Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients

(2015) Yohei Watanabe et al.   mBio

Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus

(2015) Andrew S. Taft et al.   Nature Communications

Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 Virus

(2014) Martin Linster et al.   CELL

Genetic tuning of the novel avian influenza A(H7N9) virus during interspecies transmission, China, 2013

(2014) D Wang et al.   Eurosurveillance

Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic subclade

(2014) R. El-Shesheny et al.   JOURNAL OF GENERAL VIROLOGY

Viral determinants of influenza A virus host range

(2014) A. V. Cauldwell et al.   JOURNAL OF GENERAL VIROLOGY

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

At the centre: influenza A virus ribonucleoproteins

(2014) Amie J. Eisfeld et al.   NATURE REVIEWS MICROBIOLOGY

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication

(2014) Wenjun Song et al.   Nature Communications

Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts

(2014) Shufang Fan et al.   Nature Communications

Transmission of influenza A/H5N1 viruses in mammals

(2013) M. Imai et al.   VIRUS RESEARCH

Investigation of Influenza Virus Polymerase Activity in Pig Cells

(2012) O. Moncorge et al.   JOURNAL OF VIROLOGY

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

Egyptian H5N1 Influenza Viruses—Cause for Concern?

(2012) Gabriele Neumann et al.   PLoS Pathogens

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

Genetic diversification of H5N1 highly pathogenic avian influenza A virus during replication in wild ducks

(2011) Y. Watanabe et al.   JOURNAL OF GENERAL VIROLOGY

The changing nature of avian influenza A virus (H5N1)

(2011) Yohei Watanabe et al.   TRENDS IN MICROBIOLOGY

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt

(2011) Yohei Watanabe et al.   PLoS Pathogens

Evolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variants

(2010) G. Neumann et al.   JOURNAL OF GENERAL VIROLOGY

Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase

(2010) O. Moncorge et al.   JOURNAL OF VIROLOGY

Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence

(2010) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

(2010) Shinya Yamada et al.   PLoS Pathogens

Molecular Determinants of Adaptation of Highly Pathogenic Avian Influenza H7N7 Viruses to Efficient Replication in the Human Host

(2009) E. de Wit et al.   JOURNAL OF VIROLOGY

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

Host Restriction of Avian Influenza Viruses at the Level of the Ribonucleoproteins

(2008) Nadia Naffakh et al.   Annual Review of Microbiology

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens