The immune system and psychiatric disease: a basic science perspective

Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment

(2019) Geoffrey N. Pronovost et al.   IMMUNITY

Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

(2019) Jonathan W. VanRyzin et al.   NEURON

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

(2019) Xiaoyu Liu et al.   IMMUNITY

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux

(2018) Shirley L. Zhang et al.   CELL

Why Innate Lymphoid Cells?

(2018) Maya E. Kotas et al.   IMMUNITY

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

(2018) James C. Cronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

(2018) Harald Lund et al.   NATURE IMMUNOLOGY

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1

(2018) Charise Garber et al.   NATURE IMMUNOLOGY

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement

(2018) Lucas Cheadle et al.   NEURON

β2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses

(2018) Saya Moriyama et al.   SCIENCE

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

(2018) Vidya Narayanaswami et al.   Molecular Imaging

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

(2018) Anat Shemer et al.   Nature Communications

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

(2017) Changchun Chen et al.   NATURE

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

(2017) Sangdoo Kim et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

High-dimensional, single-cell characterization of the brain's immune compartment

(2017) Ben Korin et al.   NATURE NEUROSCIENCE

Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

(2017) Grietje Krabbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

(2016) Andrew Wang et al.   CELL

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury

(2016) Sachin P. Gadani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

(2016) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

(2016) Dorothy P Schafer et al.   eLife

Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance

(2016) S Monteiro et al.   Translational Psychiatry

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

(2015) Yuriy Pomeshchik et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response

(2015) Yi Luo et al.   BRAIN RESEARCH

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Autism spectrum disorders: from genes to neurobiology

(2015) A Jeremy Willsey et al.   CURRENT OPINION IN NEUROBIOLOGY

The 3 major types of innate and adaptive cell-mediated effector immunity

(2015) Francesco Annunziato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Homeostatic interferon expression in neurons is sufficient for early control of viral infection

(2015) Sarah E. Cavanaugh et al.   JOURNAL OF NEUROIMMUNOLOGY

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types

(2015) X. Liu et al.   JOURNAL OF NEUROSCIENCE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling

(2014) Anna Dellarole et al.   BRAIN BEHAVIOR AND IMMUNITY

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

(2014) A Masi et al.   MOLECULAR PSYCHIATRY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma

(2014) Raquel C. Gardner et al.   JAMA Neurology

Suicide, Fatal Injuries, and Other Causes of Premature Mortality in Patients With Traumatic Brain Injury

(2014) Seena Fazel et al.   JAMA Psychiatry

Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis

(2013) Zhiguo Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

TAM Receptors Affect Adult Brain Neurogenesis by Negative Regulation of Microglial Cell Activation

(2013) R. Ji et al.   JOURNAL OF IMMUNOLOGY

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory

(2013) Bingfang Liu et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging

(2012) Aoife O’Donovan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Major histocompatibility complex class I proteins in brain development and plasticity

(2012) Bradford M. Elmer et al.   TRENDS IN NEUROSCIENCES

Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies

(2012) A Vita et al.   Translational Psychiatry

Autoimmune Diseases and Severe Infections as Risk Factors for Schizophrenia: A 30-Year Population-Based Register Study

(2011) Michael E. Benros et al.   AMERICAN JOURNAL OF PSYCHIATRY

Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects

(2011) Brian J. Miller et al.   BIOLOGICAL PSYCHIATRY

The role of immune dysfunction in the pathophysiology of autism

(2011) Charity Onore et al.   BRAIN BEHAVIOR AND IMMUNITY

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Is Traumatic Brain Injury A Risk Factor for Schizophrenia? A Meta-Analysis of Case-Controlled Population-Based Studies

(2011) C. Molloy et al.   SCHIZOPHRENIA BULLETIN

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Cytokine, Sickness Behavior, and Depression

(2009) Robert Dantzer   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Cognitive dysfunction in mice deficient for TNF- and its receptors

(2008) Bernhard T. Baune et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Role of Regulatory and Proinflammatory T-Cell Populations in Allergic Diseases

(2008) Kanami Orihara et al.   World Allergy Organization Journal

Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review

(2007) Stéphane Potvin et al.   BIOLOGICAL PSYCHIATRY