Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

Validating the concept of mutational signatures with isogenic cell models

(2018) Xueqing Zou et al.   Nature Communications

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

(2018) Francis Blokzijl et al.   Genome Medicine

Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors

(2017) Mi Ni Huang et al.   GENOME RESEARCH

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Multi-organ Mapping of Cancer Risk

(2016) Liqin Zhu et al.   CELL

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes

(2016) Dilmi Perera et al.   NATURE

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

(2016) Jaegil Kim et al.   NATURE GENETICS

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

(2016) Ewart W. Kuijk et al.   Scientific Reports

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

(2015) Peter D. Adams et al.   Cell Stem Cell

Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation

(2015) Marjo-Riitta Puumalainen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease

(2015) Aurélie Dupuy et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

Genome sequencing of normal cells reveals developmental lineages and mutational processes

(2014) Sam Behjati et al.   NATURE

Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Association of ERCC1 and ERCC2 polymorphisms with colorectal cancer risk in a Chinese population

(2014) Min Ni et al.   Scientific Reports

Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes

(2014) Christina L. Zheng et al.   Cell Reports

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines

(2013) N. P. Degtyareva et al.   NUCLEIC ACIDS RESEARCH

DELLY: structural variant discovery by integrated paired-end and split-read analysis

(2012) T. Rausch et al.   BIOINFORMATICS

Oxidatively generated complex DNA damage: Tandem and clustered lesions

(2012) Jean Cadet et al.   CANCER LETTERS

Multiple DNA Binding Domains Mediate the Function of the ERCC1-XPF Protein in Nucleotide Excision Repair

(2012) Yan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin organization is a major influence on regional mutation rates in human cancer cells

(2012) Benjamin Schuster-Böckler et al.   NATURE

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

(2011) Valentina Boeva et al.   BIOINFORMATICS

A mouse model of accelerated liver aging caused by a defect in DNA repair

(2011) Siobhán Q. Gregg et al.   HEPATOLOGY

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair

(2010) Jennifer J. Rahn et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

HObullet radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases

(2010) F. Bergeron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Mouse Models for Xeroderma Pigmentosum Group A and Group C Show Divergent Cancer Phenotypes

(2008) J. P.M. Melis et al.   CANCER RESEARCH

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE