SOD1 in amyotrophic lateral sclerosis development – in silico analysis and molecular dynamics of A4F and A4V variants

A theoretical study on Zn binding loop mutants instigating destabilization and metal binding loss in human SOD1 protein

(2017) E. Srinivasan et al.   JOURNAL OF MOLECULAR MODELING

A profound computational study to prioritize the disease-causing mutations in PRPS1 gene

(2017) Ashish Kumar Agrahari et al.   METABOLIC BRAIN DISEASE

Exploring the cause of aggregation and reduced Zn binding affinity by G85R mutation in SOD1 rendering amyotrophic lateral sclerosis

(2017) E. Srinivasan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

CheckMyMetal: a macromolecular metal-binding validation tool

(2017) Heping Zheng et al.   Acta Crystallographica Section D-Structural Biology

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach

(2017) Sneha P. et al.   PLoS One

Protein folding alterations in amyotrophic lateral sclerosis

(2016) Sonam Parakh et al.   BRAIN RESEARCH

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

(2016) Simran J. Kaur et al.   GENE

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Amyotrophic Lateral Sclerosis Type 20 - In Silico Analysis and Molecular Dynamics Simulation of hnRNPA1

(2016) Bruna Baumgarten Krebs et al.   PLoS One

Computational investigation of curcumin, a natural polyphenol that inhibits the destabilization and the aggregation of human SOD1 mutant (Ala4Val)

(2016) E. Srinivasan et al.   RSC Advances

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons

(2016) Jurate Lasiene et al.   Acta Neuropathologica Communications

Arresting Amyloid with Coulomb’s Law: Acetylation of ALS-Linked SOD1 by Aspirin Impedes Aggregation

(2015) Alireza Abdolvahabi et al.   BIOPHYSICAL JOURNAL

Metal-deficient SOD1 in amyotrophic lateral sclerosis

(2015) James B. Hilton et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic

(2015) Renzo Mancuso et al.   PROGRESS IN NEUROBIOLOGY

Automatic Identification of Mobile and Rigid Substructures in Molecular Dynamics Simulations and Fractional Structural Fluctuation Analysis

(2015) Leandro Martínez   PLoS One

Identification of a Misfolded Region in Superoxide Dismutase 1 That Is Exposed in Amyotrophic Lateral Sclerosis

(2014) Melissa S. Rotunno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and dynamics of TIP3P, TIP4P, and TIP5P water near smooth and atomistic walls of different hydroaffinity

(2014) Michael F. Harrach et al.   JOURNAL OF CHEMICAL PHYSICS

Molecular Dynamics Simulations and Principal Component Analysis on Human Laforin Mutation W32G and W32G/K87A

(2014) P. S. Srikumar et al.   PROTEIN JOURNAL

PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations

(2014) Jaroslav Bendl et al.   PLoS Computational Biology

ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function

(2013) Gershon Celniker et al.   ISRAEL JOURNAL OF CHEMISTRY

Elevated serum autoantibody against high mobility group box 1 as a potent surrogate biomarker for amyotrophic lateral sclerosis

(2013) Chi-Shin Hwang et al.   NEUROBIOLOGY OF DISEASE

Structural and Functional Analysis of Human SOD1 in Amyotrophic Lateral Sclerosis

(2013) Lorenna Giannini Alves Moreira et al.   PLoS One

Protein misfolding in the late-onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis

(2013) Vikram Khipple Mulligan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics

(2012) Olubunmi Abel et al.   HUMAN MUTATION

Predicting the Functional Effect of Amino Acid Substitutions and Indels

(2012) Yongwook Choi et al.   PLoS One

A novel codon4 mutation (A4F) in the SOD1gene in familial amyotrophic lateral sclerosis

(2011) Wonki Baek et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Structures of mouse SOD1 and human/mouse SOD1 chimeras

(2010) Sai V. Seetharaman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Determination of Ensemble-Average Pairwise Root Mean-Square Deviation from Experimental B-Factors

(2010) Antonija Kuzmanic et al.   BIOPHYSICAL JOURNAL

Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis

(2008) Xiaohang Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY