Article
Gastroenterology & Hepatology
Yu A. An, Shiuhwei Chen, Yingfeng Deng, Zhao Wang, Jan-Bernd Funcke, Manasi Shah, Bo Shan, Ruth Gordillo, Jun Yoshino, Samuel Klein, Christine M. Kusminski, Philipp E. Scherer
Summary: The study highlights the essential role of mDIC in governing adipocyte lipolysis and preventing liver lipotoxicity in response to a high-fat diet. It is suggested that targeting the mDIC-succinate axis could be a potential treatment strategy for fatty liver disease.
JOURNAL OF HEPATOLOGY
(2021)
Review
Endocrinology & Metabolism
Irena Audzeyenka, Agnieszka Bierzynska, Abigail C. Lay
Summary: This review summarizes the current knowledge about podocyte mitochondrial dynamics in diabetic nephropathy, with a focus on bioenergetic pathways. It highlights key studies in this field and potential opportunities to enhance or protect podocyte mitochondrial function in the treatment of diabetic nephropathy.
Article
Medicine, Research & Experimental
Meiwen Ding, Evelyn Tolbert, Mark Birkenbach, Reginald Gohh, Fatemeh Akhlaghi, Nisanne S. Ghonem
Summary: Treprostinil significantly reduced peak elevated serum creatinine levels and accelerated normalization relative to IRI-placebo. Treatment with treprostinil inhibited IRI-mediated renal apoptosis, mitochondrial oxidative injury, and the release of cytochrome c versus IRI-placebo. Overall, treprostinil reduced mitochondrial-mediated renal apoptosis, inhibited mitochondria fission, and promoted mitochondria fusion, thereby accelerating mitochondrial recovery and protecting renal proximal tubules from renal IRI.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Fatemeh Yarmohammadi, A. Wallace Hayes, Gholamreza Karimi
Summary: Cardiac lipotoxicity is the harmful effects of excess lipid deposition in cardiomyocytes, resulting in changes in cardiac structure and function. Dysfunction in the heart is associated with abnormal lipid metabolism, potentially causing cardiomyocyte distress and subsequent contractile dysfunction. Various compounds have been researched for their protective effects against lipotoxicity progression in the heart, involving mechanisms such as improvement of calcium homeostasis, lipid metabolism, and mitochondrial dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Malak Alannan, Veronique Trezeguet, Nivea Dias Amoedo, Rodrigue Rossignol, Walid Mahfouf, Hamid Reza Rezvani, Franziska Dittrich-Domergue, Patrick Moreau, Sabrina Lacomme, Etienne Gontier, Christophe F. Grosset, Bassam Badran, Hussein Fayyad-Kazan, Aksam J. Merched
Summary: We investigated lipid metabolism abnormalities in liver cancer cells and found that targeting lipid addiction can be achieved with available drugs. Anti-PCSK9 treatment alone or in combination with statins can disrupt oncogenesis and potentially be repurposed for liver cancer treatment.
Article
Biochemistry & Molecular Biology
Aaron Afonso-Ali, Esteban Porrini, Silvia Teixido-Trujillo, Jose Antonio Perez-Perez, Sergio Luis-Lima, Nieves Guadalupe Acosta-Gonzalez, Irene Sosa-Paz, Laura Diaz-Martin, Covadonga Rodriguez-Gonzalez, Ana Elena Rodriguez-Rodriguez
Summary: The pathogenesis of obesity-related-renal disease is not clear, and the interaction between menopause and renal disease in obese women is still unknown. In this study, obese male and female mice developed albuminuria, hyperfiltration, and glomerulomegaly, and these changes were more severe in obese ovariectomized females. Obesity induced inflammation and an unbalanced lipidic profile in renal tissue, and this pattern seems to be enhanced in obesity after menopause.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Fei Tong, Jin Liu, Lei Luo, Lingyan Qiao, Jianming Wu, Guosheng Wu, Qibing Mei
Summary: An asymmetrical nanosystem consisting of gold nanoparticle-modified mesoporous silica, camouflaged with GYY4137 and decorated with l-serine and TK-SS31, was developed for the efficient treatment of acute kidney injury (AKI). The nanosystem showed progressive accumulation in renal sites due to enhanced permeability and retention (EPR) effect. It achieved pH-responsive hydrogen sulfide (H2S) and ROS-responsive SS31 release, resulting in active therapeutic effects mediated by nanomotor motion.
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Nan-Nan Liang, Ying Zhao, Yue-Yue Guo, Zhi-Hui Zhang, Lan Gao, De-Xin Yu, De-Xiang Xu, Shen Xu
Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Martin Ibanez, Luisa Fernanda Gonzalez Arbelaez, Alejandro Ciocci Pardo, Susana Mosca, Juan Manuel Lofeudo, Jorge Omar Velez Rueda, Ernesto Alejandro Aiello, Veronica Celeste De Giusti
Summary: In menopause, women face an increased risk of cardiovascular complications. This study explored the protective effects of GPER and its agonist G1 in OVX rats exposed to I/R, finding that chronic G1 treatment improved mitochondrial function and prevented mechanical alterations after injury. These findings suggest a potential therapeutic role for GPER modulation in cardiovascular health during menopause.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Food Science & Technology
Miguel-Angel Barrios-Maya, Angelica Ruiz-Ramirez, Hector Quezada, Carlos L. Cespedes Acuna, Mohammed El-Hafidi
Summary: The release of cytochrome c from liver mitochondria into the cytosol is a key process in hepatocyte apoptosis involved in the progression of non-alcoholic fatty liver disease (NAFLD) to more severe conditions. The study found that palmitoyl-CoA-induced cytochrome c release is sensitive to cyclosporine A, indicating the involvement of mitochondrial membrane permeability transition (mMPT). Despite increased H2O2 generation, cytochrome c release from sucrose-fed (SF) rat mitochondria remains significantly lower than normal mitochondria, possibly due to the enrichment of cardiolipin molecular species with palmitic acid.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Physiology
Tomas Luther, Sara Bulow-Anderberg, Patrik Persson, Stephanie Franzen, Paul Skorup, Annika Wernerson, Kjell Hultenby, Fredrik Palm, Tomas A. Schiffer, Robert Frithiof
Summary: In an ovine model of sepsis with acute kidney injury, renal mitochondrial dysfunction was demonstrated, characterized by a reduction in respiratory control ratio and an increased complex II/complex I ratio. However, no changes in mitochondrial efficiency or uncoupling were found, which could not explain the disturbed relation between renal oxygen consumption and Na thorn transport.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Lei Wang, Cheng Peng, Jianwen Chen, Huaikang Li, Qilong Jiao, Zhou Zhang, Li Wang, Qing Yuan, Baojun Wang, Yan Huang, Xin Ma
Summary: The study compares the effects of intermittent hilar occlusion (IHO) and continuous hilar occlusion (CHO) on kidney injury and oxidative damage. The results show that IHO can attenuate kidney injury, prolong tolerable ischemia duration, and prevent renal ischemia-reperfusion injury. Proper application of IHO can be extremely efficient in avoiding renal ischemia-reperfusion injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ion Alexandru Bobulescu, Laurentiu M. Pop, Chinnadurai Mani, Kala Turner, Christian Rivera, Sabiha Khatoon, Subash Kairamkonda, Raquibul Hannan, Komaraiah Palle
Summary: Clear cell renal cell carcinoma is the most common and deadly type of kidney cancer, characterized by large intracellular lipid deposits believed to result from lipid metabolic reprogramming in tumor cells. Obesity is an independent risk factor for this cancer, and may be linked to lipid accumulation and metabolic disturbances in noncancerous cells of the kidney.
Article
Pharmacology & Pharmacy
Yanqing Wang, Qian Liu, Jiaying Cai, Pin Wu, Di Wang, Yundi Shi, Tianru Huyan, Jing Su, Xuejun Li, Qi Wang, Hong Wang, Fengxue Zhang, Ok-Nam Bae, Lu Tie
Summary: Acute kidney injury (AKI) is a serious threat to human health, with ischemia-reperfusion (I/R) injury being one of the most common culprits. This study found that emodin, a natural compound, can improve AKI induced by I/R by protecting mitochondrial function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
