Progranulin deficiency leads to reduced glucocerebrosidase activity

The role of glucocerebrosidase in Parkinson disease pathogenesis

(2018) Matthew E. Gegg et al.   FEBS Journal

Genotype–phenotype links in frontotemporal lobar degeneration

(2018) Sara Van Mossevelde et al.   Nature Reviews Neurology

Evidence of Pre-Synaptic Dopaminergic Deficit in a Patient with a Novel Progranulin Mutation Presenting with Atypical Parkinsonism†

(2018) Miryam Carecchio et al.   JOURNAL OF ALZHEIMERS DISEASE

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

(2017) Clarissa Valdez et al.   HUMAN MOLECULAR GENETICS

The lysosomal protein cathepsin L is a progranulin protease

(2017) Chris W. Lee et al.   Molecular Neurodegeneration

Lysosomal processing of progranulin

(2017) Xiaolai Zhou et al.   Molecular Neurodegeneration

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

(2017) Xiaolai Zhou et al.   Nature Communications

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

(2017) Bret M. Evers et al.   Cell Reports

Portuguese family with the co-occurrence of frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis phenotypes due to progranulin gene mutation

(2016) Maria R. Almeida et al.   NEUROBIOLOGY OF AGING

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease

(2016) Jinlong Jian et al.   EBioMedicine

Association Between Progranulin and Gaucher Disease

(2016) Jinlong Jian et al.   EBioMedicine

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

(2015) Xiaolai Zhou et al.   JOURNAL OF CELL BIOLOGY

Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis

(2015) Yongdui Chen et al.   JOURNAL OF NEUROLOGY

The Evolution of the Secreted Regulatory Protein Progranulin

(2015) Roger G. E. Palfree et al.   PLoS One

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

(2015) Daniela Herrera Moro Chao et al.   PLoS One

Progranulin Gene Delivery Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

(2014) Jackalina M. Van Kampen et al.   PLoS One

Reduced serum progranulin level might be associated with Parkinson's disease risk

(2013) I. Mateo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population

(2013) Kuo-Hsuan Chang et al.   PLoS One

Expression of the Growth Factor Progranulin in Endothelial Cells Influences Growth and Development of Blood Vessels: A Novel Mouse Model

(2013) Huishi Toh et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage

(2012) Katherine R. Smith et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration

(2012) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of saposin C in Gaucher disease

(2012) Rafael J. Tamargo et al.   MOLECULAR GENETICS AND METABOLISM

Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

(2012) Y. Tanaka et al.   NEUROSCIENCE

Structure, Function, and Mechanism of Progranulin; the Brain and Beyond

(2011) Huishi Toh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function

(2011) Vincenzo Belcastro et al.   NUCLEIC ACIDS RESEARCH

Development and application of mass spectrometric methods for the analysis of progranulin N-glycosylation

(2010) Kriangsak Songsrirote et al.   Journal of Proteomics

Ultrasensitive in situ visualization of active glucocerebrosidase molecules

(2010) Martin D Witte et al.   Nature Chemical Biology

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease

(2008) Anne Rovelet-Lecrux et al.   NEUROBIOLOGY OF DISEASE

Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities

(2008) Dmitri Tolkatchev et al.   PROTEIN SCIENCE