Article
Oncology
Annasofia Anemone, Lorena Consolino, Laura Conti, Pietro Irrera, Myriam Y. Hsu, Daisy Villano, Walter Dastru, Paolo E. Porporato, Federica Cavallo, Dario Livio Longo
Summary: This study found that extracellular acidification is associated with metastatic potential, with tumors of higher metastatic potential showing more acidic pH. The marker of CD44(+)CD24(-) is indicative of highly invasive tumors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Marion de Vevey, Alice Bouchard, Adrian Soldati, Klaus Zuberbuhler
Summary: Chimpanzees use nose skin temperature to express cooperative and competitive social events, and these perceptions are moderated by specific audiences.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kristin Roseth Aass, Robin Mjelle, Martin H. Kastnes, Synne S. Tryggestad, Luca M. van den Brink, Ingrid Aass Roseth, Marita Westhrin, Muhammad Zahoor, Siv H. Moen, Tonje M. Vikene Nedal, Glenn Buene, Kristine Misund, Anne-Marit Sponaas, Qianli Ma, Anders Sundan, Richard W. J. Groen, Tobias S. Slordahl, Anders Waage, Therese Standal
Summary: This study demonstrates an unrecognized role of IL-32 in the regulation of plasma cell metabolism. IL-32 interacts with components of the mitochondrial respiratory chain and promotes oxidative phosphorylation. Knocking out IL-32 reduces cell survival and proliferation in myeloma cells, and perturbs metabolic pathways.
Article
Multidisciplinary Sciences
Jingjing Liu, Gaosheng Zhou, Rongping Chen, Zewen Tong, Hongmin Zhang, Xiaoting Wang, Dawei Liu
Summary: The study found that the serum levels of Sirt3 are associated with disease severity in septic patients, suggesting that Sirt3 could be a potential novel marker for sepsis diagnosis and mortality prediction.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Matthew Zorkau, Christin A. Albus, Rolando Berlinguer-Palmini, Zofia M. A. Chrzanowska-Lightowlers, Robert N. Lightowlers
Summary: The majority of mitochondrial protein synthesis in human cells occurs at the cristae membranes, spatially separated from the sites of RNA processing and maturation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Shizhen Chen, Long Xiao, Yu Li, Maosong Qiu, Yaping Yuan, Rui Zhou, Conggang Li, Lei Zhang, Zhong-Xing Jiang, Maili Liu, Xin Zhou
Summary: FCy7-NO2, a novel dual-mode NIR fluorescence and F-19 MRI agent, is proposed for imaging tumor hypoxia, showing rapid monitoring of nitroreductase in tumors and sensitive detection over a broad concentration range without limits to imaging depth by integrating two complementary imaging technologies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yong Woong Jun, Eddy Albarran, David L. Wilson, Jun Ding, Eric T. Kool
Summary: Mitochondrial function declines with aging and neurodegeneration, largely due to accumulated mutations in mtDNA from deficient DNA repair. A fluorescent probe, UBER, was used to visualize mitochondrial BER activity, showing increased repair under oxidative stress and time delay between stress onset and BER initiation. Cells lacking MTH1 exhibited elevated demand for BER activity during extended stress, while absence of OGG1 limited glycosylation capacity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu, Mridula K. Venkateswaran, James G. Davis, Karthik Ramachandran, Sukanthathulse Uthayabalan, Cristel Allen, Ayodeji Osidele, Kristen Stanley, Nicholas P. Bigham, Terry M. Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M. Imran Aslam, W. Brian Reeves, Brij B. Singh, Jeffrey Caplan, Justin J. Wilson, Peter B. Stathopulos, Joseph A. Baur, Muniswamy Madesh
Summary: In mice consuming a Western diet, genetic ablation of the mitochondrial Mg2+ channel Mrs2 prevents weight gain and promotes metabolism, leading to decreased fat accumulation in the liver and browning of white adipose. Mrs2 deficiency restrains citrate efflux from the mitochondria, making it unavailable to support de novo lipogenesis. Lowering mMg2+ promotes metabolism and dampens diet-induced obesity and metabolic syndrome.
Review
Dentistry, Oral Surgery & Medicine
Y. Xu, X. Deng, Y. Sun, X. Wang, Y. Xiao, Y. Li, Q. Chen, L. Jiang
Summary: Oral potentially malignant disorders (OPMDs) are a group of oral lesions that have a variable risk of transforming into oral cancer. Traditional oral examinations may miss early malignant lesions, but optical techniques offer noninvasive methods for detecting these changes. This article provides a comprehensive review of various optical imaging methods used in the diagnosis of OPMDs, discussing their advantages, limitations, and future challenges.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Cell Biology
Igor Kukhtevich, Mariana Rivero-Romano, Namisha Rakesh, Poonam Bheda, Yagya Chadha, Paulina Rosales-Becerra, Stephan Hamperl, Daniela Bureik, Scarlett Dornauer, Catherine Dargemont, Antonis Kirmizis, Kurt M. Schmoller, Robert Schneider
Summary: RNA distribution during cell division is asymmetric and regulated by factors such as the lifespan regulator Sir2 and replicative age. This study establishes an approach to quantify RNA dynamics in single cells using the diSpinach aptamer in a microfluidics device and validates it using budding yeast as a model.
Article
Cell Biology
Dingan Luo, Youpeng Wang, Mao Zhang, Haoran Li, Deze Zhao, Hui Li, Xiaowu Chen, Cheng Jin, Bing Han
Summary: The Pringle maneuver (PM) used during hepatocellular carcinoma (HCC) resection can lead to tumor metastasis due to ischemia and hypoxia. This study discovered that high expression of suppressor of cytokine signaling 5 (SOCS5) significantly affected the prognosis of HCC patients undergoing long-time PM. The study also showed that SOCS5 promotes the expression of hypoxia-inducible factor 1 subunit alpha (HIF-1 alpha) protein, which is associated with higher hypoxia scores. Knockdown of SOCS5 inhibited HCC cell invasion and migration through the PI3K/Akt/mTOR/HIF-1 alpha signaling axis. This research highlights the potential of a SOCS5-specific inhibitor to control PM-induced tumor micrometastases during HCC resection.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Pavel E. Z. Klier, Julia G. Martin, Evan W. Miller
Summary: A novel fluorescent Delta Psi(m) reporter, SPIRIT RhoVR, has been developed that targets mitochondria without the need for Delta Psi(m)-dependent accumulation, enabling reversible reporting on changes in Delta Psi(m). SPIRIT RhoVR responds rapidly and accurately to changes in Delta Psi(m) induced by low concentrations of uncoupler across different cell lines, showing good compatibility for multi-color imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Cell Biology
Cory L. Simpson, Mariko K. Tokito, Ranjitha Uppala, Mrinal K. Sarkar, Johann E. Gudjonsson, Erika L. F. Holzbaur
Summary: This study reveals that regulated breakdown of mitochondria is critical for epidermal development, with keratinocytes in the upper layers initiating mitochondrial fragmentation, depolarization, and acidification. The mitophagy receptor NIX and DRP1 play essential roles in driving epidermal morphogenesis by promoting mitochondrial degradation in the terminal differentiation of keratinocytes.
Article
Oncology
Roberta Fusco, Vincenza Granata, Mauro Mattace Raso, Paolo Vallone, Alessandro Pasquale De Rosa, Claudio Siani, Maurizio Di Bonito, Antonella Petrillo, Mario Sansone
Summary: The study aimed to differentiate benign and malignant breast lesions by combining BOLD-MRI, DCE-MRI, and DW-MRI, but found that the combined use of these imaging techniques did not provide a significant improvement compared to using DCE-MRI alone. An interesting result was the negative correlation between R-2* and D.
Article
Chemistry, Analytical
Hongyang Xie, Qisheng Li, Huiwen Yang, Weijie Gao, Qian Zhang, Peng Zhang, Caifeng Ding
Summary: This study proposes a near infrared fluorescent probe Q-NTR, which is activated by NTR in mitochondria, to evaluate the degree of hypoxia in tumor tissues. It provides a practical tool for studying NTR activity and hypoxia related biological processes with its subcellular structure level imaging and rapid response characteristics.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Dermatology
Chloe J. Chua, Prabodh K. Pandey, Kristen M. Kelly, Liangzhong Xiang
Summary: This study investigates the feasibility of a hybrid treatment modality for port wine birthmark, combining photoacoustic (PA) guided ultrasound (US) focusing. The proposed methodology allows for selective targeting of the vasculature while minimizing damage to neighboring tissue.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Dermatology
Ina Ly, Carlos G. Romo, Sally Gottesman, Kristen M. Kelly, Deanna Kornacki, Zachary York, Sang Y. Lee, Steven D. Rhodes, Verena Staedtke, Matthew R. Steensma, Jaishri O. Blakeley, Pierre Wolkenstein
Summary: Cutaneous neurofibromas (cNFs) are benign tumors of the skin that have a significant impact on quality of life. Current treatment options are limited to surgery or laser-based treatments, but these have mixed success and cannot be easily applied to a large number of tumors.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Yingjoy Li, Jaishri O. Blakeley, Ina Ly, Yemima Berman, Jonathan Lau, Pierre Wolkenstein, Christina Bergqvist, Wangcun Jia, Thomas E. Milner, Nitesh Katta, Anthony J. Durkin, Gordon T. Kennedy, Rebecca Rowland, Carlos G. Romo, Jane Fleming, Kristen M. Kelly
Summary: A consistent set of measurement techniques must be applied to evaluate the efficacy of treatments for cutaneous neurofibromas (cNFs) in people with neurofibromatosis type 1 (NF1). This review discusses various approaches used or developed to identify, measure, and track cNFs, including calipers, digital imaging, and high-frequency ultrasound sonography. Emerging technologies such as spatial frequency domain imaging and optical coherence tomography may enable early detection of cNFs and prevention of tumor-associated morbidity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Jaishri O. Blakeley, Lu Q. Le, Sang Y. Lee, Ina Ly, Steven D. Rhodes, Carlos G. Romo, Kavita Y. Sarin, Verena Staedtke, Matthew R. Steensma, Pierre Wolkenstein
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Md Abdullah Shamim, Ayaz Shahid, Pabitra K. Sardar, Steven Yeung, Jeremiah Reyes, Jenny Kim, Cyrus Parsa, Robert Orlando, Jeffrey Wang, Kristen M. Kelly, Frank L. Meyskens, Bradley T. Andresen, Ying Huang
Summary: The R-carvedilol enantiomer, which does not bind to beta-adrenergic receptors, exhibits skin cancer preventive activity. Transfersomes loaded with R-carvedilol were prepared and characterized. These transfersomes showed slower drug release but significantly enhanced skin drug permeation and retention compared to the free drug.
Review
Oncology
Ruby Tow, Samuel Hanoun, Bradley Andresen, Ayaz Shahid, Jeffrey Wang, Kristen M. Kelly, Frank L. L. Meyskens Jr, Ying Huang
Summary: Skin cancer is the most common cancer type in the United States and the world. Chemoprevention is an appealing strategy to control the increasing rate of skin cancer. The present review outlines the current state of skin cancer chemoprevention clinical trials, including study populations, agents, outcomes, predictive biomarkers, and adverse reactions.
Meeting Abstract
Dermatology
Rachel Elsanadi, Kristen Kelly
LASERS IN SURGERY AND MEDICINE
(2023)
Meeting Abstract
Dermatology
Rachel Elsanadi, Aditi Sharma, Patrick Lee, Jalal Maghfour, John Soliman, Erica Baugh, Solomiya Grushchak, Anna-Marie Hosking, Linda Doan, Indermeet Kohli, Kaitlyn Jones, David Ozog, Kristen Kelly, John Wuennenberg, Christopher Zachary
LASERS IN SURGERY AND MEDICINE
(2023)
Meeting Abstract
Dermatology
Wangcun Jia, Gordon Kennedy, Nitesh Katta, Junsoo Lee, Rachel Elsanadi, Emily Nguyen, Anat Stemmer-Rachamimov, J. Stuart Nelson, Rafael Sierra, Kristen Kelly, Anthony Durkin, Thomas Milner
LASERS IN SURGERY AND MEDICINE
(2023)
Meeting Abstract
Dermatology
Jalal Maghfour, Rachel Elsanadi, Brittany Lane, John Wuennenberg, Erica Baugh, John Soliman, Anna-Marie Hosking, Indermeet Kohli, Chris Robb, Kristen Kelly, Christopher Zachary, David Ozog
LASERS IN SURGERY AND MEDICINE
(2023)
Meeting Abstract
Dermatology
Katerina Yale, Surget Cox, Solomiya Grushchak, Patrick Lee, Kristen Kelly
LASERS IN SURGERY AND MEDICINE
(2023)
Meeting Abstract
Dermatology
Christopher Zachary, Kristen Kelly, Rachel Elsanadi, Indermeet Kohli, Linda Doan, Jalal Machfour, John Soliman, Solomiya Grushchak, Anna-Marie Hosk-Ing, John Wuennenberg, Erica Baugh, David Ozog
LASERS IN SURGERY AND MEDICINE
(2023)
Proceedings Paper
Dermatology
Christopher B. Zachary, Rachel Elsanadi, Jalal Maghfour, Indermeet Kohli, Kristen M. Kelly, Rachana Soni, Craig Fortier, Jon Holmes, Hachi Heckt, Alexander Makowski, Dan Negus, Linda Doan, Anna-Marie Hosking, Solomiya Grushchak, John Soliman, John Wuenneberg, Joe Mehrabi, Erica Baugh, Chris Robb, David Ozog
Summary: Heating has been used to treat cancer for a long time, and recent studies have confirmed its effectiveness in treating basal cell carcinomas (BCC). The use of a forward looking infrared (FLIR) camera and a modulated long pulsed (LP) Nd:YAG 1064nm laser has improved the outcomes compared to traditional techniques. Optical coherence tomography (OCT) helps to define tumor margins before treatment, and when combined with FLIR, it allows for precise treatment of BCCs with outcomes comparable to conventional LP Nd:YAG treatments.
PHOTONICS IN DERMATOLOGY AND PLASTIC SURGERY 2023
(2023)
Article
Dermatology
Kira Minkis, Diana Bolotin, M. Laurin Council, Anna Bar, Ronda S. Farah, Nour Kibbi, Rachel Y. N. Miest, Jeffrey S. Orringer, Arisa Ortiz, Kathleen C. Suozzi, Neelam A. Vashi, Simon S. Yoo, Joerg Albrecht, Travis W. Blalock, Alison J. Bruce, Min Deng, Shraddha Desai, Milad Eshaq, Lori A. Fiessinger, Erica Ghareeb, Tanya Greywal, Adelaide A. Hebert, Deirdre Hooper, Maria Hordinsky, Jenny C. Hu, Atieh Jibbe, Jayne Joo, Kristen M. Kelly, Sonya Kenkare, Shilpi Khetarpal, Lauren C. S. Kole, A. Shadi Kourosh, Helena Kuhn, Kachiu C. Lee, Roberta Lucas, Janiene Luke, Mariam Mafee, Tiffany T. Mayo, Zeena Y. Nawas, Edit B. Olasz Harken, Michelle Pearlstein, Vesna Petronic-Rosic, Carolyn A. Robinson, Megan N. Rogge, Sami K. Saikaly, Olivia L. Schenck, Cynthia A. Schlick, Ladan Shahabi, Desmond M. Shipp, Melissa Shive, Sirunya Silapunt, Erik J. Stratman, Ronald Sulewski, Amanda K. Suggs, Leila Tolaymat, Kimberley H. M. Ward, Mara Weinstein Velez, Joshua Zeichner, Bianca Y. Kang, Sarah A. Ibrahim, Rachel E. Christensen, Noor Anvery, McKenzie A. Dirr, Naomi Lawrence, Murad Alam
Summary: Cosmetic dermatology is a key subspecialty of academic dermatology, and academic centers are expected to excel in teaching skills, delivering services, and conducting clinical research in this field. The Association of Academic Cosmetic Dermatology (AACD) was created to support these areas and consists of board-certified dermatologists who already teach cosmetic and laser dermatology. Recently, an expert panel convened by AACD reviewed gaps in academic cosmetic dermatology and developed a roadmap to address these issues.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Kira Minkis, Diana Bolotin, M. Laurin Council, Anna Bar, Ronda S. Farah, Nour Kibbi, Rachel Y. N. Miest, Jeffrey S. Orringer, Arisa Ortiz, Kathleen C. Suozzi, Neelam A. Vashi, Simon S. Yoo, Joerg Albrecht, Travis W. Blalock, Alison J. Bruce, Min Deng, Shraddha Desai, Milad Eshaq, Lori A. Fiessinger, Erica Ghareeb, Tanya Greywal, Adelaide A. Hebert, Deirdre Hooper, Maria Hordinsky, Jenny C. Hu, Atieh Jibbe, Jayne Joo, Kristen M. Kelly, Sonya Kenkare, Shilpi Khetarpal, Lauren C. S. Kole, A. Shadi Kourosh, Helena Kuhn, Kachiu C. Lee, Roberta Lucas, Janiene Luke, Mariam Mafee, Tiffany T. Mayo, Zeena Y. Nawas, Edit B. Olasz Harken, Michelle Pearlstein, Vesna Petronic-Rosic, Carolyn A. Robinson, Megan N. Rogge, Dana L. Sachs, Sami K. Saikaly, Olivia L. Schenck, Cynthia A. Schlick, Ladan Shahabi, Desmond M. Shipp, Melissa Shive, Sirunya Silapunt, Amanda K. Suggs, Leila Tolaymat, Kimberley H. M. Ward, Mara Weinstein Velez, Joshua Zeichner, Bianca Y. Kang, Sarah A. Ibrahim, Rachel E. Christensen, Noor Anvery, McKenzie A. Dirr, Naomi Lawrence, Murad Alam
Summary: Cosmetic and laser procedures are popular among patients and dermatologists are well trained in these skills. Most dermatology residents want to incorporate cosmetic procedures into their practice and prefer to learn them during residency. However, there are challenges in how residents are trained in cosmetic and laser dermatology. To address these barriers, the Association of Academic Cosmetic Dermatology (AACD) was founded in 2021 as a professional society for dermatologists who educate resident trainees in cosmetic and laser dermatology. The AACD aims to improve cosmetic dermatology education through collaboration, research, and advocacy.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)