Anticancer Function and ROS-Mediated Multi-Targeting Anticancer Mechanisms of Copper (II) 2-hydroxy-1-naphthaldehyde Complexes

P44/42 MAPK signal pathway-mediated hyperphosphorylation of paxillin and redistribution of E-cadherin was involved in microcystin-LR-reduced cellular adhesion in a human liver cell line

(2018) Yu Sun et al.   CHEMOSPHERE

Dual or multi-targeting inhibitors: The next generation anticancer agents

(2018) Nulgumnalli Manjunathaiah Raghavendra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure and biological properties of five Pt(II) complexes as potential anticancer agents

(2018) Jungang Deng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

In vitro cytotoxic activity of a novel Schiff base ligand derived from 2-hydroxy-1-naphthaldehyde and its mononuclear metal complexes

(2018) Zeinab Abbasi et al.   JOURNAL OF MOLECULAR STRUCTURE

Piperidylthiosemicarbazones Cu(II) complexes with a high anticancer activity by catalyzing hydrogen peroxide to degrade DNA and promote apoptosis

(2018) Jinxu Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel Schiff base derived from the gabapentin drug and copper (II) complex: Synthesis, characterization, interaction with DNA/protein and cytotoxic activity

(2016) Zahra Shokohi-pour et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

Unprecedented formation of organo-ruthenium(ii) complexes containing 2-hydroxy-1-naphthaldehyde S-benzyldithiocarbazate: synthesis, X-ray crystal structure, DFT study and their biological activities in vitro

(2015) Paranthaman Vijayan et al.   Inorganic Chemistry Frontiers

Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy

(2014) Sungwoo Park et al.   Autophagy

Targeting DNA repair pathways for cancer treatment: what’s new?

(2014) Mark R Kelley et al.   Future Oncology

Selective anticancer copper(ii)-mixed ligand complexes: targeting of ROS and proteasomes

(2014) Chew Hee Ng et al.   Metallomics

Effect of cooperative non-covalent interactions on the solid state heterochiral self-assembly: The concepts of isotactic and syndiotactic arrangements in coordination complex

(2013) Himanshu Sekhar Jena   INORGANICA CHIMICA ACTA

Multi-targeted organometallic ruthenium(II)–arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: A strategy to improve cytotoxicity

(2013) Zhigang Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

2-Hydroxynaphthalene-1-carbaldehyde- and 2-(Aminomethyl)pyridine-BasedSchiffBase CuIIComplexes for DNA Binding and Cleavage

(2012) Pulimamidi Rabindra Reddy et al.   CHEMISTRY & BIODIVERSITY

Di- and tri-organotin(IV) complexes with 2-hydroxy-1-naphthaldehyde 5-chloro-2-hydroxybenzoylhydrazone: Synthesis, characterization and in vitro antitumor activities

(2012) Min Hong et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species

(2012) FAN HE et al.   ONCOLOGY REPORTS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Transition Metal Based Anticancer Drugs

(2011) K. Benjamin Garbutcheon-Singh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)

(2011) Xiaobing Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

(2011) Christian R. Kowol et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cellular copper distribution: a mechanistic systems biology approach

(2010) Lucia Banci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model

(2010) N. Raman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Overcoming cisplatin resistance of ovarian cancer cells by targeted liposomes in vitro

(2010) Michaela L. Krieger et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

The roles of ASK family proteins in stress responses and diseases

(2009) Kazuki Hattori et al.   Cell Communication and Signaling

Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)–2,2′-bipyridyl mixed ligand copper(ii) complexes

(2009) Andrei S. Potapov et al.   DALTON TRANSACTIONS

ROS-mediated autophagy was involved in cancer cell death induced by novel copper(II) complex

(2009) Wen-jie Guo et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

OLEX2: a complete structure solution, refinement and analysis program

(2009) Oleg V. Dolomanov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Early effects of copper accumulation on methionine metabolism

(2008) M. Delgado et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage

(2008) S. Giordano et al.   CURRENT MEDICINAL CHEMISTRY

Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway

(2008) W. Wei-Lynn Wong et al.   IUBMB LIFE

CDK inhibitors in cancer therapy: what is next?

(2007) Marcos Malumbres et al.   TRENDS IN PHARMACOLOGICAL SCIENCES