An evolving tale of two interacting RNAs-themes and variations of the T-box riboswitch mechanism

Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria

(2019) Kyla M. Frohlich et al.   ChemMedChem

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

New tRNA contacts facilitate ligand binding in aMycobacterium smegmatisT box riboswitch

(2018) Anna V. Sherwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical mechanism of amino acid sensing by the T-box riboswitch

(2018) Krishna C. Suddala et al.   Nature Communications

Specific structural elements of the T-box riboswitch drive the two-step binding of the tRNA ligand

(2018) Jiacheng Zhang et al.   eLife

Molecular envelope and atomic model of an anti-terminated glyQS T-box regulator in complex with tRNAGly

(2017) Bhaskar Chetnani et al.   NUCLEIC ACIDS RESEARCH

Direct modulation of T-box riboswitch-controlled transcription by protein synthesis inhibitors

(2017) Vassiliki Stamatopoulou et al.   NUCLEIC ACIDS RESEARCH

The Kink Turn, a Key Architectural Element in RNA Structure

(2016) Lin Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts

(2016) Arlie J. Rinaldi et al.   Nature Communications

Codon-Anticodon Recognition in theBacillus subtilis glyQST Box Riboswitch

(2015) Enrico Caserta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T box riboswitches in Actinobacteria: Translational regulation via novel tRNA interactions

(2015) Anna V. Sherwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AglyST-box riboswitch with species-specific structural features responding to both proteinogenic and nonproteinogenic tRNAGlyisoacceptors

(2015) Maria Apostolidi et al.   RNA

Structure and mechanism of the T-box riboswitches

(2015) Jinwei Zhang et al.   Wiley Interdisciplinary Reviews-RNA

The T box riboswitch: A novel regulatory RNA that utilizes tRNA as its ligand

(2014) Tina M. Henkin   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Single-molecule studies of riboswitch folding

(2014) Andrew Savinov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Direct Evaluation of tRNA Aminoacylation Status by the T-Box Riboswitch Using tRNA-mRNA Stacking and Steric Readout

(2014) Jinwei Zhang et al.   MOLECULAR CELL

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

(2014) M. H. Larson et al.   SCIENCE

Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA

(2013) Jinwei Zhang et al.   NATURE

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

A universal RNA structural motif docking the elbow of tRNA in the ribosome, RNAse P and T-box leaders

(2013) Jean Lehmann et al.   NUCLEIC ACIDS RESEARCH

Two-codon T-box riboswitch binding two tRNAs

(2013) N. Y. Saad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T box RNA decodes both the information content and geometry of tRNA to affect gene expression

(2013) J. C. Grigg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular recognition of kink-turn structure by the L7Ae class of proteins

(2013) L. Huang et al.   RNA

Structural Determinants for Geometry and Information Decoding of tRNA by T Box Leader RNA

(2013) Jason C. Grigg et al.   STRUCTURE

YbxF and YlxQ are bacterial homologs of L7Ae and bind K-turns but not K-loops

(2012) N. J. Baird et al.   RNA

Riboswitches: Discovery of Drugs That Target Bacterial Gene-Regulatory RNAs

(2011) Katherine E. Deigan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and Stereospecificity of 4,5-Disubstituted Oxazolidinone Ligands Binding to T-box Riboswitch RNA

(2011) Crina M. Orac et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution Structure of the K-Turn and Specifier Loop Domains from the Bacillus subtilis tyrS T-Box Leader RNA

(2011) Jiachen Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribozymes and Riboswitches: Modulation of RNA Function by Small Molecules

(2010) Jinwei Zhang et al.   BIOCHEMISTRY

Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA

(2010) Nicholas J. Reiter et al.   NATURE

NMR structure and dynamics of the Specifier Loop domain from the Bacillus subtilis tyrS T box leader RNA

(2010) Jiachen Wang et al.   NUCLEIC ACIDS RESEARCH

A switch in time: Detailing the life of a riboswitch

(2009) Andrew D. Garst et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The T box mechanism: tRNA as a regulatory molecule

(2009) Nicholas J. Green et al.   FEBS LETTERS

Biochemical Features and Functional Implications of the RNA-Based T-Box Regulatory Mechanism

(2009) A. Gutierrez-Preciado et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Identification of neomycin B-binding site in T box antiterminator model RNA

(2008) Rajaneesh Anupam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function

(2008) Rajaneesh Anupam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Riboswitch RNAs: using RNA to sense cellular metabolism

(2008) T. M. Henkin   GENES & DEVELOPMENT

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS

Comparative genomic analysis of T-box regulatory systems in bacteria

(2008) A. G. Vitreschak et al.   RNA