A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents

Vosaroxin induces mitochondrial dysfunction and apoptosis in cervical cancer HeLa cells: Involvement of AMPK/Sirt3/HIF-1 pathway

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Phase 3 results for vosaroxin/cytarabine in the subset of patients ≥60 years old with refractory/early relapsed acute myeloid leukemia

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Phase 3 results for vosaroxin/cytarabine in the subset of patients ≥60 years old with refractory/early relapsed acute myeloid leukemia

(2018) Farhad Ravandi et al.   HAEMATOLOGICA

When antibiotics turn toxic

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Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models

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ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

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Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes fromMycobacterium tuberculosis

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Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

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Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study

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Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86

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REVEAL-1, a phase 2 dose regimen optimization study of vosaroxin in older poor-risk patients with previously untreated acute myeloid leukaemia

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TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

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(2014) Liam S. Redgrave et al.   TRENDS IN MICROBIOLOGY

The role of DNA bending in type IIA topoisomerase function

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A national evaluation of antibiotic expenditures by healthcare setting in the United States, 2009

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The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

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Ciprofloxacin shows synergism with classical antifungals againstHistoplasma capsulatum var. capsulatumandCoccidioides posadasii

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NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity

(2012) Bryan H Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity

(2012) I. G. Cowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

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The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

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Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo

(2010) Caroline D. Scatena et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Three Decades of  -Lactamase Inhibitors

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

(2010) Michael C Haffner et al.   NATURE GENETICS

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

(2010) Alexandre Wohlkonig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

(2010) Rachael E. Hawtin et al.   PLoS One

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models

(2008) Ute Hoch et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Comparative pharmacodynamic interaction analysis between ciprofloxacin, moxifloxacin and levofloxacin and antifungal agents against Candida albicans and Aspergillus fumigatus

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Coupling between ATP Binding and DNA Cleavage by DNA Topoisomerase II

(2008) Felix Mueller-Planitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and Characterization of mAMSA-hypersensitive Mutants

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