Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

(2018) Johanna Pott et al.   Cell Host & Microbe

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

(2018) Yuxiao Sun et al.   CIRCULATION

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

(2018) Mohammad Samie et al.   NATURE IMMUNOLOGY

A Survey of Validation Strategies for CRISPR-Cas9 Editing

(2018) Monica F. Sentmanat et al.   Scientific Reports

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

(2018) Klaus Heger et al.   NATURE

SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Resting Memory CD4+ T Cells

(2018) Grant R. Campbell et al.   Cell Host & Microbe

S100A10 Regulates ULK1 Localization to ER–Mitochondria Contact Sites in IFN-γ-Triggered Autophagy

(2017) Ying-Da Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Association between genetic polymorphisms in the autophagy-related 5 gene promoter and the risk of sepsis

(2017) Yiming Shao et al.   Scientific Reports

Autophagy confers resistance to lipopolysaccharide-induced mouse hepatocyte injury

(2016) Gadi Lalazar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Identification of BECN1 and ATG14 Coiled-Coil Interface Residues That Are Important for Starvation-Induced Autophagy

(2016) Yang Mei et al.   BIOCHEMISTRY

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model

(2016) Song Chen et al.   GENES & DEVELOPMENT

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Autophagy is activated to protect against endotoxic acute kidney injury

(2016) Shuqin Mei et al.   Scientific Reports

ATG14 controls SNARE-mediated autophagosome fusion with a lysosome

(2015) Rong Liu et al.   Autophagy

Rubicon Deficiency Enhances Cardiac Autophagy and Protects Mice From Lipopolysaccharide-induced Lethality and Reduction in Stroke Volume

(2015) Zhenguo Zi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Critical Role for IL-18 in Spontaneous Lung Inflammation Caused by Autophagy Deficiency

(2015) Elmoataz Abdel Fattah et al.   JOURNAL OF IMMUNOLOGY

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

(2015) Jacqueline M. Kimmey et al.   NATURE

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners

(2014) Jun Hoe Kim et al.   Autophagy

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

The Two Faces of Receptor Interacting Protein Kinase-1

(2014) Ricardo Weinlich et al.   MOLECULAR CELL

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

(2014) Justine E. Roderick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation

(2013) M Amir et al.   CELL DEATH AND DIFFERENTIATION

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-  Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway

(2012) T. Matsuzawa et al.   JOURNAL OF IMMUNOLOGY

A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease

(2012) Branden Stansley et al.   Journal of Neuroinflammation

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

TNFα-Induced Necroptosis and Autophagy via Supression of the p38–NF-κB Survival Pathway in L929 Cells

(2011) Yuan-Chao Ye et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis

(2011) R. J. Thapa et al.   MOLECULAR AND CELLULAR BIOLOGY

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

Autophagy is a cell survival program for female germ cells in the murine ovary

(2011) Thomas R Gawriluk et al.   REPRODUCTION

Autophagic degradation of active caspase-8

(2010) Wen Hou et al.   Autophagy

Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation

(2010) M Won et al.   CELL DEATH AND DIFFERENTIATION

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

(2010) Kohichi Matsunaga et al.   JOURNAL OF CELL BIOLOGY

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Quaranfil, Johnston Atoll, and Lake Chad Viruses Are Novel Members of the Family Orthomyxoviridae

(2009) R. M. Presti et al.   JOURNAL OF VIROLOGY

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

(2008) B. D. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA