The cell biology of asthma

The Epithelial Anion Transporter Pendrin Is Induced by Allergy and Rhinovirus Infection, Regulates Airway Surface Liquid, and Increases Airway Reactivity and Inflammation in an Asthma Model

(2014) Y. Nakagami et al.   JOURNAL OF IMMUNOLOGY

Th17-mediated inflammation in asthma

(2013) Dawn C Newcomb et al.   CURRENT OPINION IN IMMUNOLOGY

Periostin, a novel biomarker of TH2-driven asthma

(2013) Amit D. Parulekar et al.   CURRENT OPINION IN PULMONARY MEDICINE

Jagged1 is the major regulator of notch-dependent cell fate in proximal airways

(2013) Shubing Zhang et al.   DEVELOPMENTAL DYNAMICS

IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

(2013) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cells constitutively express arginase-I in the naïve and inflamed lung

(2013) Jennifer K. Bando et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Muc5b is required for airway defence

(2013) Michelle G. Roy et al.   NATURE

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

(2013) A. L. Garland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch Signaling Downregulates MUC5AC Expression in Airway Epithelial Cells through Hes1-Dependent Mechanisms

(2013) Hai-Feng Ou-Yang et al.   RESPIRATION

Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity

(2013) T. S. Worgall et al.   Science Translational Medicine

Airway Epithelial miRNA Expression Is Altered in Asthma

(2012) Owen D. Solberg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

AGR2 Is Induced in Asthma and Promotes Allergen-Induced Mucin Overproduction

(2012) Bradley W. Schroeder et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Influenza A Induces the Major Secreted Airway Mucin MUC5AC in a Protease–EGFR–Extracellular Regulated Kinase–Sp1–Dependent Pathway

(2012) Diane Barbier et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ciliated Cells of Pseudostratified Airway Epithelium Do Not Become Mucous Cells after Ovalbumin Challenge

(2012) Ana Pardo-Saganta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Type 2 innate lymphoid cells: new players in asthma and allergy

(2012) Seth T Scanlon et al.   CURRENT OPINION IN IMMUNOLOGY

Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin

(2012) Deepti R. Nagarkar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing

(2012) Chun Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-13–induced airway mucus production is attenuated by MAPK13 inhibition

(2012) Yael G. Alevy et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXM1 Promotes Allergen-Induced Goblet Cell Metaplasia and Pulmonary Inflammation

(2012) X. Ren et al.   MOLECULAR AND CELLULAR BIOLOGY

The ER stress transducer IRE1β is required for airway epithelial mucin production

(2012) M B Martino et al.   Mucosal Immunology

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia

(2012) T. R. Korfhagen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs

(2012) C. Ehre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction

(2012) M. Kudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

Lung damage and airway remodelling in severe asthma

(2011) C. E. Brightling et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development

(2011) Po-Nien Tsao et al.   DEVELOPMENT

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Muc5ac: a critical component mediating the rejection of enteric nematodes

(2011) Sumaira Z. Hasnain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

A new role for bicarbonate in mucus formation

(2010) Eric Y. T. Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma

(2010) Timothy D. Le Cras et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Asthma and Allergic Inflammation

(2010) Richard M. Locksley   CELL

Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma

(2010) Biju Thomas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

(2010) Umasundari Sivaprasad et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Foxa2 Programs Th2 Cell-Mediated Innate Immunity in the Developing Lung

(2010) G. Chen et al.   JOURNAL OF IMMUNOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

(2010) Steven A. Saenz et al.   NATURE

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of airway mucosal hydration

(2010) Derek Paisley et al.   Expert Review of Clinical Pharmacology

Interleukin-13–induced MUC5AC Is Regulated by 15-Lipoxygenase 1 Pathway in Human Bronchial Epithelial Cells

(2009) Jinming Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development

(2009) J. S. Guseh et al.   DEVELOPMENT

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

Synaptotagmin 2 Couples Mucin Granule Exocytosis to Ca2+Signaling from Endoplasmic Reticulum

(2009) Michael J. Tuvim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

(2009) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor Necrosis Factor–α (TNF-α) Induces Upregulation of RhoA via NF-κB Activation in Cultured Human Bronchial Smooth Muscle Cells

(2009) Kumiko Goto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

(2009) S.-W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium

(2008) Jonathan L. Koff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ORMDL3Gene Is Associated with Asthma in Three Ethnically Diverse Populations

(2008) Joshua Galanter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-13 Augments Bronchial Smooth Muscle Contractility with an Up-Regulation of RhoA Protein

(2008) Yoshihiko Chiba et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway

(2008) Lingxiang Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Munc13-2−/−baseline secretion defect reveals source of oligomeric mucins in mouse airways

(2008) Yunxiang Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE