The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance

(2018) Anna Di Fiore et al.   Oxidative Medicine and Cellular Longevity

Systems analysis of intracellular pH vulnerabilities for cancer therapy

(2018) Erez Persi et al.   Nature Communications

The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy

(2018) Elena Andreucci et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility

(2018) Emma J. Mah et al.   Scientific Reports

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

(2017) Katharine A. White et al.   JOURNAL OF CELL SCIENCE

Targeting pH regulating proteins for cancer therapy–Progress and limitations

(2017) Scott K. Parks et al.   SEMINARS IN CANCER BIOLOGY

Value of pH regulators in the diagnosis, prognosis and treatment of cancer

(2017) Sara Granja et al.   SEMINARS IN CANCER BIOLOGY

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

(2017) Salvador Harguindey et al.   SEMINARS IN CANCER BIOLOGY

Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

(2017) Christian Stock et al.   SEMINARS IN CANCER BIOLOGY

Proton pump inhibition and cancer therapeutics: A specific tumor targeting or it is a phenomenon secondary to a systemic buffering?

(2017) Enrico Spugnini et al.   SEMINARS IN CANCER BIOLOGY

The effect of pH on cell viability, cell migration, cell proliferation, wound closure, and wound reepithelialization: In vitro and in vivo study

(2017) Carla R. Kruse et al.   WOUND REPAIR AND REGENERATION

Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

(2017) Marina V. Shirmanova et al.   Scientific Reports

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

(2017) Ayano Kondo et al.   Cell Reports

Na + /H + antiporter (NHE1) and lactate/H + symporters (MCTs) in pH homeostasis and cancer metabolism

(2016) Laurent Counillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor metabolism, cancer cell transporters, and microenvironmental resistance

(2016) Khalid O. Alfarouk   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells

(2016) Su Chii Kong et al.   PANCREAS

Acceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts

(2016) Gunhyuk Park et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

(2016) Scott K. Parks et al.   Oncotarget

Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo

(2016) Avik Som et al.   Scientific Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

(2016) Cung Hoa Thien Quach et al.   PLoS One

A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology

(2015) Romeo Gabriel Mihaila   BIOMEDICAL PAPERS-OLOMOUC

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

(2015) Ibtissam Marchiq et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

pH Gradient Reversal: An Emerging Hallmark of Cancers

(2015) Mohit Sharma et al.   Recent Patents on Anti-Cancer Drug Discovery

Focal adhesion signaling and therapy resistance in cancer

(2015) Iris Eke et al.   SEMINARS IN CANCER BIOLOGY

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

(2015) Paul C. McDonald et al.   Oncotarget

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

(2015) Ilaria Giusti et al.   NEOPLASIA

Vascular measurements correlate with estrogen receptor status

(2014) Mark C Lloyd et al.   BMC CANCER

Beyond Warburg effect – dual metabolic nature of cancer cells

(2014) Jiansheng Xie et al.   Scientific Reports

Considering Protonation as a Posttranslational Modification Regulating Protein Structure and Function

(2013) André Schönichen et al.   Annual Review of Biophysics

Human carbonic anhydrase VII protects cells from oxidative damage

(2013) Rita Del Giudice et al.   BIOLOGICAL CHEMISTRY

Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway

(2013) Zhiqiang Zhao et al.   CANCER LETTERS

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Cancer metabolism, stemness and tumor recurrence

(2013) Joseph M. Curry et al.   CELL CYCLE

Antinociceptive Effects of Amiloride and Benzamil in Neuropathic Pain Model Rats

(2013) Seongtae Jeong et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

(2013) Salvador Harguindey et al.   Journal of Translational Medicine

The effect of pH on the self-assembly of a collagen derived peptide amphiphile

(2013) Ashkan Dehsorkhi et al.   Soft Matter

The Origin of Membrane Bioenergetics

(2012) Nick Lane et al.   CELL

Inside Out: Targeting NHE1 as an Intracellular and Extracellular Regulator of Cancer Progression

(2012) Joseph J. Provost et al.   Chemical Biology & Drug Design

Physiology, Pharmacology and Pathophysiology of the pH Regulatory Transport Proteins NHE1 and NBCn1: Similarities, Differences, and Implications for Cancer Therapy

(2012) E. Boedtkjer et al.   CURRENT PHARMACEUTICAL DESIGN

Riparian ecosystems in human cancers

(2012) Khalid O. Alfarouk et al.   Evolutionary Applications

Role of monocarboxylate transporters in human cancers: state of the art

(2012) Céline Pinheiro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The renaissance of mitochondrial pH

(2012) Jaime Santo-Domingo et al.   JOURNAL OF GENERAL PHYSIOLOGY

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

(2012) Kivanç Birsoy et al.   NATURE GENETICS

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Mitochondrial Evolution

(2012) M. W. Gray   Cold Spring Harbor Perspectives in Biology

Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs

(2011) X. Tang et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Dual Role of CO2/HCO3−Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths

(2011) Alzbeta Hulikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes mellitus type 2 through oncology lens

(2011) Khalid Omer Alfarouk et al.   MEDICAL HYPOTHESES

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Imaging pH and metastasis

(2011) Arig Ibrahim Hashim et al.   NMR IN BIOMEDICINE

The Spatial Organization of Proton and Lactate Transport in a Rat Brain Tumor

(2011) Emmanuelle Grillon et al.   PLoS One

Tumor Acidity as Evolutionary Spite

(2011) Khalid O. Alfarouk et al.   Cancers

Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)

(2011) Khalid O. Alfarouk et al.   Cancers

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

(2010) Giovanni Busco et al.   FASEB JOURNAL

Leaky vessels as a potential source of stromal acidification in tumours

(2010) Natasha K. Martin et al.   JOURNAL OF THEORETICAL BIOLOGY

Tumour–stromal interactions in acid-mediated invasion: A mathematical model

(2010) Natasha K. Martin et al.   JOURNAL OF THEORETICAL BIOLOGY

Proton dynamics in cancer

(2010) Veronica Huber et al.   Journal of Translational Medicine

Diverse evolutionary paths to cell adhesion

(2010) Monika Abedin et al.   TRENDS IN CELL BIOLOGY

Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

(2010) Julia Ling-Yu Chen et al.   PLoS Genetics

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Acid treatment of melanoma cells selects for invasive phenotypes

(2008) Raymond E. Moellering et al.   CLINICAL & EXPERIMENTAL METASTASIS

Carbonic Anhydrases An Overview

(2008) Claudiu Supuran   CURRENT PHARMACEUTICAL DESIGN

Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats

(2008) Arunachalam Muthuraman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers

(2008) Julia Ling-Yu Chen et al.   PLoS Genetics