Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria

Bacterial Adaptation to Antibiotics through Regulatory RNAs

(2018) Brice Felden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcriptional regulators: valuable targets for novel antibacterial strategies

(2018) Andrés González et al.   Future Medicinal Chemistry

Drugging tRNA aminoacylation

(2018) Joanne M. Ho et al.   RNA Biology

The Search for ‘Evolution-Proof’ Antibiotics

(2018) Graham Bell et al.   TRENDS IN MICROBIOLOGY

Cationic Branched Polyethylenimine (BPEI) Disables Antibiotic Resistance in Methicillin-Resistant Staphylococcus epidermidis (MRSE)

(2018) Anh K. Lam et al.   ChemMedChem

Drugging the RNA World

(2018) Matthew D. Disney et al.   Cold Spring Harbor Perspectives in Biology

Direct modulation of T-box riboswitch-controlled transcription by protein synthesis inhibitors

(2017) Vassiliki Stamatopoulou et al.   NUCLEIC ACIDS RESEARCH

Potential and use of bacterial small RNAs to combat drug resistance: a systematic review

(2017) Hung Chan et al.   Infection and Drug Resistance

Emerging applications of riboswitches – from antibacterial targets to molecular tools

(2016) Piotr Machtel et al.   JOURNAL OF APPLIED GENETICS

Insights into the Mechanism of Inhibition of Novel Bacterial Topoisomerase Inhibitors from Characterization of Resistant Mutants of Staphylococcus aureus

(2015) Sushmita D. Lahiri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation

(2015) Marcin Mielczarek et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Codon-Anticodon Recognition in theBacillus subtilis glyQST Box Riboswitch

(2015) Enrico Caserta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective small-molecule inhibition of an RNA structural element

(2015) John A. Howe et al.   NATURE

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

(2015) James Palacino et al.   Nature Chemical Biology

The importance of being modified: an unrealized code to RNA structure and function

(2015) Paul F. Agris   RNA

Bacterial Transcription Inhibitor of RNA Polymerase Holoenzyme Formation by Structure-Based Drug Design: From in Silico Screening to Validation

(2015) Cong Ma et al.   ACS Infectious Diseases

Sequence-based design of bioactive small molecules that target precursor microRNAs

(2014) Sai Pradeep Velagapudi et al.   Nature Chemical Biology

Solution NMR determination of hydrogen bonding and base pairing between theglyQST box riboswitch Specifier domain and the anticodon loop of tRNAGly

(2013) Andrew T. Chang et al.   FEBS LETTERS

Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA

(2013) Jinwei Zhang et al.   NATURE

T box RNA decodes both the information content and geometry of tRNA to affect gene expression

(2013) J. C. Grigg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the bacteria–host interface

(2013) Anne Marie Krachler et al.   Virulence

Early phase drug discovery: Cheminformatics and computational techniques in identifying lead series

(2012) Bryan C. Duffy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target

(2012) Andrew Robinson et al.   CURRENT DRUG TARGETS

Acquired inducible antimicrobial resistance in Gram-positive bacteria

(2012) Scott T Chancey et al.   Future Microbiology

Analysis of Cell Cycle and Replication of Mouse Macrophages afterIn VivoandIn VitroCryptococcus neoformans Infection Using Laser Scanning Cytometry

(2012) Carolina Coelho et al.   INFECTION AND IMMUNITY

Riboswitches: Discovery of Drugs That Target Bacterial Gene-Regulatory RNAs

(2011) Katherine E. Deigan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structure–activity studies of RNA-binding oxazolidinone derivatives

(2011) Iwona Maciagiewicz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles

(2011) S. Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ligand-Induced Changes in T Box Antiterminator RNA Stability

(2011) Shu Zhou et al.   Chemical Biology & Drug Design

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

(2011) A.-P. Magiorakos et al.   CLINICAL MICROBIOLOGY AND INFECTION

Synthesis and Stereospecificity of 4,5-Disubstituted Oxazolidinone Ligands Binding to T-box Riboswitch RNA

(2011) Crina M. Orac et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution Structure of the K-Turn and Specifier Loop Domains from the Bacillus subtilis tyrS T-Box Leader RNA

(2011) Jiachen Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

(2010) Stephen Hanessian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

NMR structure and dynamics of the Specifier Loop domain from the Bacillus subtilis tyrS T box leader RNA

(2010) Jiachen Wang et al.   NUCLEIC ACIDS RESEARCH

Riboswitch RNAs: Regulation of gene expression by direct monitoring of a physiological signal

(2010) Angela M. Smith et al.   RNA Biology

Antibiotics that target protein synthesis

(2010) Lisa S. McCoy et al.   Wiley Interdisciplinary Reviews-RNA

Statistical methods for automated drug susceptibility testing: Bayesian minimum inhibitory concentration prediction from growth curves

(2009) Xi Kathy Zhou et al.   Annals of Applied Statistics

Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis

(2009) B. M. Hall et al.   BIOINFORMATICS

Antimicrobial Susceptibility Testing: A Review of General Principles and Contemporary Practices

(2009) James H. Jorgensen et al.   CLINICAL INFECTIOUS DISEASES

The T box mechanism: tRNA as a regulatory molecule

(2009) Nicholas J. Green et al.   FEBS LETTERS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Biochemical Features and Functional Implications of the RNA-Based T-Box Regulatory Mechanism

(2009) A. Gutierrez-Preciado et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Identification of neomycin B-binding site in T box antiterminator model RNA

(2008) Rajaneesh Anupam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function

(2008) Rajaneesh Anupam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Riboswitch RNAs: using RNA to sense cellular metabolism

(2008) T. M. Henkin   GENES & DEVELOPMENT

The Research Agenda of the National Institute of Allergy and Infectious Diseases for Antimicrobial Resistance

(2008) N. Kent Peters et al.   JOURNAL OF INFECTIOUS DISEASES

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two-Dimensional Combinatorial Screening Identifies Specific Aminoglycoside−RNA Internal Loop Partners

(2008) Matthew D. Disney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

(2008) Irith Wiegand et al.   Nature Protocols

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Comparative genomic analysis of T-box regulatory systems in bacteria

(2008) A. G. Vitreschak et al.   RNA