Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors

Genetic Features of Aflatoxin-Associated Hepatocellular Carcinoma

(2017) Weilong Zhang et al.   GASTROENTEROLOGY

Mutational spectra of aflatoxin B1in vivo establish biomarkers of exposure for human hepatocellular carcinoma

(2017) Supawadee Chawanthayatham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(2016) Akihiro Fujimoto et al.   NATURE GENETICS

Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism

(2015) Ariane Ambolet-Camoit et al.   BIOCHIMIE

Molecular characterization of hepatocarcinogenesis using mouse models

(2015) W. W. Teoh et al.   Disease Models & Mechanisms

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

(2015) Jinchuan Hu et al.   GENES & DEVELOPMENT

The genome as a record of environmental exposure

(2015) Serena Nik-Zainal et al.   MUTAGENESIS

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Mutation signatures implicate aristolochic acid in bladder cancer development

(2015) Song Ling Poon et al.   Genome Medicine

Prevalence of Aflatoxin Induced p53 Mutation at Codon 249 (R249s) in Hepatocellular Carcinoma Patients with and without Hepatitis B Surface Antigen (HBsAg)

(2014) Salyavit Chittmittrapap et al.   Asian Pacific Journal of Cancer Prevention

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

(2014) Ludmil B Alexandrov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

C. eleganswhole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

(2014) Bettina Meier et al.   GENOME RESEARCH

Mechanisms underlying mutational signatures in human cancers

(2014) Thomas Helleday et al.   NATURE REVIEWS GENETICS

Mutation signatures of carcinogen exposure: genome-wide detection and new opportunities for cancer prevention

(2014) Song Poon et al.   Genome Medicine

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

(2013) S. L. Poon et al.   Science Translational Medicine

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

(2013) M. L. Hoang et al.   Science Translational Medicine

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

A map of the cis-regulatory sequences in the mouse genome

(2012) Yin Shen et al.   NATURE

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

(2012) Wing-Kin Sung et al.   NATURE GENETICS

Co-contamination of aflatoxin B1and fumonisin B1in food and human dietary exposure in three areas of China

(2011) G. Sun et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

(2010) T. W. Kensler et al.   TOXICOLOGICAL SCIENCES

TP53 R249S Mutations, Exposure to Aflatoxin, and Occurrence of Hepatocellular Carcinoma in a Cohort of Chronic Hepatitis B Virus Carriers from Qidong, China

(2009) K. Szymanska et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects

(2008) Maria Fousteri et al.   CELL RESEARCH