Apelin promotes hepatic fibrosis through ERK signaling in LX-2 cells

Osteopontin promotes collagen I synthesis in hepatic stellate cells by miRNA-129-5p inhibition

(2018) Yinghua Chen et al.   EXPERIMENTAL CELL RESEARCH

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects

(2017) Romain Gerbier et al.   FASEB JOURNAL

Apelin Is a Negative Regulator of Angiotensin II–Mediated Adverse Myocardial Remodeling and DysfunctionNovelty and Significance

(2017) Zhen-Zhou Zhang et al.   HYPERTENSION

Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure

(2017) Benjamin L. Woolbright et al.   JOURNAL OF HEPATOLOGY

A diet-induced Sprague–Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis

(2017) Mayuko Ichimura et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC

(2017) Farzaneh Rostamzadeh et al.   LIFE SCIENCES

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

The Role of the Apelin/APJ System in the Regulation of Liver Disease

(2017) Xinrui Lv et al.   Frontiers in Pharmacology

Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis

(2017) Cristina Baciu et al.   PLoS One

Apelin: A novel inhibitor of vascular calcification in chronic kidney disease

(2016) Xue Han et al.   ATHEROSCLEROSIS

Clinical Implications of the Serum Apelin Level on Portal Hypertension and Prognosis of Liver Cirrhosis

(2016) Yoo Li Lim et al.   Gut and Liver

Relevance of activated hepatic stellate cells in predicting the development of pediatric liver allograft fibrosis

(2016) Carla Venturi et al.   LIVER TRANSPLANTATION

Apelin/APJ system as a therapeutic target in diabetes and its complications

(2016) Haoliang Hu et al.   MOLECULAR GENETICS AND METABOLISM

Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke

(2016) Yi Yang et al.   PEPTIDES

Apelin receptors: From signaling to antidiabetic strategy

(2015) C. Chaves-Almagro et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apelin and energy metabolism

(2015) Chantal Bertrand et al.   Frontiers in Physiology

Hypothalamic Apelin/Reactive Oxygen Species Signaling Controls Hepatic Glucose Metabolism in the Onset of Diabetes

(2013) Anne Drougard et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells

(2013) Xin-rui Lv et al.   BIOCHEMICAL JOURNAL

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ

(2013) Jiaojiao Chu et al.   PLoS One

Pathogenesis of Liver Injury in Acute Liver Failure

(2012) Raymond T. Chung et al.   GASTROENTEROLOGY

Involvement of the apelin receptor APJ in Fas-induced liver injury

(2012) Hiroaki Yasuzaki et al.   LIVER INTERNATIONAL

HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs

(2011) Bin Zheng et al.   CELL RESEARCH

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Apelin Mediates the Induction of Profibrogenic Genes in Human Hepatic Stellate Cells

(2010) Pedro Melgar-Lesmes et al.   ENDOCRINOLOGY

Overexpression of apelin receptor (APJ/AGTRL1) on hepatic stellate cells and sinusoidal angiogenesis in human cirrhotic liver

(2010) Hiroaki Yokomori et al.   JOURNAL OF GASTROENTEROLOGY

Plasma apelin levels in subjects with nonalcoholic fatty liver disease

(2010) Cemal Nuri Ercin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

G Protein-Coupled Receptor APJ and Its Ligand Apelin Act Downstream of Cripto to Specify Embryonic Stem Cells Toward the Cardiac Lineage Through Extracellular Signal-Regulated Kinase/p70S6 Kinase Signaling Pathway

(2009) Cristina D'Aniello et al.   CIRCULATION RESEARCH

The hepatic apelin system: A new therapeutic target for liver disease

(2008) Alessandro Principe et al.   HEPATOLOGY