MALDI-MS of drugs: Profiling, imaging, and steps towards quantitative analysis

Mass Spectrometry Imaging in Drug Development

(2015) Anna Nilsson et al.   ANALYTICAL CHEMISTRY

Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS

(2015) Jeremy A. Barry et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling

(2015) Boone M. Prentice et al.   JOURNAL OF MASS SPECTROMETRY

Application of chemometric algorithms to MALDI mass spectrometry imaging of pharmaceutical tablets

(2015) Yoann Gut et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Use of Mass Spectrometry Imaging to Predict Treatment Response of Patient-Derived Xenograft Models of Triple-Negative Breast Cancer

(2015) Nadine E. Mascini et al.   JOURNAL OF PROTEOME RESEARCH

MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice

(2015) Michaela Aichler et al.   LABORATORY INVESTIGATION

MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics

(2015) Ekta Patel et al.   Bioanalysis

In situ assessment of atorvastatin impurity using MALDI mass spectrometry imaging (MALDI-MSI)

(2014) Lívia Riberti Rodrigues et al.   ANALYTICA CHIMICA ACTA

Distribution study of atorvastatin and its metabolites in rat tissues using combined information from UHPLC/MS and MALDI-Orbitrap-MS imaging

(2014) Robert Jirásko et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Standardized processing of MALDI imaging raw data for enhancement of weak analyte signals in mouse models of gastric cancer and Alzheimer’s disease

(2014) Matthias Schwartz et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mass imaging of ketamine in a single scalp hair by MALDI-FTMS

(2014) Min Shen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization

(2014) Mark T. Bokhart et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Single Hair Analysis of Small Molecules Using MALDI-Triple Quadrupole MS Imaging and LC-MS/MS: Investigations on Opportunities and Pitfalls

(2014) Michael Poetzsch et al.   ANALYTICAL CHEMISTRY

Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis

(2014) John G. Swales et al.   ANALYTICAL CHEMISTRY

Novel Approach of MALDI Drug Imaging, Immunohistochemistry, and Digital Image Analysis for Drug Distribution Studies in Tissues

(2014) Katharina Huber et al.   ANALYTICAL CHEMISTRY

Segmental hair analysis for differentiation of tilidine intake from external contamination using LC-ESI-MS/MS and MALDI-MS/MS imaging

(2014) Michael Poetzsch et al.   Drug Testing and Analysis

Single-hair analysis of zolpidem on the supposition of its single administration in drug-facilitated crimes

(2014) Noriaki Shima et al.   Forensic Toxicology

A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies

(2014) K. Huber et al.   HISTOCHEMISTRY AND CELL BIOLOGY

In Situ Label-Free Visualization of Orally Dosed Strictinin within Mouse Kidney by MALDI-MS Imaging

(2014) Yoon Hee Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quantitative Mass Barcode-Like Image of Nicotine in Single Longitudinally Sliced Hair Sections from Long-Term Smokers by Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry Imaging

(2014) Toyofumi Nakanishi et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

The Use of Random Projections for the Analysis of Mass Spectrometry Imaging Data

(2014) Andrew D. Palmer et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A new look at drugs targeting malignant melanoma-An application for mass spectrometry imaging

(2014) Yutaka Sugihara et al.   PROTEOMICS

Using a single, high mass resolution mass spectrometry platform to investigate ion suppression effects observed during tissue imaging

(2014) Laura Tomlinson et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Quantitative whole-body autoradiography, LC–MS/MS and MALDI for drug-distribution studies in biological samples: the ultimate matrix trilogy

(2014) Andrew B McEwen et al.   Bioanalysis

Imaging mass spectrometry: From tissue sections to cell cultures

(2013) Eric M. Weaver et al.   ADVANCED DRUG DELIVERY REVIEWS

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites

(2013) Christopher B. Lietz et al.   ADVANCED DRUG DELIVERY REVIEWS

DMSO-enhanced MALDI MS imaging with normalization against a deuterated standard for relative quantification of dasatinib in serial mouse pharmacology studies

(2013) Sandra Schulz et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Memory Efficient Principal Component Analysis for the Dimensionality Reduction of Large Mass Spectrometry Imaging Data Sets

(2013) Alan M. Race et al.   ANALYTICAL CHEMISTRY

Curcumin: A Multipurpose Matrix for MALDI Mass Spectrometry Imaging Applications

(2013) S. Francese et al.   ANALYTICAL CHEMISTRY

Evaluation of Therapeutics in Three-Dimensional Cell Culture Systems by MALDI Imaging Mass Spectrometry

(2013) Xin Liu et al.   ANALYTICAL CHEMISTRY

A Mimetic Tissue Model for the Quantification of Drug Distributions by MALDI Imaging Mass Spectrometry

(2013) M. Reid Groseclose et al.   ANALYTICAL CHEMISTRY

Determination of cucumarioside A2-2 in mouse spleen by radiospectroscopy, MALDI-MS and MALDI-IMS

(2013) E.A. Pislyagin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mass spectrometry imaging with high resolution in mass and space

(2013) Andreas Römpp et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels

(2013) Na Sun et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Experimental Models to Study Drug Distributions in Tissue Using MALDI Mass Spectrometry Imaging

(2013) Ákos Végvári et al.   JOURNAL OF PROTEOME RESEARCH

para-Nitroaniline is a Promising Matrix for MALDI-MS Imaging on Intermediate Pressure MS Systems

(2013) Rory T. Steven et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Quantitative imaging of a therapeutic peptide in biological tissue sections by MALDI MS

(2013) Nozomi Takai et al.   Bioanalysis

A new combination MALDI matrix for small molecule analysis: application to imaging mass spectrometry for drugs and metabolites

(2012) Selina Rahman Shanta et al.   ANALYST

Distribution measurements of 3,4-methylenedioxymethamphetamine and its metabolites in organs by matrix-assisted laser desorption/ionization imaging mass spectrometry using an automatic matrix spraying system with an air brush and a turntable

(2012) Kenji Kuwayama et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Identifying Tissue-Specific Signal Variation in MALDI Mass Spectrometric Imaging by Use of an Internal Standard

(2012) David A. Pirman et al.   ANALYTICAL CHEMISTRY

Quantitative MALDI Tandem Mass Spectrometric Imaging of Cocaine from Brain Tissue with a Deuterated Internal Standard

(2012) David A. Pirman et al.   ANALYTICAL CHEMISTRY

Hyperspectral Visualization of Mass Spectrometry Imaging Data

(2012) Judith M. Fonville et al.   ANALYTICAL CHEMISTRY

Central Nervous System Disposition and Metabolism of Fosdevirine (GSK2248761), a Non-Nucleoside Reverse Transcriptase Inhibitor: An LC-MS and Matrix-Assisted Laser Desorption/Ionization Imaging MS Investigation into Central Nervous System Toxicity

(2012) Stephen Castellino et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A vision for better health: Mass spectrometry imaging for clinical diagnostics

(2012) Hui Ye et al.   CLINICA CHIMICA ACTA

Imaging mass spectrometry statistical analysis

(2012) Emrys A. Jones et al.   Journal of Proteomics

Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor

(2012) Gregory Hamm et al.   Journal of Proteomics

Novel mass spectrometry imaging software assisting labeled normalization and quantitation of drugs and neuropeptides directly in tissue sections

(2012) Patrik Källback et al.   Journal of Proteomics

Inclusive sharing of mass spectrometry imaging data requires a converter for all

(2012) Alan M. Race et al.   Journal of Proteomics

Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry

(2012) Nozomi Takai et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution

(2011) Christopher D. Cerruti et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions

(2011) Brendan Prideaux et al.   ANALYTICAL CHEMISTRY

Distribution of chloroquine in ocular tissue of pigmented rat using matrix-assisted laser desorption/ionization imaging quadrupole time-of-flight tandem mass spectrometry

(2011) Yasuhiro Yamada et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A quantitation method for mass spectrometry imaging

(2011) Stormy L. Koeniger et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients

(2010) Roland J. W. Meesters et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Direct Standard-Free Quantitation of Tamiflu and Other Pharmaceutical Tablets Using Clustering Agents with Electrospray Ionization Mass Spectrometry

(2010) Tawnya G. Flick et al.   ANALYTICAL CHEMISTRY

Use of a Solvent-Free Dry Matrix Coating for Quantitative Matrix-Assisted Laser Desorption Ionization Imaging of 4-Bromophenyl-1,4-diazabicyclo(3.2.2)nonane-4-carboxylate in Rat Brain and Quantitative Analysis of the Drug from Laser Microdissected Tissue Regions

(2010) R. J. A. Goodwin et al.   ANALYTICAL CHEMISTRY

Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry

(2010) Anna Nilsson et al.   PLoS One

Direct analysis of pharmaceutical tablet formulations using matrix-assisted laser desorption/ionisation mass spectrometry imaging

(2010) Caroline J. Earnshaw et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Evaluation and performance of desorption electrospray ionization using a triple quadrupole mass spectrometer for quantitation of pharmaceuticals in plasma

(2010) Joseph H. Kennedy et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Mass spectrometry imaging of pharmacological compounds in tissue sections

(2010) Richard JA Goodwin et al.   Bioanalysis

Comparison between vacuum sublimed matrices and conventional dried droplet preparation in MALDI-TOF mass spectrometry

(2009) Thorsten W. Jaskolla et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Rapid simultaneous quantitative determination of different small pharmaceutical drugs using a conventional matrix-assisted laser desorption/ionization time-of-flight mass spectrometry system

(2009) Markus Persike et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Matrix-assisted laser desorption/ionization mass spectrometric imaging of complete rat sections using a triple quadrupole linear ion trap

(2009) Gérard Hopfgartner et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Quantitative Analysis of Antiretroviral Drugs in Lysates of Peripheral Blood Mononuclear Cells Using MALDI-Triple Quadrupole Mass Spectrometry

(2008) Jeroen J. A. van Kampen et al.   ANALYTICAL CHEMISTRY

Matrix-Assisted Laser Desorption/Ionization-Ion Mobility Separation-Mass Spectrometry Imaging of Vinblastine in Whole Body Tissue Sections

(2008) Paul J. Trim et al.   ANALYTICAL CHEMISTRY

Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF

(2008) Stefania Notari et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Direct profiling of tissue lipids by MALDI-TOFMS

(2008) Shelley N. Jackson et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections

(2008) Erin H. Seeley et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY