Animal models of colorectal cancer

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Microsatellite Instability and Colorectal Cancer

(2011) Katherine B. Geiersbach et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

TGF-beta signalling in colon carcinogenesis

(2011) Pavlos Lampropoulos et al.   CANCER LETTERS

New perspectives on APC control of cell fate and proliferation in colorectal cancer

(2011) Reid A. Phelps et al.   CELL CYCLE

Dietary patterns and colorectal cancer

(2011) Bruno Magalhães et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Mutant Kras Promotes Hyperplasia and Alters Differentiation in the Colon Epithelium but Does Not Expand the Presumptive Stem Cell Pool

(2011) Ying Feng et al.   GASTROENTEROLOGY

GATA Factors Regulate Proliferation, Differentiation, and Gene Expression in Small Intestine of Mature Mice

(2011) Eva Beuling et al.   GASTROENTEROLOGY

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The C-terminus of Apc does not influence intestinal adenoma development or progression

(2011) Annabelle Lewis et al.   JOURNAL OF PATHOLOGY

DCC constrains tumour progression via its dependence receptor activity

(2011) Marie Castets et al.   NATURE

A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression

(2011) M Zeineldin et al.   ONCOGENE

A new conditional Apc-mutant mouse model for colorectal cancer

(2010) E. C. Robanus-Maandag et al.   CARCINOGENESIS

Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer

(2010) Anna Isinger-Ekstrand et al.   Familial Cancer

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

(2010) Nick Barker et al.   GASTROENTEROLOGY

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

The NSAID sulindac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon

(2010) D. Mladenova et al.   GUT

Morphological and Molecular Alterations in 1,2 Dimethylhydrazine and Azoxymethane Induced Colon Carcinogenesis in Rats

(2010) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Alterations in calcium intake on peak bone mass in the female rat

(2010) Catherine A. Peterson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability

(2010) Feijun Luo et al.   JOURNAL OF PATHOLOGY

Generation of a Transgenic Mouse for Colorectal Cancer Research with Intestinal Cre Expression Limited to the Large Intestine

(2010) Y. Xue et al.   MOLECULAR CANCER RESEARCH

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

(2010) K. E. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colorectal cancer incidence in the United States, 1999-2004

(2009) Sun Hee Rim et al.   CANCER

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

(2009) Patrick Pollard et al.   GASTROENTEROLOGY

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway

(2009) Patty Trobridge et al.   GASTROENTEROLOGY

An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents

(2009) Melanie H. Kucherlapati et al.   GASTROENTEROLOGY

DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome

(2009) George Poulogiannis et al.   HISTOPATHOLOGY

Mutated K-rasAsp12promotes tumourigenesis inApcMinmice more in the large than the small intestines, with synergistic effects between K-rasandWntpathways

(2009) Feijun Luo et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

(2009) Pierre Laurent-Puig et al.   JOURNAL OF CLINICAL ONCOLOGY

A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

(2009) T. K. Starr et al.   SCIENCE

A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis

(2009) Claudia Gaspar et al.   PLoS Genetics

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine

(2008) Karen R Reed et al.   BMC CANCER

Dietary Induction of Colonic Tumors in a Mouse Model of Sporadic Colon Cancer

(2008) K. Yang et al.   CANCER RESEARCH

Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation

(2008) K. Yang et al.   CANCER RESEARCH

Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer

(2008) H. L. Newmark et al.   CARCINOGENESIS

The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival

(2008) Y A Valentin-Vega et al.   CELL DEATH AND DIFFERENTIATION

A CK19CreERTknockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs

(2008) Anna L. Means et al.   GENESIS

OncogenicK-ras promotes early carcinogenesis in the mouse proximal colon

(2008) Shelly R. Calcagno et al.   INTERNATIONAL JOURNAL OF CANCER

The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model:wild-type andp53+/– mice

(2008) Ying Hu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

(2008) Victoria Marsh et al.   NATURE GENETICS

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS

Generating somatic mosaicism with a Cre recombinase–microsatellite sequence transgene

(2008) Aytekin Akyol et al.   NATURE METHODS

Apc mice: Models, modifiers and mutants

(2008) Amy E. McCart et al.   PATHOLOGY RESEARCH AND PRACTICE

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

(2008) R. J. Leary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression

(2008) Peng-Chieh Chen et al.   PLoS Genetics