Article
Pharmacology & Pharmacy
Hassan Aouad, Quentin Faucher, Francois-Ludovic Sauvage, Emilie Pinault, Claire-Cecile Barrot, Helene Arnion, Marie Essig, Pierre Marquet
Summary: This study aims to detect off-target pathways modulated by tacrolimus that can explain its nephrotoxicity using a multiomics approach on a lineage of proximal tubular cells.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi
Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Asok K. Dasmahapatra, Paul B. Tchounwou
Summary: In this study, the effects of graphene oxide (GO) as an endocrine disrupting chemical (EDC) on the endocrine pancreas of Japanese medaka adults were investigated. It was found that GO exposure enhanced immunoreactivity in the islet organs, and the impairments in the pancreas were inconsistent and influenced by exposure routes and sex of the fish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Computer Science, Interdisciplinary Applications
G. R. Brindha, B. S. Rishiikeshwer, B. Santhi, K. Nakendraprasath, R. Manikandan, Amir H. Gandomi
Summary: In this study, machine learning models were developed and validated to predict the efficacy of five anti-cancer drugs based on the clinical and molecular attributes of oral squamous cell carcinoma (OSCC) cohorts. The models achieved enhanced accuracy by introducing novel pre-processing techniques.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Rigoberto Oros-Pantoja, Julio Cesar Cordoba-Adaya, Eugenio Torres-Garcia, Enrique Morales-Avila, Liliana Aranda-Lara, Jonnathan G. Santillan-Benitez, Mariana Sanchez-Holguin, Neri O. Hernandez-Herrera, Gloria Otero, Keila Isaac-Olive
Summary: Although liposomal doxorubicin (LPD) is widely used for cancer treatment, the toxicity it induces in healthy organs and tissues remains limited. This study used the biodistribution of Ga-67-citrate to evaluate the toxicity of LPD in healthy male and female mice. The results highlight the significance of Ga-67-citrate and the importance of considering gender in toxicological evaluations of drugs.
Article
Multidisciplinary Sciences
Arnon Moldrup Knudsen, Henning Bunsow Boldt, Elisabeth Victoria Jakobsen, Bjarne Winther Kristensen
Summary: The multi-target small-molecule inhibitor SB747651A showed anticancer effects in glioblastoma by reducing cell proliferation, migration, and chemoresistance, inducing apoptotic cell death, and prolonging survival in mice with intracranial glioblastoma xenografts. Further research is needed to clarify its mechanisms of action before potential clinical application as an anticancer agent.
SCIENTIFIC REPORTS
(2021)
Review
Engineering, Biomedical
Rick Xing Ze Lu, Milica Radisic
Summary: Nanoparticles have raised concerns due to potential adverse health effects, necessitating the development of physiologically relevant models for toxicity assessment. Organ-on-a-chip models offer a new avenue for nanotoxicological research by recapitulating in vivo microenvironment and responses.
BIOACTIVE MATERIALS
(2021)
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Minhaj Ahmad Khan, Rajnish Kumar, Tarun Kumar Upadhyay
Summary: Apitherapy using bee products, especially honeybee venom, has gained recognition globally in cancer therapeutics. Bee products, including honeybee venom, have shown significant potential in strengthening the immune system and improving human health.
Article
Biochemistry & Molecular Biology
Samir H. Barghout, Mandeep K. Mann, Ahmed Aman, Yifan Yu, Matthew G. Alteen, Aaron D. Schimmer, Matthieu Schapira, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Summary: This study identified epigenetic probes that significantly enhance the cytotoxicity of TAK-243 through off-target ABCG2 inhibition. A cell-based assay was developed to quantitatively evaluate ABCG2 inhibition by drug candidates based on the potentiation of TAK-243 cytotoxicity.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samir H. Barghout, Mandeep K. Mann, Ahmed Aman, Yifan Yu, Matthew G. Alteen, Aaron D. Schimmer, Matthieu Schapira, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Summary: This study identifies epigenetic regulators that can significantly enhance the cytotoxicity of the anticancer drug TAK-243. These regulators exert their effects by inhibiting the efflux transporter ABCG2. The study also develops a cell-based assay to quantitatively evaluate the ABCG2-inhibitory activity of drug candidates.
ACS CHEMICAL BIOLOGY
(2022)
Article
Engineering, Environmental
Sungjae Park, Kishwor Poudel, Jiseok Lim, Jaeho Oh, Sae Kwang Ku, Jungho Hwang, Jong Oh Kim, Jeong Hoon Byeon
Summary: Nanoscale supraparticles with affordable structures have gained significant attention in cancer therapy and diagnosis for combinatorial theranostics. However, there is a lack of studies on assembling cancer theranostic supraparticles in an aerosol state. Aerosol additive manufacturing using electrically operable devices offers a digitizable platform for the spontaneous assembly of multi-component supraparticles in a continuous medium. Thus, it provides a promising approach for the development of efficient cancer therapeutics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Integrative & Complementary Medicine
Yaoxia Jia, Xing Li, Xiangqi Meng, Jinjie Lei, Yangmiao Xia, Lingying Yu
Summary: This review focuses on the anti-cancer attributes, mechanism, and regulation of related signaling pathways of 6-shogaol. Furthermore, it discusses its synergy with commonly used anticancer drugs, potential drug delivery systems, and prospects for future research. This comprehensive review aims to provide a theoretical basis and guiding significance for the future anti-cancer research and clinical development of 6-shogaol.
Article
Pharmacology & Pharmacy
Nikhil Biswas, Aiman Abu Ammar, Marina Frusic-Zlotkin, Naama Adi-Hen, Yonat Lehman-Katabi, Yael Levi-Kalisman, Taher Nassar, Simon Benita
Summary: Oxaliplatin palmitate acetate (OPA), a platinum (IV) oxaliplatin derivative, showed higher toxicity in in vitro and in vivo studies compared to oxaliplatin, but was not considered a prodrug of oxaliplatin. The release of OPA from nanoparticles did not prolong in the plasma, and both OPA solution and OPA nanoparticles demonstrated promising antitumor efficacy in various cancer models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ivan Ortega-Blake, Mario Fernandez-Zertuche, Ignacio Regla, Walfred Sanchez-Pena, Antonieta Gomez-Solis, Paola Jaimes-Chavez, Arturo Galvan-Hernandez, Erika Tovar-Garduno, Lourdes Rodriguez-Fragoso
Summary: The safety of Amphotericin A21 (AmB-A21) was evaluated through chronic toxicity, targeted organ toxicity, and dermal irritation studies. The results showed potential testicle damage with long-term use, which reversed after discontinuation of treatment. Dermal irritation study revealed potential skin reactions at higher doses, along with effects on liver enzymes and renal function. Based on the findings, AmB-21 could be a safe option for long-term antifungal treatment with reduced side effects.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Daranjit Sandhu, Albert A. Antolin, Anthony R. Cox, Alan M. Jones
Summary: Despite their similar mode of action, the polypharmacology of PARP inhibitors influences their ADR profile.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Chemistry, Analytical
Jong Hwan Sung, Ying I. Wang, Narasimhan Narasimhan Sriram, Max Jackson, Christopher Long, James J. Hickman, Michael L. Shuler
ANALYTICAL CHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Paula G. Miller, Chen-Yu Chen, Ying Wang, Emily Gao, Michael L. Shuler
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Biotechnology & Applied Microbiology
Sarah A. Najjar, Alexander S. T. Smith, Christopher J. Long, Christopher W. McAleer, Yunqing Cai, Balaji Srinivasan, Candace Martin, Herman H. Vandenburgh, James J. Hickman
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Trevor Sasserath, John W. Rumsey, Christopher W. McAleer, Lee Richard Bridges, Christopher J. Long, Daniel Elbrecht, Franz Schuler, Adrian Roth, Christina Bertinetti-LaPatki, Michael L. Shuler, James J. Hickman
Article
Engineering, Industrial
Dayue Jiang, Fuda Ning, Ying Wang
Summary: The study showed that PLA-based composite scaffolds with optimized printing parameters have accurate pore dimensions and evenly distributed iron-based powders, with lower thermal expansion coefficients, enhanced mechanical properties, reduced surface roughness, and superior degradation resistance, wetting behavior, and cytocompatibility. These results demonstrate the potential of PLA/iron scaffolds in bone tissue engineering applications.
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yan Chen, Liyuan Wang, Ying Wang, Yingge Zhou
Summary: Vascular tissue engineering is a promising approach for viable artificial tissues and organs. In this study, researchers used electrospinning to fabricate microtubes to mimic capillary vessels, which were then embedded in a hydrogel for bioprinting. The results showed improved printing fidelity and cell attachment. The concentration and length of the microtubes had significant effects on filament size and merging area. In vitro experiments demonstrated the compatibility of the microtubes with cells and their ability to promote cell proliferation and morphogenesis.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Trevor Sasserath, Ashley L. Robertson, Roxana Mendez, Tristan T. Hays, Ethan Smith, Helena Cooper, Nesar Akanda, John W. Rumsey, Xiufang Guo, Atena Farkhondeh, Manisha Pradhan, Karsten Baumgaertel, Matthew Might, Steven Rodems, Wei Zheng, James J. Hickman
Summary: This study establishes a disease model for NGLY1 deficiency by differentiating patient-derived iPSCs into MNs. Multiple deficits are observed in NGLY1-deficient MNs, and functional differences between healthy and diseased NMJs are studied using a NMJ coculture system.
ADVANCED THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
John W. Rumsey, Case Lorance, Max Jackson, Trevor Sasserath, Christopher W. McAleer, Christopher J. Long, Arindom Goswami, Melissa A. Russo, Shruti M. Raja, Karissa L. Gable, Doug Emmett, Lisa D. Hobson-Webb, Manisha Chopra, James F. Howard, Jeffrey T. Guptill, Michael J. Storek, Miguel Alonso-Alonso, Nazem Atassi, Sandip Panicker, Graham Parry, Timothy Hammond, James J. Hickman
Summary: The authors describe a human-on-a-chip electrical conduction model to study chronic autoimmune demyelinating neuropathies and investigate the efficacy of TNT005 in rescuing the pathological effects. Patient sera containing autoantibodies activate the classical complement pathway, leading to neurophysiological features of the diseases. Complement inhibition with TNT005 rescues these effects.
ADVANCED THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Xiufang Guo, Virginia Smith, Max Jackson, My Tran, Michael Thomas, Aakash Patel, Eric Lorusso, Siddharth Nimbalkar, Yunqing Cai, Christopher W. McAleer, Ying Wang, Christopher J. Long, James J. Hickman
ADVANCED THERAPEUTICS
(2020)
Correction
Biochemical Research Methods
Ying I. Wang, Michael L. Shuler