrease cell proliferation.
FRONTIERS IN MEDICINE
(2022)
Article
Physiology
Ning Xia, Stefan Tenzer, Oleg Lunov, Martin Karl, Thomas Simmet, Andreas Daiber, Thomas Muenzel, Gisela Reifenberg, Ulrich Foerstermann, Huige Li
Summary: The study showed that both SIRT1 and non-sirtuin deacetylases play a role in regulating NADPH oxidase activity, with Rac1 being directly deacetylated by SIRT1 in a cell-free system to inhibit its interaction with p67phox. The downstream targets of non-sirtuin deacetylases remain unknown, and further investigation is needed to understand the in vivo significance of these findings.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yao Li, Damir Kracun, Christopher M. Dustin, Mohamed El Massry, Shuai Yuan, Christian J. Goossen, Evan R. DeVallance, Sanghamitra Sahoo, Cynthia St Hilaire, Aditi U. Gurkar, Toren Finkel, Adam C. Straub, Eugenia Cifuentes-Pagano, Patrick J. Pagano
Summary: In an investigation into signaling triggered by aging and hyperglycemia, researchers found that NADPH Oxidase (NOX) plays a crucial role in driving cell damage, inflammation, and cellular senescence. Inhibiting NOX1 can reverse age-related impairments in blood flow and angiogenesis, as well as disrupt proinflammatory signaling associated with senescence. Targeting the NOX1-SASP signaling axis is predicted to be an effective strategy for mitigating vascular and organ system senescence.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Jiulong Li, Xiang Wang, Kuo-Ching Mei, Chong Hyun Chang, Jinhong Jiang, Xiangsheng Liu, Qi Liu, Linda M. Guiney, Mark C. Hersam, Yu-Pei Liao, Huan Meng, Tian Xia
Summary: Graphene oxide (GO) as a two-dimensional nanomaterial shows high potential in biomedical applications, with its toxicity in liver cells mainly dependent on lateral size, inducing strong effects in Kupffer cells while showing lower toxicity in liver sinusoidal endothelial cells and hepatocytes.
Article
Biotechnology & Applied Microbiology
Yu Shang, Yu-Ling Jiang, Li-Jun Ye, Li-Na Chen, Yue Ke
Summary: The study demonstrated that overexpression of MAGEA12 enhances cell viability and colony formation in OSCC cells by activating the Akt signaling pathway. Resveratrol treatment inhibits cell proliferation and colony formation in Cal-27 cells by downregulating MAGEA12 and p-Akt levels. These findings suggest that resveratrol may be a potential therapeutic drug for OSCC treatment.
Article
Multidisciplinary Sciences
Ke Wu, Hongxia Zhong, Quanbing Guo, Jibo Tang, Jing Zhang, Lihua Qian, Zhifeng Shi, Chendong Zhang, Shengjun Yuan, Shunping Zhang, Hongxing Xu
Summary: Stacking atomically thin films allows for the construction of van der Waals heterostructures with exotic functionalities. Here, we investigate the optical transitions in WS2/WSe2 heterobilayers and attribute a specific transition to an indirect Gamma-K transition. Our findings provide new insights into the properties of twist-angle-dependent excitons.
NATIONAL SCIENCE REVIEW
(2022)
Article
Electrochemistry
Benjamin Mulwa Kathale, Hengbo Xiao, Shengxiong Yang, Hongxia Yin, Tianshui Yu, Xiangji Zhou, Lihua Qian, Junwu Xiao, Pengxiang Lei, Xiuhong Li
Summary: By modulating the structure of NiFe catalysts using different concentrations of F, this study achieves a hybrid structure with good conductivity and collaborative operation between Ni and Fe, leading to improved oxygen evolution reaction (OER) performance.
ELECTROCHIMICA ACTA
(2022)
Article
Materials Science, Multidisciplinary
Ke Wu, Hongxia Zhong, Quanbing Guo, Jibo Tang, Zhenyu Yang, Lihua Qian, Shengjun Yuan, Shunping Zhang, Hongxing Xu
Summary: This study reveals the correlation between the patterned photoluminescence (PL) emission and the details of defects in chemical vapor deposition (CVD)-grown hexagonal WS2 monolayer through optical and structural characterizations and ab initio calculations. The temperature-dependent PL spectra show the correlation between defect-trapped and band-edge exciton emission. High-resolution scanning transmission electron microscopy identifies the positive correlation between WSx-vacancy density and PL intensity. Ab initio calculations and molecule adsorption PL spectra show that the coexistence of p- and n-doping effects weakens the modulation of molecular adsorption on PL intensity.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Plant Sciences
Erkui Yue, Yuqing Huang, Lihua Qian, Qiujun Lu, Xianbo Wang, Haifeng Qian, Jianli Yan, Songlin Ruan
Summary: Tetrastigma hemsleyanum is a rare and wild medicinal resource, with proanthocyanidins accumulating in large amounts in its purple leaves and involving several key genes in the metabolic pathway, indicating a complex regulatory network that may differ from other species.
Article
Business, Finance
Lihua Qian, Jiqian Wang, Feng Ma, Ziyang Li
Summary: This study mainly focuses on the role of jumps in forecasting Bitcoin volatility using linear and nonlinear mixed data sampling models. The results provide strong evidence that using a forecasting model that incorporates continuous-time jump and two-stage regimes can significantly improve predictive accuracy and achieve high economic gains, particularly during highly volatile periods such as Black Swan events.
FINANCE RESEARCH LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Weimin Yang, Miao-Miao Liang, Guo-Ya Sun, Jingyu Wang, Yonglin He, Lihua Qian, Jing-Liang Yang, Pei-Wen Ren, Min Gao, Zhong-Qun Tian, Jian-Feng Li, Zhilin Yang
Summary: This study constructs a three-dimensional multi-hot spot model using the Monte Carlo algorithm to investigate the influence of multiple random factors on the fluctuations of electric field intensity. It is found that the fluctuations can be effectively suppressed when the hot spot density exceeds a certain threshold value. These theoretical results are confirmed by preliminary surface-enhanced Raman scattering experiments. This study is of great significance for understanding the interplay between disorder and local electric field fluctuations in surface plasmon resonance complex systems and provides a new method for precise quantitative analysis in plasmon-enhanced spectroscopy techniques.
Article
Business, Finance
Lihua Qian, Qing Zeng, Xinjie Lu, Feng Ma
Summary: This paper investigates the value of global tail risk for oil return prediction and finds that the World Fear index performs well in predicting oil returns, especially during recessions, providing new insights for the oil market.
FINANCE RESEARCH LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Xiang Wu, Jiaxuan Zhang, Richu Wang, Zainab Zafar, Xiaochun Liu, Yujing Liu, Lihua Qian, Lixin Sun
Summary: This study reports the introduction of hierarchical precipitations and microstructural heterogeneities to overcome the tradeoff between strength and conductivity in Cu-Ag-Zr alloy. The introduced heterogeneous precipitate configurations alter the evolution of deformation structures during cold rolling and aging, resulting in an excellent combination of tensile strength, electrical conductivity, and tensile elongation. The findings propose a novel approach for designing high-strength, high-conductivity, and high-thermal stability copper alloys.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Tianshui Yu, Xiangji Zhou, Yu Chen, Jin Chen, Songliu Yuan, Lihua Qian, Xianglong Lu, Pan Liu, Pengxiang Lei, Xiuhong Li
Summary: This study evaluates the behavior of mass transport within nanoscale channels using nanoporous gold (NPG) and identifies its contribution to catalytic activity. The results show a positive correlation between pore size and specific current density of CO production, and suggest a critical size of 46 nm for designing hierarchical porous catalysts with high electrochemical activity in the future.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Hengbo Xiao, Kai Chi, Hongxia Yin, Xiangji Zhou, Pengxiang Lei, Peizhi Liu, Jiakun Fang, Xiuhong Li, Songliu Yuan, Zhen Zhang, Yaqiong Su, Junjie Guo, Lihua Qian
Summary: Oxygen vacancies in transition metal oxides can be used to modulate surface reconstruction for enhancing the oxygen evolution reaction (OER). In this study, oxygen vacancies were specifically localized within MoO4 tetrahedrons rather than CoO6 octahedrons in the CoMoO4 catalyst, resulting in the coherent reconstruction of CoO6 octahedrons into pure CoOOH with tunable OER activities. The manipulated distorted polyhedrons facilitated the complete transformation of CoO6 octahedrons into pure CoOOH at lower potentials, leading to a significantly improved intrinsic activity for OER.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiangji Zhou, Lihua Qian, Tianshui Yu, Hengbo Xiao, Lin Liu, Yao Yu, Pengxiang Lei
Summary: In this study, it is found that the volume diffusion of Bi atoms in nanoporous AgBi can be driven by electrochemical potential at room temperature, leading to the conformal covering of an amorphous Bi2O3 shell. The growth kinetics of the amorphous shell show that the potential dependence of Bi volume diffusion activation energy is 0.932 eV V-1. Compared with temperature dependence, potential supply is more feasible to modulate volume diffusion rate and shell thickness.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Electrochemistry
Tianshui Yu, Xiangji Zhou, Yu Chen, Jin Chen, Songliu Yuan, Zhen Zhang, Lihua Qian, Song Li
Summary: A hierarchically nanoporous gold (H-NPG) with high CO conversion of 96% was configured, which is mainly determined by the high fraction of active sites onto the nanoscale skeletons and the high volume of hierarchically nanoporous channels. In addition, the H-NPG exhibits robust durability with only a 22% reduction of CO specific current density after 22 hours of CO2ER, compared to a 55% reduction in nanoporous gold (NPG) with nanoporous channels. This durability is attributed to the conversion of some crystalline facets with low activity to (110) facets with high activity during CO2ER.
ELECTROCHIMICA ACTA
(2023)
Article
Engineering, Biomedical
Guangliang Zhang, Zhiqiang Zhang, Gaobiao Cao, Qianheng Jin, Lei Xu, Jiaying Li, Zhe Liu, Chi Xu, Yingying Le, Yi Fu, Jihui Ju, Bin Li, Ruixing Hou
Summary: This study explored the application of GelMA-HAMA-fibrin scaffold in 3D bioprinting, which can promote vascularisation and wound healing under confined force loading, providing new treatment methods for tissue engineering.
ACTA BIOMATERIALIA
(2023)
Article
Green & Sustainable Science & Technology
Bo Shi, Dandan Zhu, Pengxiang Lei, Ximin Li, Hengbo Xiao, Lihua Qian
Summary: In this study, hazardous chemicals in industrial effluent, including phosphorate, silicate, and arsenate, are selectively precipitated onto inorganic flocculants, while the vanadate dissolved in an aqueous solution remains undisturbed. High purity NH4VO3 is produced by crystallization from the purified solution. Polyaluminum sulfate with an optimal amount of 50 g/L is demonstrated to selectively remove phosphorate, silicate, and arsenate with removing efficiencies of 93.39%, 97.11%, and 88.31%, respectively. The purity of NH4VO3 from the purified solution reaches 99.21%, compared to 98.33% in the product from the crude solution. This purification technology not only produces NH4VO3 with high added value but also reduces environmental pollution.
JOURNAL OF RENEWABLE MATERIALS
(2023)
Article
Horticulture
Qiaojuan Fu, Xiaoying Zhang, Fukang Zhao, Ruoxin Ruan, Lihua Qian, Chunnan Li
Summary: In this study, a classification model GL-CNN based on a convolutional neural network is proposed to solve the problem of Cymbidium classification. By expanding the image set and using a cascade fusion strategy, it achieves the highest classification prediction accuracy.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)