Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids

Vinyldiaminotriazine-acridine conjugate as G-quadruplex alkylating agent

(2018) Madoka E. Hazemi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide

(2018) Yueqin Zheng et al.   Nature Chemistry

Selective alkylation of T–T mismatched DNA using vinyldiaminotriazine–acridine conjugate

(2018) Kazumitsu Onizuka et al.   NUCLEIC ACIDS RESEARCH

Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA

(2018) Norihiro Sato et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

(2018) Raffaella Rossin et al.   Nature Communications

Furamidine Rescues Myotonic Dystrophy Type I Associated Mis-Splicing through Multiple Mechanisms

(2018) Jana R. Jenquin et al.   ACS Chemical Biology

Genetic regulation of the RUNX transcription factor family has antitumor effects

(2017) Ken Morita et al.   JOURNAL OF CLINICAL INVESTIGATION

Ruthenation of Non-stacked Guanines in DNA G-Quadruplex Structures: Enhancement ofc-MYCExpression

(2016) Jéssica Rodríguez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Linking of Antitumor trans NHC-Pt(II) Complexes to G-Quadruplex DNA Ligand for Telomeric Targeting

(2016) Jean-François Betzer et al.   BIOCONJUGATE CHEMISTRY

DNA cleavage at the AP site via β-elimination mediated by the AP site-binding ligands

(2016) Yukiko S. Abe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Precise small-molecule recognition of a toxic CUG RNA repeat expansion

(2016) Suzanne G Rzuczek et al.   Nature Chemical Biology

Design of a small molecule against an oncogenic noncoding RNA

(2016) Sai Pradeep Velagapudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new strategy for site-specific alkylation of DNA using oligonucleotides containing an abasic site and alkylating probes

(2015) Norihiro Sato et al.   CHEMICAL COMMUNICATIONS

Selective Alkylation of C-Rich Bulge Motifs in Nucleic Acids by Quinone Methide Derivatives

(2015) Tuomas Lönnberg et al.   CHEMISTRY-A EUROPEAN JOURNAL

Delineation of G-Quadruplex Alkylation Sites Mediated by 3,6-Bis(1-methyl-4-vinylpyridinium iodide)carbazole-Aniline Mustard Conjugates

(2015) Chien-Han Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA

(2015) Wang-Yong Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rationally Designed Small Molecules That Target Both the DNA and RNA Causing Myotonic Dystrophy Type 1

(2015) Lien Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models

(2015) Ruth B. Siboni et al.   Cell Reports

Small-molecule quadruplex-targeted drug discovery

(2014) Stephan A. Ohnmacht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Photoreactive G-Quadruplex Ligand Triggered by Green Light

(2014) Matteo Nadai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

(2014) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photo-Cross-Linking Probes for Trapping G-Quadruplex DNA

(2013) Daniela Verga et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Abasic site-binding ligands conjugated with cyanine dyes for “off–on” fluorescence sensing of orphan nucleobases in DNA duplexes and DNA–RNA hybrids

(2013) Yusuke Sato et al.   CHEMICAL COMMUNICATIONS

Strong and Selective Binding of Amiloride to an Abasic Site in RNA Duplexes: Thermodynamic Characterization and MicroRNA Detection

(2012) Yusuke Sato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Selective Catalytic Alkylation of DNA and RNA

(2012) Kiril Tishinov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site

(2012) Yukiko Abe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane

(2012) Filippo Doria et al.   CHEMISTRY-A EUROPEAN JOURNAL

The application of DNA and RNA G-quadruplexes to therapeutic medicines

(2011) Gavin W. Collie et al.   CHEMICAL SOCIETY REVIEWS

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

Repeat instability as the basis for human diseases and as a potential target for therapy

(2010) Arturo López Castel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

2-Aminopurine-Modified Abasic-Site-Containing Duplex DNA for Highly Selective Detection of Theophylline

(2009) Minjie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

(2009) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influence of substituent modifications on the binding of 2-amino-1,8-naphthyridines to cytosine opposite an AP site in DNA duplexes: thermodynamic characterization

(2009) Yusuke Sato et al.   NUCLEIC ACIDS RESEARCH