Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects

Ketamine-Induced Apoptosis in Normal Human Urothelial Cells

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Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse

(2016) Yan Zhang et al.   BIOLOGICAL PSYCHIATRY

Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine

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Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity

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Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

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Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

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EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress

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Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories

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Depression as a Glial-Based Synaptic Dysfunction

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Ketamine Inside Neurons?

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Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression

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NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism

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Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

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AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation

(2015) Ying Han et al.   NEUROPSYCHOPHARMACOLOGY

Astrocytic Actions on Extrasynaptic Neuronal Currents

(2015) Balázs Pál   Frontiers in Cellular Neuroscience

Restoring Mood Balance in Depression: Ketamine Reverses Deficit in Dopamine-Dependent Synaptic Plasticity

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Synaptic Glutamate Spillover Due to Impaired Glutamate Uptake Mediates Heroin Relapse

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Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

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Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats

(2013) Wei-Li Zhu et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism

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Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects

(2012) Henry A. Lester et al.   BIOLOGICAL PSYCHIATRY

Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression

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Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

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A Randomized, Placebo-Controlled, Crossover Pilot Trial of the Oral Selective NR2B Antagonist MK-0657 in Patients With Treatment-Resistant Major Depressive Disorder

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Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

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Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training

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PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3

(2012) Hai-Shui Shi et al.   NEUROPSYCHOPHARMACOLOGY

Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia

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Chronic Ketamine Administration Modulates Midbrain Dopamine System in Mice

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Synaptic Dysfunction in Depression: Potential Therapeutic Targets

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Distribution of Extrasynaptic NMDA Receptors on Neurons

(2012) Ronald S. Petralia   TheScientificWorldJOURNAL

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

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Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity

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Evaluation of sigma (σ) receptors in the antidepressant-like effects of ketamine in vitro and in vivo

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Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

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Effects of Ifenprodil on Morphine-Induced Conditioned Place Preference and Spatial Learning and Memory in Rats

(2010) Yao-Ying Ma et al.   NEUROCHEMICAL RESEARCH

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Emerging role of glutamate in the pathophysiology of major depressive disorder

(2009) Kenji Hashimoto   BRAIN RESEARCH REVIEWS

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

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Identification of Death-Associated Protein Kinases Inhibitors Using Structure-Based Virtual Screening

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

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Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression

(2009) M. Zink et al.   NEUROPHARMACOLOGY

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY