Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1

Melatonin inhibits epithelial‑to‑mesenchymal transition in gastric cancer cells via attenuation of IL‑1β/NF‑κB/MMP2/MMP9 signaling

(2018) Xiaoting Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Current Challenges and Opportunities in Treating Glioblastoma

(2018) Andrea Shergalis et al.   PHARMACOLOGICAL REVIEWS

Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers

(2018) Cheng-Fang Tsai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

(2017) Robert S McNeill et al.   NEURO-ONCOLOGY

CCL2/CCR2 signaling pathway in glioblastoma multiforme

(2017) Alireza Vakilian et al.   NEUROCHEMISTRY INTERNATIONAL

MiR-181b modulates EGFR-dependent VCAM-1 expression and monocyte adhesion in glioblastoma

(2017) Y-S Liu et al.   ONCOGENE

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

(2016) Peng Yuan et al.   CANCER RESEARCH

Melatonin Stimulates the SIRT1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (LPS)-Induced Oxidative Stress to Rescue Postnatal Rat Brain

(2016) Shahid Ali Shah et al.   CNS Neuroscience & Therapeutics

Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway

(2016) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

(2016) Sokrates Stein et al.   Aging-US

Melatonin: an inhibitor of breast cancer

(2015) S. M. Hill et al.   ENDOCRINE-RELATED CANCER

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

(2015) Xi Chen et al.   IMMUNOLOGY

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation

(2015) JUN FENG et al.   ONCOLOGY REPORTS

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

(2015) Xi Feng et al.   Oncotarget

Invasive Glioblastoma Cells Acquire Stemness and Increased Akt Activation

(2015) Jennifer R. Molina et al.   NEOPLASIA

Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways

(2013) Hsiao-Yun Lin et al.   NEUROBIOLOGY OF AGING

Melatonin treatment increases the transcription of cell proliferation-related genes prior to inducing cell death in C6 glioma cells in vitro

(2013) JIAGUI QU et al.   Oncology Letters

p38γ overexpression in gliomas and its role in proliferation and apoptosis

(2013) Kui Yang et al.   Scientific Reports

Sirtuin activators and inhibitors

(2012) José M. Villalba et al.   BIOFACTORS

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

(2012) A. M. Gil-Bernabe et al.   BLOOD

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

CCL2/CCR2 Chemokine Signaling Coordinates Survival and Motility of Breast Cancer Cells through Smad3 Protein- and p42/44 Mitogen-activated Protein Kinase (MAPK)-dependent Mechanisms

(2012) Wei Bin Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells

(2012) Juntao Wang et al.   JOURNAL OF PINEAL RESEARCH

The CCL2/CCR2 Axis Enhances Vascular Cell Adhesion Molecule-1 Expression in Human Synovial Fibroblasts

(2012) Yu-Min Lin et al.   PLoS One

MicroRNA-34a Suppresses Cell Proliferation and Induces Apoptosis in U87 Glioma Stem Cells

(2012) Lihua Sun et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Tumor Microenvironment in the Brain

(2012) Mihaela Lorger   Cancers

Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells

(2011) Dharminder Chauhan et al.   BRITISH JOURNAL OF HAEMATOLOGY

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Ghrelin induces cell migration through GHS-R, CaMKII, AMPK, and NF-κB signaling pathway in glioma cells

(2011) Jia-Hong Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin

(2011) Virginia Motilva et al.   JOURNAL OF PINEAL RESEARCH

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

(2011) Jörg H. Stehle et al.   JOURNAL OF PINEAL RESEARCH

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Regulatory T cells in tumor immunity

(2010) Hiroyoshi Nishikawa et al.   INTERNATIONAL JOURNAL OF CANCER

Integrin-linked kinase is involved in TNF-α-induced inducible nitric-oxide synthase expression in myoblasts

(2010) Hsi-Kai Tsou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

(2010) Camilla Krakstad et al.   Molecular Cancer

Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting

(2010) Zhi Huang et al.   Protein & Cell

N-Tosyl-l-phenylalanine Chloromethyl Ketone Inhibits NF-κB Activation by Blocking Specific Cysteine Residues of IκB Kinase β and p65/RelA

(2009) Kyung-Ho Ha et al.   BIOCHEMISTRY

Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials

(2009) A. Bishayee   Cancer Prevention Research

Involvement of NF- B and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein

(2009) S.-H. Kim et al.   CARCINOGENESIS

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin reduces cardiac inflammatory injury induced by acute exercise

(2009) C. Veneroso et al.   JOURNAL OF PINEAL RESEARCH

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis

(2009) Javier Mestas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes

(2008) Yoshiko Kawai et al.   CANCER SCIENCE

Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms

(2008) Venkataramanujan Srinivasan et al.   INTEGRATIVE CANCER THERAPIES