AAV9-mediated delivery of miR-23a reduces disease severity in Smn2B/−SMA model mice

CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis

(2018) Eva Janzen et al.   BRAIN

MiR-142-3p Enhances Cell Viability and Inhibits Apoptosis by Targeting CDKN1B and TIMP3 Following Sciatic Nerve Injury

(2018) Dong-Mei Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Skeletal Muscle MicroRNAs as Key Players in the Pathogenesis of Amyotrophic Lateral Sclerosis

(2018) Lorena Di Pietro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron

(2018) Kelsey M. Gray et al.   MOLECULAR BIOLOGY OF THE CELL

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

(2018) Eugenio Mercuri et al.   NEW ENGLAND JOURNAL OF MEDICINE

miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk

(2018) Aiqing Zhang et al.   Journal of Cachexia Sarcopenia and Muscle

Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy

(2017) Samantha L. Sison et al.   HUMAN MOLECULAR GENETICS

microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

(2017) Loredana Leggio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis

(2017) Paola Rinchetti et al.   MOLECULAR NEUROBIOLOGY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNAs in Parkinson's disease and emerging therapeutic targets

(2017) PhilipV Peplow et al.   Neural Regeneration Research

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

(2017) Jerry R. Mendell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

(2017) Richard S. Finkel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of miR-23a increases the sensitivity of lung cancer stem cells to erlotinib through PTEN/PI3K/Akt pathway

(2017) Zhijun Han et al.   ONCOLOGY REPORTS

Biomarker Potential of Extracellular miRNAs in Duchenne Muscular Dystrophy

(2017) Anna M.L. Coenen-Stass et al.   TRENDS IN MOLECULAR MEDICINE

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly

(2017) Paul G. Donlin-Asp et al.   Cell Reports

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases

(2017) Rachel A. Kline et al.   PLoS Genetics

The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype

(2016) Seyyedmohsen Hosseinibarkooie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset

(2016) Zhihua Feng et al.   HUMAN MOLECULAR GENETICS

Effect of genetic background on the phenotype of theSmn2B/-mouse model of spinal muscular atrophy

(2016) Mehdi Eshraghi et al.   HUMAN MOLECULAR GENETICS

Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy

(2016) Mary H. Wertz et al.   HUMAN MOLECULAR GENETICS

Neuroprotective Role of MicroRNA-22 in a 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease via Regulation of Its Target Gene TRPM7

(2016) Chao Ping Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration

(2016) Songlin Zhou et al.   Neuroscience Bulletin

Altered Levels of MicroRNA-9, -206, and -132 in Spinal Muscular Atrophy and Their Response to Antisense Oligonucleotide Therapy

(2016) Francesco Catapano et al.   Molecular Therapy-Nucleic Acids

Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells

(2016) Sara K. Custer et al.   PLoS One

MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma

(2015) K Tian et al.   CANCER GENE THERAPY

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

(2015) Shi-Yan Ng et al.   Cell Stem Cell

PTEN Depletion Decreases Disease Severity and Modestly Prolongs Survival in a Mouse Model of Spinal Muscular Atrophy

(2015) Daniel Little et al.   MOLECULAR THERAPY

MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration

(2015) Akshay Bhinge et al.   STEM CELLS

Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

(2015) Lyndsay M. Murray et al.   Acta Neuropathologica Communications

SMN regulates axonal local translation via miR-183/mTOR pathway

(2014) Min Jeong Kye et al.   HUMAN MOLECULAR GENETICS

Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

(2014) Thomas M. Wishart et al.   JOURNAL OF CLINICAL INVESTIGATION

Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins

(2014) B. Sabirzhanov et al.   JOURNAL OF NEUROSCIENCE

Survival of motor neuron protein downregulates miR-9 expression in patients with spinal muscular atrophy

(2014) Li-Ting Wang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes

(2014) Yves Maury et al.   NATURE BIOTECHNOLOGY

miRDB: an online resource for microRNA target prediction and functional annotations

(2014) Nathan Wong et al.   NUCLEIC ACIDS RESEARCH

Transcriptome Profiling of Spinal Muscular Atrophy Motor Neurons Derived from Mouse Embryonic Stem Cells

(2014) Miho Maeda et al.   PLoS One

Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation

(2014) Lena Saal et al.   RNA

MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis

(2014) Q Chen et al.   Cell Death & Disease

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export

(2013) Matthew B. Hudson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The MicroRNA-17-92 Cluster Enhances Axonal Outgrowth in Embryonic Cortical Neurons

(2013) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy

(2013) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-23a promotes myelination in the central nervous system

(2013) S.-T. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-9: a versatile regulator of neurogenesis

(2013) Marion Coolen et al.   Frontiers in Cellular Neuroscience

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

(2012) Melissa Bowerman et al.   BMC Medicine

Spinal muscular atrophy: The role of SMN in axonal mRNA regulation

(2012) Claudia Fallini et al.   BRAIN RESEARCH

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons

(2012) Y. M. Clovis et al.   DEVELOPMENT

Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation

(2012) Aldrin V. Gomes et al.   FASEB JOURNAL

Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy

(2012) Dhruv Sareen et al.   PLoS One

Direct central nervous system delivery provides enhanced protection following vector mediated gene replacement in a severe model of Spinal Muscular Atrophy

(2011) Jacqueline J. Glascock et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translational Suppression of Atrophic Regulators by MicroRNA-23a Integrates Resistance to Skeletal Muscle Atrophy

(2011) Shogo Wada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early Functional Impairment of Sensory-Motor Connectivity in a Mouse Model of Spinal Muscular Atrophy

(2011) George Z. Mentis et al.   NEURON

SMN in spinal muscular atrophy and snRNP biogenesis

(2011) Tristan H. Coady et al.   Wiley Interdisciplinary Reviews-RNA

PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons

(2010) Ke Ning et al.   HUMAN MOLECULAR GENETICS

Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice

(2010) Elisa Dominguez et al.   HUMAN MOLECULAR GENETICS

CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy

(2010) Marco A. Passini et al.   JOURNAL OF CLINICAL INVESTIGATION

Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy

(2010) Karen K. Y. Ling et al.   PLoS One

Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice

(2009) L. Kong et al.   JOURNAL OF NEUROSCIENCE

Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy

(2009) Dirk Bäumer et al.   PLoS Genetics

Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy

(2008) Shingo Kariya et al.   HUMAN MOLECULAR GENETICS

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Plastin 3 Is a Protective Modifier of Autosomal Recessive Spinal Muscular Atrophy

(2008) G. E. Oprea et al.   SCIENCE