Hepatocellular carcinoma: Therapeutic advances in signaling, epigenetic and immune targets
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Title
Hepatocellular carcinoma: Therapeutic advances in signaling, epigenetic and immune targets
Authors
Keywords
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Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 25, Issue 25, Pages 3136-3150
Publisher
Baishideng Publishing Group Inc.
Online
2019-07-04
DOI
10.3748/wjg.v25.i25.3136
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Note: Only part of the references are listed.- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
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- Diethylnitrosamine enhances hepatic tumorigenic pathways in mice fed with high fat diet (Hfd)
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- Screening and function analysis of hub genes and pathways in hepatocellular carcinoma via bioinformatics approaches
- (2018) Liang Zhang et al. Cancer Biomarkers
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- Chimeric antigen receptor-engineered T-cell therapy for liver cancer
- (2018) Yang Chen et al. Hepatobiliary & Pancreatic Diseases International
- Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma
- (2018) Mohamed Bouattour et al. HEPATOLOGY
- Expression of programmed death ligand-1 and programmed death 1 in hepatocellular carcinoma and its clinical significance
- (2018) Yan-Hua Xu et al. Journal of Cancer Research and Therapeutics
- Immune checkpoint therapy in liver cancer
- (2018) Feng Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Preclinical models of non-alcoholic fatty liver disease
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- Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
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- Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research
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- Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
- (2018) Ghassan K. Abou-Alfa et al. NEW ENGLAND JOURNAL OF MEDICINE
- Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling
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- Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma
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- Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice
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- Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma
- (2018) Iftikhar Ali Khawar et al. NEOPLASIA
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
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- Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial
- (2018) Roser Pinyol et al. GUT
- Phase I/II study of first-line combination therapy with sorafenib plus resminostat, an oral HDAC inhibitor, versus sorafenib monotherapy for advanced hepatocellular carcinoma in east Asian patients
- (2018) Won Young Tak et al. INVESTIGATIONAL NEW DRUGS
- Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer
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- Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications
- (2018) Javier A García-Vilas et al. WORLD JOURNAL OF GASTROENTEROLOGY
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- (2018) Diana Llopiz et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
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- (2016) Yukihiro Haruyama WORLD JOURNAL OF GASTROENTEROLOGY
- Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
- (2016) Roberta Montalbano et al. Oncotarget
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- Evaluating clinical and prognostic implications of Glypican-3 in hepatocellular carcinoma
- (2016) Ahmed Omar Kaseb et al. Oncotarget
- Management of hepatocellular carcinoma: an overview of major findings from meta-analyses
- (2016) Xingshun Qi et al. Oncotarget
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- (2015) Viswanath Das et al. DRUG DISCOVERY TODAY
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- (2015) Quangui Sun et al. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
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- SEARCH: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Sorafenib Plus Erlotinib in Patients With Advanced Hepatocellular Carcinoma
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- Sorafenib for the treatment of hepatocellular carcinoma with portal vein tumour thrombosis: a systematic review of comparative studies
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- MET inhibitors for treatment of advanced hepatocellular carcinoma: A review
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- (2014) S. Mokkapati et al. CANCER RESEARCH
- Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
- (2014) H. Gao et al. CLINICAL CANCER RESEARCH
- Hepatocellular Carcinoma: Reasons for Phase III Failure and Novel Perspectives on Trial Design
- (2014) J. M. Llovet et al. CLINICAL CANCER RESEARCH
- Early to Phase II drugs currently under investigation for the treatment of liver fibrosis
- (2014) Peter Hauff et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Additive antitumour response to the rabbit VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulation
- (2014) Barbara Behm et al. GUT
- Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis and tumorigenesis
- (2014) Marian Kampschulte et al. LABORATORY INVESTIGATION
- Pathological Impact of Hepatitis B Virus Surface Proteins on the Liver Is Associated with the Host Genetic Background
- (2014) Yuri Churin et al. PLoS One
- Hepatocellular Carcinoma with Portal Vein Tumor Thrombus: Treatment with Transarterial Chemoembolization Combined with Sorafenib—A Retrospective Controlled Study
- (2014) Kangshun Zhu et al. RADIOLOGY
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- (2014) Roberta Montalbano et al. Translational Oncology
- Practical Effect of Sorafenib Monotherapy on Advanced Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis
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- Brivanib Versus Sorafenib As First-Line Therapy in Patients With Unresectable, Advanced Hepatocellular Carcinoma: Results From the Randomized Phase III BRISK-FL Study
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- Combination of the Deacetylase Inhibitor Panobinostat and the Multi-Kinase Inhibitor Sorafenib for the Treatment of Metastatic Hepatocellular Carcinoma - Review of the Underlying Molecular Mechanisms and First Case Report
- (2012) Susanne Gahr et al. Journal of Cancer
- Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC
- (2011) Karl Quint et al. VIRCHOWS ARCHIV
- Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions
- (2009) K. Wu et al. CANCER RESEARCH
- Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma
- (2009) Y. Hoshida et al. CANCER RESEARCH
- Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma
- (2008) D. Y. Chiang et al. CANCER RESEARCH
- Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
- (2008) Ann-Lii Cheng et al. LANCET ONCOLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
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