Engineering H5N1 avian influenza viruses to study human adaptation

Dangerous for ferrets: lethal for humans?

(2013) Peter C Doherty et al.   BMC BIOLOGY

Don't censor life-saving science

(2012) Peter Palese   NATURE

The fight over flu

(2012)   NATURE

IFITM3 restricts the morbidity and mortality associated with influenza

(2012) Aaron R. Everitt et al.   NATURE

Avian Influenza H5N1 Transmission in Households, Indonesia

(2012) Tjandra Y. Aditama et al.   PLoS One

Exhaled Aerosol Transmission of Pandemic and Seasonal H1N1 Influenza Viruses in the Ferret

(2012) Frederick Koster et al.   PLoS One

H5N1 influenza viruses: Facts, not fear

(2012) P. Palese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis

(2012) T. T. Wang et al.   SCIENCE

Pause on Avian Flu Transmission Research

(2012) R. A. M. Fouchier et al.   SCIENCE

Mammalian-Transmissible H5N1 Influenza: the Dilemma of Dual-Use Research

(2012) R. G. Webster   mBio

Mammalian-Transmissible H5N1 Influenza: Facts and Perspective

(2012) M. T. Osterholm et al.   mBio

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

Risk Factors for Cluster Outbreaks of Avian Influenza A H5N1 Infection, Indonesia

(2011) T. Y. Aditama et al.   CLINICAL INFECTIOUS DISEASES

The ferret as a model organism to study influenza A virus infection

(2011) J. A. Belser et al.   Disease Models & Mechanisms

The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals

(2011) A. L. Suguitan et al.   JOURNAL OF VIROLOGY

Reversion of PB2-627E to -627K during Replication of an H5N1 Clade 2.2 Virus in Mammalian Hosts Depends on the Origin of the Nucleoprotein

(2011) J. Bogs et al.   JOURNAL OF VIROLOGY

The Virulence of 1997 H5N1 Influenza Viruses in the Mouse Model Is Increased by Correcting a Defect in Their NS1 Proteins

(2011) A. Spesock et al.   JOURNAL OF VIROLOGY

Potential role of human challenge studies for investigation of influenza transmission

(2011) Ben Killingley et al.   LANCET INFECTIOUS DISEASES

Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model

(2011) J. B. Kimble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding

(2011) Li Qi et al.   VIROLOGY

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses

(2011) Taronna R. Maines et al.   VIROLOGY

In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity

(2011) Li-Mei Chen et al.   VIROLOGY

Insights on influenza pathogenesis from the grave

(2011) Jeffery K. Taubenberger et al.   VIRUS RESEARCH

Eurasian-Origin Gene Segments Contribute to the Transmissibility, Aerosol Release, and Morphology of the 2009 Pandemic H1N1 Influenza Virus

(2011) Seema S. Lakdawala et al.   PLoS Pathogens

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

The 1918 influenza pandemic: Lessons for 2009 and the future

(2010) David M. Morens et al.   CRITICAL CARE MEDICINE

What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?

(2010) P. HORBY et al.   EPIDEMIOLOGY AND INFECTION

Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine

(2010) David M. Morens et al.   Influenza and Other Respiratory Viruses

Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5

(2010) S. Gohrbandt et al.   JOURNAL OF GENERAL VIROLOGY

MultiDrug-Resistant 2009 Pandemic Influenza A(H1N1) Viruses Maintain Fitness and Transmissibility in Ferrets

(2010) Matthew J. Memoli et al.   JOURNAL OF INFECTIOUS DISEASES

Glycosylation at 158N of the Hemagglutinin Protein and Receptor Binding Specificity Synergistically Affect the Antigenicity and Immunogenicity of a Live Attenuated H5N1 A/Vietnam/1203/2004 Vaccine Virus in Ferrets

(2010) W. Wang et al.   JOURNAL OF VIROLOGY

Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein

(2010) Florian Zielecki et al.   JOURNAL OF VIROLOGY

Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets

(2010) G. L. Chen et al.   JOURNAL OF VIROLOGY

Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957

(2010) Claudia Pappas et al.   PLoS One

Highly Pathogenic H5N1 Influenza Viruses Carry Virulence Determinants beyond the Polybasic Hemagglutinin Cleavage Site

(2010) Jessica Bogs et al.   PLoS One

Antigenic Epitopes in the Hemagglutinin of Qinghai-Type Influenza H5N1 Virus

(2010) Irina A. Rudneva et al.   VIRAL IMMUNOLOGY

The 2009 H1N1 Pandemic Influenza Virus: What Next?

(2010) D. M. Morens et al.   mBio

Pathological lesions and viral localization of Influenza A (H5N1) virus in experimentally infected Chinese rhesus macaques: implications for pathogenesis and viral transmission

(2009) Yunxin Chen et al.   ARCHIVES OF VIROLOGY

Systems-based candidate genes for human response to influenza infection

(2009) Lyna Zhang et al.   INFECTION GENETICS AND EVOLUTION

Characterization of the H5N1 Highly Pathogenic Avian Influenza Virus Derived from Wild Pikas in China

(2009) J. Zhou et al.   JOURNAL OF VIROLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009

(2009) Vivek Shinde et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Persistent Legacy of the 1918 Influenza Virus

(2009) David M. Morens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air

(2009) N. Van Hoeven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus

(2009) E. M. Sorrell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and immunogenicity of a subvirion inactivated influenza A/H5N1 vaccine with or without aluminum hydroxide among healthy elderly adults

(2009) Rebecca C. Brady et al.   VACCINE

An early ‘classical’ swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice

(2009) Matthew J. Memoli et al.   VIROLOGY

Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity

(2009) Haichen Song et al.   Virology Journal

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

Genetic susceptibility and resistance to influenza infection and disease in humans and mice

(2008) Rita A Trammell et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Cross-Species Virus Transmission and the Emergence of New Epidemic Diseases

(2008) C. R. Parrish et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread

(2008) H.-L. Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

(2008) C. Pappas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets

(2008) T. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human-Like Receptor Specificity Does Not Affect the Neuraminidase-Inhibitor Susceptibility of H5N1 Influenza Viruses

(2008) Natalia A. Ilyushina et al.   PLoS Pathogens