Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

(2015) Giulio Maria Pasinetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats

(2015) Sobhana George Sugin Lal Jabaris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PDE-4 Inhibition Rescues Aberrant Synaptic Plasticity in Drosophila and Mouse Models of Fragile X Syndrome

(2015) C. H. Choi et al.   JOURNAL OF NEUROSCIENCE

Longterm (52-week) Results of a Phase III Randomized, Controlled Trial of Apremilast in Patients with Psoriatic Arthritis

(2015) A. Kavanaugh et al.   JOURNAL OF RHEUMATOLOGY

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial

(2015) Fernando J Martinez et al.   LANCET

Conditions Affecting Social Space in Drosophila melanogaster

(2015) Alison R. McNeil et al.   Jove-Journal of Visualized Experiments

Metabolic effects of resveratrol: addressing the controversies

(2014) Jacob L. Bitterman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse

(2014) S H Kim et al.   MOLECULAR PSYCHIATRY

Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions

(2014) Franck R. Petry et al.   PLoS One

Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders

(2013) Kenji Hashimoto et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

(2013) Annalisa Cavallini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological and Genetic Reversal of Age-Dependent Cognitive Deficits Attributable to Decreased presenilin Function

(2013) S. M. J. McBride et al.   JOURNAL OF NEUROSCIENCE

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

(2013) Yuan-Shih Hu et al.   PLoS One

The Drosophila DmGluRA is required for social interaction and memory

(2013) Brian P. Schoenfeld et al.   Frontiers in Pharmacology

Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012

(2012) Bruce J. Melancon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Examination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice

(2012) Marjelo A. Mines et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

(2012) C. A. Hoeffer et al.   GENES BRAIN AND BEHAVIOR

Learning and Memory Deficits Consequent to Reduction of the Fragile X Mental Retardation Protein Result from Metabotropic Glutamate Receptor-Mediated Inhibition of cAMP Signaling in Drosophila

(2012) A. K. Kanellopoulos et al.   JOURNAL OF NEUROSCIENCE

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Social structures depend on innate determinants and chemosensory processing in Drosophila

(2012) J. Schneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic benefits of inhibiting cAMP-PDEs with resveratrol

(2012) Jay H. Chung   Adipocyte

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

(2011) Jianling Xie et al.   CELLULAR SIGNALLING

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

(2011) Magali Dumont et al.   FASEB JOURNAL

An Open-Label Naturalistic Pilot Study of Acamprosate in Youth with Autistic Disorder

(2011) Craig A. Erickson et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome

(2011) Zhong-Hua Liu et al.   NEUROBIOLOGY OF DISEASE

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice

(2011) Cara J. Westmark et al.   PLoS One

A prospective open-label study of aripiprazole in fragile X syndrome

(2011) Craig A. Erickson et al.   PSYCHOPHARMACOLOGY

Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

(2011) S. Jacquemont et al.   Science Translational Medicine

Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome

(2011) Marjelo A. Mines et al.   Frontiers in Molecular Neuroscience

Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment

(2010) Catherine H. Choi et al.   BRAIN RESEARCH

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

An assay for social interaction in Drosophila fragile X mutants

(2010) Francois V. Bolduc et al.   FLY

Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome

(2010) Zhong-Hua Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Short- and Long-Term Memory Are Modulated by Multiple Isoforms of the Fragile X Mental Retardation Protein

(2010) P. Banerjee et al.   JOURNAL OF NEUROSCIENCE

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome

(2009) Christopher J. Yuskaitis et al.   BIOCHEMICAL PHARMACOLOGY

Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue

(2009) Catherine H. Choi et al.   BIOGERONTOLOGY

Inhibition of GSK-3β enhances reovirus-induced apoptosis in colon cancer cells

(2009) Chung   INTERNATIONAL JOURNAL OF ONCOLOGY

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits

(2009) S. B. Christie et al.   JOURNAL OF NEUROSCIENCE

Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome

(2008) Ning Weng et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Autism and Brain Development

(2008) Christopher A. Walsh et al.   CELL

Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity

(2008) Christopher J. Yuskaitis et al.   CELLULAR SIGNALLING

Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome

(2008) Elizabeth Berry-Kravis et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling

(2008) Luyuan Pan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory

(2008) François V Bolduc et al.   NATURE NEUROSCIENCE

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

(2008) Femke M.S. de Vrij et al.   NEUROBIOLOGY OF DISEASE

Metabotropic Glutamate Receptor-Mediated LTD Involves Two Interacting Ca2+ Sensors, NCS-1 and PICK1

(2008) Jihoon Jo et al.   NEURON

Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential

(2008) Wenzhong William Min et al.   NEUROPHARMACOLOGY