Dimensions of hepatocellular carcinoma phenotypic diversity

Systemic therapy for intermediate and advanced hepatocellular carcinoma: Sorafenib and beyond

(2018) Jean-Luc Raoul et al.   CANCER TREATMENT REVIEWS

Hepatocellular carcinoma in the era of immunotherapy

(2018) Hao-Wen Sim et al.   CURRENT PROBLEMS IN CANCER

β-catenin-activated hepatocellular carcinomas are addicted to fatty acids

(2018) Nadia Senni et al.   GUT

A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

(2018) Ping Luo et al.   HEPATOLOGY

Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance

(2018) Marianne Ziol et al.   HEPATOLOGY

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation

(2018) Shirley Abitbol et al.   JOURNAL OF HEPATOLOGY

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2018) Peter R. Galle et al.   JOURNAL OF HEPATOLOGY

The immunology of hepatocellular carcinoma

(2018) Marc Ringelhan et al.   NATURE IMMUNOLOGY

Does Y90 Radioembolization Prolong Overall Survival Compared With Chemoembolization in Patients With Hepatocellular Carcinoma?

(2017) Etienne Garin et al.   GASTROENTEROLOGY

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Human hepatocellular carcinomas with a periportal phenotype have the lowest potential for early recurrence after curative resection

(2017) Romain Désert et al.   HEPATOLOGY

Molecular classification of hepatocellular carcinoma: The view from metabolic zonation

(2017) Charlotte K.Y. Ng et al.   HEPATOLOGY

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

(2017) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

(2017) Sara Torrecilla et al.   JOURNAL OF HEPATOLOGY

Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

(2017) Valérie Vilgrain et al.   LANCET ONCOLOGY

Liver cancer: Translating '–omics' results into precision medicine for hepatocellular carcinoma

(2017) Daniela Sia et al.   Nature Reviews Gastroenterology & Hepatology

Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches

(2017) Gonzalo Sapisochin et al.   Nature Reviews Gastroenterology & Hepatology

The emerging role and targetability of the TCA cycle in cancer metabolism

(2017) Nicole M. Anderson et al.   Protein & Cell

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

(2017) Stefanie J. Hectors et al.   Scientific Reports

Regulation of Transdifferentiation and Retrodifferentiation by Inflammatory Cytokines in Hepatocellular Carcinoma

(2016) Florian Cabillic et al.   GASTROENTEROLOGY

Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma

(2016) Riad Salem et al.   GASTROENTEROLOGY

Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma

(2016) Jordi Bruix et al.   GASTROENTEROLOGY

Variable Intra-Tumor Genomic Heterogeneity of Multiple Lesions in Patients With Hepatocellular Carcinoma

(2016) Ruidong Xue et al.   GASTROENTEROLOGY

Genotype-phenotype correlation ofCTNNB1mutations reveals different ß-catenin activity associated with liver tumor progression

(2016) Sandra Rebouissou et al.   HEPATOLOGY

“Fibrous nests” in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome

(2016) Romain Désert et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The transcriptomic G1–G6 signature of hepatocellular carcinoma in an Asian population

(2016) John Carson Allen et al.   MEDICINE

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(2016) Akihiro Fujimoto et al.   NATURE GENETICS

Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects

(2016) Run-Ze Shang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas

(2016) Sihem Mebarki et al.   Oncotarget

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Intratumor Molecular and Phenotypic Diversity in Hepatocellular Carcinoma

(2015) J.-C. Nault et al.   CLINICAL CANCER RESEARCH

Genetic Landscape and Biomarkers of Hepatocellular Carcinoma

(2015) Jessica Zucman-Rossi et al.   GASTROENTEROLOGY

Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study

(2015) Erica Villa et al.   GUT

Progenitor cell markers predict outcome of patients with hepatocellular carcinoma beyond Milan criteria undergoing liver transplantation

(2015) Oriana Miltiadous et al.   JOURNAL OF HEPATOLOGY

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Advances in targeted therapies for hepatocellular carcinoma in the genomic era

(2015) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Genomic Profiling of Hepatocellular Adenomas Reveals Recurrent FRK-Activating Mutations and the Mechanisms of Malignant Transformation

(2014) Camilla Pilati et al.   CANCER CELL

Intratumor Heterogeneity in Hepatocellular Carcinoma

(2014) J. Friemel et al.   CLINICAL CANCER RESEARCH

Hepatic Fibrosis and the Microenvironment: Fertile Soil for Hepatocellular Carcinoma Development

(2014) Michael C. Wallace et al.   GENE EXPRESSION

Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma

(2014) Taro Yamashita et al.   HEPATOLOGY

Deciphering liver zonation: New insights into the β-catenin, Tcf4, and HNF4α triad

(2014) Carmen Berasain et al.   HEPATOLOGY

Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells

(2014) Hélène Dubois-Pot-Schneider et al.   HEPATOLOGY

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

(2014) Jean Charles Nault et al.   HEPATOLOGY

OATP1B3 expression is strongly associated with Wnt/β-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma

(2014) Akihisa Ueno et al.   JOURNAL OF HEPATOLOGY

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

(2014) Supriya K. Saha et al.   NATURE

Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics

(2013) Q. Huang et al.   CANCER RESEARCH

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

(2013) Z. Kan et al.   GENOME RESEARCH

Tissue metabolomics of hepatocellular carcinoma: Tumor energy metabolism and the role of transcriptomic classification

(2013) Diren Beyoğlu et al.   HEPATOLOGY

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

(2013) Angélique Gougelet et al.   HEPATOLOGY

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib

(2012) A. Lachenmayer et al.   CLINICAL CANCER RESEARCH

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration

(2012) Douglas G. Altman et al.   PLOS MEDICINE

Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma

(2011) Augusto Villanueva et al.   GASTROENTEROLOGY

Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/ -catenin signalling pathway

(2011) L. Fu et al.   GUT

Gene-expression signature of vascular invasion in hepatocellular carcinoma

(2011) Beatriz Mínguez et al.   JOURNAL OF HEPATOLOGY

A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients

(2010) S. Roessler et al.   CANCER RESEARCH

Identification of a Cholangiocarcinoma-Like Gene Expression Trait in Hepatocellular Carcinoma

(2010) H. G. Woo et al.   CANCER RESEARCH

Role of p53 and β-catenin Mutations in Conjunction with CK19 Expression on Early Tumor Recurrence and Prognosis of Hepatocellular Carcinoma

(2010) Ray-Hwang Yuan et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

(2009) Y. Hoshida et al.   CANCER RESEARCH

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

(2008) A Bengochea et al.   BRITISH JOURNAL OF CANCER

EpCAM and  -Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

(2008) T. Yamashita et al.   CANCER RESEARCH

Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma

(2008) D. Y. Chiang et al.   CANCER RESEARCH

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY

Transforming growth factor-β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

(2008) Cédric Coulouarn et al.   HEPATOLOGY

Liver-Specific Hepatocyte Nuclear Factor-4α Deficiency: Greater Impact on Gene Expression in Male than in Female Mouse Liver

(2008) Minita G. Holloway et al.   MOLECULAR ENDOCRINOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sorafenib in Liver Cancer — Just the Beginning

(2008) Lewis R. Roberts   NEW ENGLAND JOURNAL OF MEDICINE

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE