Tumor Microenvironment in the Brain

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

Astrocytic Regulation of Human Monocytic/Microglial Activation

(2014) A. M. Kostianovsky et al.   JOURNAL OF IMMUNOLOGY

Collagen VI Ablation Retards Brain Tumor Progression Due to Deficits in Assembly of the Vascular Basal Lamina

(2011) Weon-Kyoo You et al.   AMERICAN JOURNAL OF PATHOLOGY

Towards a new “stromal-based” classification system for human breast cancer prognosis and therapy

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Myeloid derived suppressor cells in human diseases

(2011) Tim F. Greten et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Glioblastoma-dependent differentiation and angiogenic potential of human mesenchymal stem cells in vitro

(2011) Tobias Birnbaum et al.   JOURNAL OF NEURO-ONCOLOGY

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis

(2010) Mihaela Lorger et al.   AMERICAN JOURNAL OF PATHOLOGY

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis

(2010) Toshihiro Seike et al.   CLINICAL & EXPERIMENTAL METASTASIS

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse

(2010) Feng-Ju Huang et al.   DEVELOPMENTAL BIOLOGY

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemato-vascular origins of endothelial progenitor cells?

(2010) Hsu Chao et al.   MICROVASCULAR RESEARCH

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Mesenchymal Stem Cells Modified with a Single-Chain Antibody against EGFRvIII Successfully Inhibit the Growth of Human Xenograft Malignant Glioma

(2010) Irina V. Balyasnikova et al.   PLoS One

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Genetically Modified CD34+ Hematopoietic Stem Cells Contribute to Turnover of Brain Perivascular Macrophages in Long-Term Repopulated Primates

(2009) Caroline Soulas et al.   AMERICAN JOURNAL OF PATHOLOGY

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

(2009) F. Pucci et al.   BLOOD

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Transforming Growth Factor- 2 Is a Molecular Determinant for Site-Specific Melanoma Metastasis in the Brain

(2009) C. Zhang et al.   CANCER RESEARCH

Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model

(2009) Juan JuanYin et al.   CLINICAL & EXPERIMENTAL METASTASIS

Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis

(2009) Frank Winkler et al.   GLIA

Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis

(2009) Langley   INTERNATIONAL JOURNAL OF ONCOLOGY

The role of microglia in central nervous system immunity and glioma immunology

(2009) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Management of brain metastases: the indispensable role of surgery

(2009) George Al-Shamy et al.   JOURNAL OF NEURO-ONCOLOGY

Circulating endothelial progenitor cells in malignant gliomas

(2009) Neysan Rafat et al.   JOURNAL OF NEUROSURGERY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

The Vascular Basement Membrane as “Soil” in Brain Metastasis

(2009) W. Shawn Carbonell et al.   PLoS One

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of tumor cell integrin  v 3 controls angiogenesis and metastatic growth in the brain

(2009) M. Lorger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

(2008) Michele De Palma et al.   CANCER CELL

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

(2008) Daniel P. Fitzgerald et al.   CLINICAL & EXPERIMENTAL METASTASIS

Ly6c+“inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

(2008) Daniel R. Getts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics

(2008) Naoki Umemura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival

(2008) Ashwatha Narayana et al.   JOURNAL OF NEUROSURGERY

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas

(2008) Y Komohara et al.   JOURNAL OF PATHOLOGY

Bone Marrow Multipotent Mesenchymal Stroma Cells Act as Pericyte-like Migratory Vehicles in Experimental Gliomas

(2008) Daniel Bexell et al.   MOLECULAR THERAPY

Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM

(2008) Rose Du et al.   NEURO-ONCOLOGY

Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence

(2008) A. D. Norden et al.   NEUROLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hematopoietic Stem Cell–Derived Pericytic Cells in Brain Tumor Angio-Architecture

(2008) Simon R. Bababeygy et al.   STEM CELLS AND DEVELOPMENT

The Cancer Stem Cell–Vascular Niche Complex in Brain Tumor Formation

(2008) Anand Veeravagu et al.   STEM CELLS AND DEVELOPMENT

From bone marrow to microglia: barriers and avenues

(2008) Nathalie Davoust et al.   TRENDS IN IMMUNOLOGY

Circulating bone marrow-derived endothelial progenitor cells: Characterization, mobilization, and therapeutic considerations in malignant disease

(2007) Balazs Dome et al.   CYTOMETRY PART A