Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms

Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Δ9-Tetrahydrocannabinol-Induced Cognitive Impairment

(2019) Ester Aso et al.   MOLECULAR NEUROBIOLOGY

Tempering aversive/traumatic memories with cannabinoids: a review of evidence from animal and human studies

(2019) Sabrina F. Lisboa et al.   PSYCHOPHARMACOLOGY

Cannabinoid Ligands Targeting TRP Channels

(2019) Chanté Muller et al.   Frontiers in Molecular Neuroscience

Cannabidiol as a Novel Candidate Alcohol Use Disorder Pharmacotherapy: A Systematic Review

(2019) Jasmine Turna et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cannabidiol modulates the expression of neuroinflammatory factors in stress- and drug-induced reinstatement of methamphetamine in extinguished rats

(2019) Saeideh Karimi-Haghighi et al.   ADDICTION BIOLOGY

Medications to treat cocaine use disorders

(2019) Jonathan Buchholz et al.   CURRENT OPINION IN PSYCHIATRY

The Endocannabinoid System and Cannabidiol's Promise for the Treatment of Substance Use Disorder

(2019) Yann Chye et al.   Frontiers in Psychiatry

Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System

(2018) Shana M. Augustin et al.   ACS Chemical Neuroscience

GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol

(2018) Alyssa S. Laun et al.   ACTA PHARMACOLOGICA SINICA

Cannabidiol does not display drug abuse potential in mice behavior

(2018) Adrián Viudez-Martínez et al.   ACTA PHARMACOLOGICA SINICA

Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking

(2018) Kyle T. Brown et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of cannabidiol plus naltrexone on motivation and ethanol consumption

(2018) Adrián Viudez-Martínez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors

(2018) Mylyne Tham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test

(2018) Ariandra G Sartim et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

(2018) Amanda J. Sales et al.   MOLECULAR NEUROBIOLOGY

Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons

(2018) Alex Straiker et al.   MOLECULAR PHARMACOLOGY

Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle

(2018) Gustavo Gonzalez-Cuevas et al.   NEUROPSYCHOPHARMACOLOGY

Effects of Cannabinoid Drugs on Aversive or Rewarding Drug-Associated Memory Extinction and Reconsolidation

(2018) Cristina A.J. Stern et al.   NEUROSCIENCE

Cannabidiol inhibits priming-induced reinstatement of methamphetamine in REM sleep deprived rats

(2018) Saeideh Karimi-Haghighi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels

(2018) Amanda J. Sales et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Do psychoactive drugs have a therapeutic role in compulsivity? Studies on schedule-induced polydipsia

(2018) Elena Martín-González et al.   PSYCHOPHARMACOLOGY

Cannabidiol effects on prepulse inhibition in nonhuman primates

(2018) Patricia G. Saletti et al.   REVIEWS IN THE NEUROSCIENCES

The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers

(2018) C. Hindocha et al.   Scientific Reports

Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview

(2018) G. M. Mandolini et al.   Epidemiology and Psychiatric Sciences

Cannabidiol treatment reduces the motivation to self-administer methamphetamine and methamphetamine-primed relapse in rats

(2018) Gracie L Hay et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus

(2018) Miguel Ángel Luján et al.   NEUROPHARMACOLOGY

Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials

(2018) Rafael M. Bitencourt et al.   Frontiers in Neuroscience

Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

(2018) José A. Crippa et al.   Frontiers in Immunology

Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice

(2018) Rocio Saravia et al.   BRAIN BEHAVIOR AND IMMUNITY

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

(2018) Lesley Taylor et al.   CNS DRUGS

Methamphetamine use and cognitive function: A systematic review of neuroimaging research

(2018) Sabrini Sabrini et al.   DRUG AND ALCOHOL DEPENDENCE

Natural Negative Allosteric Modulators of 5-HT3 Receptors

(2018) Lina T. Al Kury et al.   MOLECULES

Effects of cannabidiol in males and females in two different rat models of depression

(2018) Liat Shbiro et al.   PHYSIOLOGY & BEHAVIOR

Pharmacotherapeutic agents in the treatment of methamphetamine dependence

(2017) Kirsten C. Morley et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid

(2017) Ewa Kozela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments

(2017) Justine Renard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cannabidiol: State of the art and new challenges for therapeutic applications

(2017) Simona Pisanti et al.   PHARMACOLOGY & THERAPEUTICS

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence

(2017) Peter D Alexander et al.   PSYCHOPHARMACOLOGY

Phytocannabinoids modulate emotional memory processing through interactions with the ventral hippocampus and mesolimbic dopamine system: implications for neuropsychiatric pathology

(2017) Roger Hudson et al.   PSYCHOPHARMACOLOGY

Cannabidiol: Swinging the Marijuana Pendulum From ‘Weed’ to Medication to Treat the Opioid Epidemic

(2017) Yasmin L. Hurd   TRENDS IN NEUROSCIENCES

Cannabidiol disrupts the reconsolidation of contextual drug-associated memories in Wistar rats

(2016) Cristiane Ribeiro de Carvalho et al.   ADDICTION BIOLOGY

Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?

(2016) Natalie E. Zlebnik et al.   Annual Review of Neuroscience

Antidepressant-like effect of cannabidiol injection into the ventral medial prefrontal cortex—Possible involvement of 5-HT1A and CB1 receptors

(2016) A.G. Sartim et al.   BEHAVIOURAL BRAIN RESEARCH

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

Advances and challenges in pharmacotherapeutics for amphetamine-type stimulants addiction

(2016) Dan-Ni Cao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway

(2016) Justine Renard et al.   JOURNAL OF NEUROSCIENCE

Effects of an acute cannabidiol treatment on cocaine self-administration and cue-induced cocaine seeking in male rats

(2016) Ashraf Mahmud et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors

(2016) Raquel Linge et al.   NEUROPHARMACOLOGY

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

(2016) Angélica Pupin Schiavon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose

(2016) P Seeman   Translational Psychiatry

Bidirectional Effects of Cannabidiol on Contextual Fear Memory Extinction

(2016) Chenchen Song et al.   Frontiers in Pharmacology

Cannabidiol as a Potential New Type of an Antipsychotic. A Critical Review of the Evidence

(2016) Cathrin Rohleder et al.   Frontiers in Pharmacology

Cannabidiol Regulation of Learned Fear: Implications for Treating Anxiety-Related Disorders

(2016) Regimantas Jurkus et al.   Frontiers in Pharmacology

The role of serotonin in drug use and addiction

(2015) Christian P. Müller et al.   BEHAVIOURAL BRAIN RESEARCH

Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

(2015) John M McPartland et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

(2015) R B Laprairie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

(2015) Luciano Rezende Vilela et al.   MEDIATORS OF INFLAMMATION

Cannabidiol as a Potential Treatment for Anxiety Disorders

(2015) Esther M. Blessing et al.   Neurotherapeutics

Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release

(2015) Pedro H. Gobira et al.   NEUROTOXICOLOGY

Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine

(2015) J. F. C. Pedrazzi et al.   PSYCHOPHARMACOLOGY

Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol

(2015) Felipe V. Gomes et al.   SCHIZOPHRENIA RESEARCH

PTSD-Like Memory Generated Through Enhanced Noradrenergic Activity is Mitigated by a Dual Step Pharmacological Intervention Targeting its Reconsolidation

(2015) L. Gazarini et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa

(2014) Alexandre Schier et al.   CNS & Neurological Disorders-Drug Targets

Cocaine and Cognition

(2014) Stéphane Potvin et al.   Journal of Addiction Medicine

Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats

(2014) Stephanie Mijangos-Moreno et al.   NEUROSCIENCE RESEARCH

Efficacy of buspirone for attenuating cocaine and methamphetamine reinstatement in rats

(2013) Keith L. Shelton et al.   DRUG AND ALCOHOL DEPENDENCE

Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors

(2013) Mohamed Mahgoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

(2013) Alline C. Campos et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1Areceptors in the dorsal raphe nucleus

(2012) Vicky Katsidoni et al.   ADDICTION BIOLOGY

The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats

(2012) Przemysław Adamczyk et al.   BRAIN RESEARCH

The orphan receptor GPR3 modulates the early phases of cocaine reinforcement

(2012) Clara Tourino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Drink, drugs and disruption: memory manipulation for the treatment of addiction

(2012) AL Milton   CURRENT OPINION IN NEUROBIOLOGY

On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment

(2012) Cristina A J Stern et al.   NEUROPSYCHOPHARMACOLOGY

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

(2012) A. C. Campos et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

(2012) F M Leweke et al.   Translational Psychiatry

Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala.

(2011) Gislaine Z. Réus et al.   ACTA NEUROPSYCHIATRICA

Induction of innate immune genes in brain create the neurobiology of addiction

(2011) F.T. Crews et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats

(2011) Eric Murillo-Rodríguez et al.   LIFE SCIENCES

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour

(2011) Serena Deiana et al.   PSYCHOPHARMACOLOGY

Attenuation of reinforcing and psychomotor stimulant effects of amphetamine by aripiprazole

(2010) Pia Bäckström et al.   ADDICTION BIOLOGY

The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes

(2010) K. H. Yang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist

(2010) M. Picard et al.   NEUROSCIENCE

Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

(2010) Abir T. El-Alfy et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

(2009) TV Zanelati et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for modulation of inflammatory disease

(2009) S.E. O'Sullivan et al.   IMMUNOBIOLOGY

Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances

(2009) Y. Ren et al.   JOURNAL OF NEUROSCIENCE

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania

(2009) Samira S Valvassori et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology

(2009) Sagnik Bhattacharyya et al.   NEUROPSYCHOPHARMACOLOGY

The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function

(2009) Jörg Ahrens et al.   PHARMACOLOGY

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

(2009) L. S. Whyte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapse

(2009) Matthew W. Feltenstein et al.   PSYCHOPHARMACOLOGY

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

(2009) Angelo A. Izzo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

(2008) N. Qin et al.   JOURNAL OF NEUROSCIENCE

Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice

(2008) Gunnar Sørensen et al.   PSYCHOPHARMACOLOGY

Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats

(2008) Alline Cristina Campos et al.   PSYCHOPHARMACOLOGY

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

(2007) A Thomas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid pharmacology: the first 66 years

(2006) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY