CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success
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Title
CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-12-03
DOI
10.3389/fimmu.2018.02740
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Note: Only part of the references are listed.- Role of prostaglandins in tumor microenvironment
- (2018) Koji Kobayashi et al. CANCER AND METASTASIS REVIEWS
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- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
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- (2018) Li Tang et al. NATURE BIOTECHNOLOGY
- Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
- (2018) Nikolaos Zacharakis et al. NATURE MEDICINE
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- Chimeric Antigen Receptor Therapy
- (2018) Carl H. June et al. NEW ENGLAND JOURNAL OF MEDICINE
- Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
- (2018) Jae H. Park et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
- (2018) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- The epigenetic control of stemness in CD8+T cell fate commitment
- (2018) Luigia Pace et al. SCIENCE
- Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy
- (2018) Serena Pellegatta et al. Science Translational Medicine
- Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager
- (2018) Anna Wing et al. Cancer Immunology Research
- Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells
- (2018) Saba Ghassemi et al. Cancer Immunology Research
- Reprogramming human T cell function and specificity with non-viral genome targeting
- (2018) Theodore L. Roth et al. NATURE
- Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
- (2018) Joseph A. Fraietta et al. NATURE
- Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
- (2018) Sarwish Rafiq et al. NATURE BIOTECHNOLOGY
- CAR T-cell therapy of solid tumors
- (2017) Carmen S M Yong et al. IMMUNOLOGY AND CELL BIOLOGY
- Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
- (2017) Justin Eyquem et al. NATURE
- Origin and differentiation of human memory CD8 T cells after vaccination
- (2017) Rama S. Akondy et al. NATURE
- Effector CD8 T cells dedifferentiate into long-lived memory cells
- (2017) Ben Youngblood et al. NATURE
- Chromatin states define tumour-specific T cell dysfunction and reprogramming
- (2017) Mary Philip et al. NATURE
- Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas
- (2017) Stephen J. Schuster et al. NEW ENGLAND JOURNAL OF MEDICINE
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
- (2017) Sanja Stevanović et al. SCIENCE
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- (2017) Donald M. O’Rourke et al. Science Translational Medicine
- Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells
- (2017) Marco Ruella et al. Cancer Discovery
- A versatile system for rapid multiplex genome-edited CAR T cell generation
- (2017) Jiangtao Ren et al. Oncotarget
- Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment
- (2017) Oladapo O. Yeku et al. Scientific Reports
- Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
- (2017) Biliang Hu et al. Cell Reports
- CARs in the Lead Against Multiple Myeloma
- (2017) Maria Ormhøj et al. Current Hematologic Malignancy Reports
- Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants
- (2017) Giedre Krenciute et al. Cancer Immunology Research
- PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells
- (2017) Jacob S. Bowers et al. Frontiers in Immunology
- Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications
- (2017) Hamid R. Mirzaei et al. Frontiers in Immunology
- Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don’t Forget the Fuel
- (2017) Melita Irving et al. Frontiers in Immunology
- PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR
- (2016) Elise A. Chong et al. BLOOD
- From transformation to metastasis: deconstructing the extracellular matrix in breast cancer
- (2016) Shelly Kaushik et al. CANCER AND METASTASIS REVIEWS
- A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
- (2016) Xiaojun Liu et al. CANCER RESEARCH
- Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits
- (2016) Kole T. Roybal et al. CELL
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy
- (2016) Madhusudhanan Sukumar et al. Cell Metabolism
- Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
- (2016) Johannes Schödel et al. EUROPEAN UROLOGY
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- (2016) Omkar U. Kawalekar et al. IMMUNITY
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- (2016) Avery D. Posey et al. IMMUNITY
- How Chimeric Antigen Receptor Design Affects Adoptive T Cell Therapy
- (2016) Albert T. Gacerez et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2016) Carlos A. Ramos et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2016) Yuki Kagoya et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2016) Petros A. Tyrakis et al. NATURE
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- (2016) Alena Gros et al. NATURE MEDICINE
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- (2016) Eric Tran et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2015) Rachel A. Burga et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
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- CAR T-Cell Therapy: The Role of Physical Barriers and Immunosuppression in Lymphoma
- (2015) Gunilla Enblad et al. HUMAN GENE THERAPY
- Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
- (2015) Cyrille J. Cohen et al. JOURNAL OF CLINICAL INVESTIGATION
- Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
- (2015) Christopher A. Klebanoff et al. JOURNAL OF CLINICAL INVESTIGATION
- Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
- (2015) Nabil Ahmed et al. JOURNAL OF CLINICAL ONCOLOGY
- Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity
- (2015) Maarten A. Ligtenberg et al. JOURNAL OF IMMUNOLOGY
- Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
- (2015) Ignazio Caruana et al. NATURE MEDICINE
- Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma
- (2015) Alfred L. Garfall et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immunogenicity of somatic mutations in human gastrointestinal cancers
- (2015) E. Tran et al. SCIENCE
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- (2015) Laura A. Johnson et al. Science Translational Medicine
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- (2015) David L. Porter et al. Science Translational Medicine
- Targeting T cell metabolism for therapy
- (2015) David O'Sullivan et al. TRENDS IN IMMUNOLOGY
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- (2015) Angela Cho et al. Frontiers in Oncology
- Adoptive Immunotherapy for Cancer or Viruses
- (2014) Marcela V. Maus et al. Annual Review of Immunology
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- (2014) Y. Xu et al. BLOOD
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
- (2014) J. G. Crompton et al. CANCER RESEARCH
- Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
- (2014) Y.-C. Lu et al. CLINICAL CANCER RESEARCH
- Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors
- (2014) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
- (2014) Mako Nakaya et al. IMMUNITY
- PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
- (2014) Alena Gros et al. JOURNAL OF CLINICAL INVESTIGATION
- Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor
- (2014) S. Wilkie et al. JOURNAL OF IMMUNOLOGY
- Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
- (2014) Gregory T Motz et al. NATURE MEDICINE
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer
- (2014) E. Tran et al. SCIENCE
- Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
- (2014) P. S. Adusumilli et al. Science Translational Medicine
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells
- (2013) L. B. John et al. CLINICAL CANCER RESEARCH
- Genetically modified T cells targeting neovasculature efficiently destroy tumor blood vessels, shrink established solid tumors and increase nanoparticle delivery
- (2013) Xinping Fu et al. INTERNATIONAL JOURNAL OF CANCER
- Reassessing target antigens for adoptive T-cell therapy
- (2013) Christian S Hinrichs et al. NATURE BIOTECHNOLOGY
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
- (2013) Paul F Robbins et al. NATURE MEDICINE
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
- (2013) G. J. W. van der Windt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
- (2013) L.-C. S. Wang et al. Cancer Immunology Research
- Clinical Implications of Co-Inhibitory Molecule Expression in the Tumor Microenvironment for DC Vaccination: A Game of Stop and Go
- (2013) Angela Vasaturo et al. Frontiers in Immunology
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice
- (2012) D. Chinnasamy et al. CLINICAL CANCER RESEARCH
- Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
- (2012) Christopher C Kloss et al. NATURE BIOTECHNOLOGY
- Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
- (2012) T. Stylianopoulos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
- (2011) C. U. Louis et al. BLOOD
- Targeting Regulatory T Cells in Cancer
- (2011) W. L. Byrne et al. CANCER RESEARCH
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
- (2011) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
- (2011) Barbara Savoldo et al. JOURNAL OF CLINICAL INVESTIGATION
- A human memory T cell subset with stem cell–like properties
- (2011) Luca Gattinoni et al. NATURE MEDICINE
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
- (2011) David L. Porter et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pancreatic Cancer: Pathobiology, Treatment Options, and Drug Delivery
- (2010) Jing Li et al. AAPS Journal
- Reprogramming of T Cells from Human Peripheral Blood
- (2010) Yuin-Han Loh et al. Cell Stem Cell
- Adenosine and Prostaglandin E2Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells
- (2010) Magis Mandapathil et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhanced Tumor Trafficking of GD2 Chimeric Antigen Receptor T Cells by Expression of the Chemokine Receptor CCR2b
- (2010) John A. Craddock et al. JOURNAL OF IMMUNOTHERAPY
- Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
- (2010) Richard A Morgan et al. MOLECULAR THERAPY
- Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
- (2009) Zhizhong Li et al. CANCER CELL
- Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment
- (2009) H. Harlin et al. CANCER RESEARCH
- Anergic T Cells Are Metabolically Anergic
- (2009) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
- (2009) Michael C. Milone et al. MOLECULAR THERAPY
- Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
- (2009) Luca Gattinoni et al. NATURE MEDICINE
- Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
- (2009) G L Semenza ONCOGENE
- Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
- (2009) C. Carpenito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes
- (2008) S. Kaneko et al. BLOOD
- Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
- (2008) Martin A Pule et al. NATURE MEDICINE
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