Structure Elucidation of Helical Aromatic Foldamer–Protein Complexes with Large Contact Surface Areas

Peptidomimetic-Based Multidomain Targeting Offers Critical Evaluation of Aβ Structure and Toxic Function

(2018) Sunil Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA

(2018) Krzysztof Ziach et al.   Nature Chemistry

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

(2018) Daniel A Keedy et al.   eLife

Auto-regulated Protein Assembly on a Supramolecular Scaffold

(2018) Martin L. Rennie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhancing Aromatic Foldamer Helix Dynamics to Probe Interactions with Protein Surfaces

(2018) Maelle Vallade et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Assessing Interactions between Helical Aromatic Oligoamide Foldamers and Protein Surfaces: A Tethering Approach

(2018) Maëlle Vallade et al.   BIOCONJUGATE CHEMISTRY

Foldamer-Mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity

(2017) Sunil Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Helix Mimetics as Modulators of Aβ Self-Assembly

(2017) Sunil Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein–Protein Interface

(2017) David Bier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Assembled Protein–Aromatic Foldamer Complexes with 2:3 and 2:2:1 Stoichiometries

(2017) Michal Jewginski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Designing cooperatively folded abiotic uni- and multimolecular helix bundles

(2017) Soumen De et al.   Nature Chemistry

Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions

(2017) Bing Yang et al.   Nature Communications

“Sticky”-Ends-Guided Creation of Functional Hollow Nanopores for Guest Encapsulation and Water Transport

(2016) Yanping Huo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biomimetic Transmembrane Channels with High Stability and Transporting Efficiency from Helically Folded Macromolecules

(2016) Chao Lang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State

(2016) Pradeep K. Mandal et al.   CHEMBIOCHEM

Solution Observation of Dimerization and Helix Handedness Induction in a Human Carbonic Anhydrase-Helical Aromatic Amide Foldamer Complex

(2016) Michal Jewginski et al.   CHEMBIOCHEM

Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin

(2016) Sunil Kumar et al.   CHEMICAL COMMUNICATIONS

Solid-Phase Synthesis of Water-Soluble Helically Folded Hybrid α-Amino Acid/Quinoline Oligoamides

(2016) Xiaobo Hu et al.   JOURNAL OF ORGANIC CHEMISTRY

Persistent Organic Nanopores Amenable to Structural and Functional Tuning

(2016) Xiaoxi Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aptamers: The “evolution” of SELEX

(2016) Yi Xi Wu et al.   METHODS

Foldamer-mediated manipulation of a pre-amyloid toxin

(2016) Sunil Kumar et al.   Nature Communications

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions

(2015) Anna Barnard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain

(2015) Chunyan Ren et al.   CHEMISTRY & BIOLOGY

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers

(2015) Valeria Azzarito et al.   Chemical Science

Structural study of a small molecule receptor bound to dimethyllysine in lysozyme

(2015) Róise E. McGovern et al.   Chemical Science

Targeting DNA G-Quadruplexes with Helical Small Molecules

(2014) Sebastian Müller et al.   CHEMBIOCHEM

Protein assembly mediated by sulfonatocalix[4]arene

(2014) Róise E. McGovern et al.   CHEMICAL COMMUNICATIONS

Folded Small Molecule Manipulation of Islet Amyloid Polypeptide

(2014) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

Hydrogen-Bonded Helical Hydrazide Oligomers and Polymer That Mimic the Ion Transport of Gramicidin A

(2014) Pengyang Xin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a Complex Formed by a Protein and a Helical Aromatic Oligoamide Foldamer at 2.1 Å Resolution

(2013) Jérémie Buratto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

(2013) Sunil Kumar et al.   CHEMICAL COMMUNICATIONS

Solid-Phase Methodology for Synthesis ofO-Alkylated Aromatic Oligoamide Inhibitors of α-Helix-Mediated Protein-Protein Interactions

(2013) Natasha S. Murphy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Characterization of suramin binding sites on the human group IIA secreted phospholipase A2 by site-directed mutagenesis and molecular dynamics simulation

(2012) Elisângela Aparecida Aragão et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Solvent dependence of helix stability in aromatic oligoamide foldamers

(2012) Ting Qi et al.   CHEMICAL COMMUNICATIONS

Aromatic Amide Foldamers: Structures, Properties, and Functions

(2012) Dan-Wei Zhang et al.   CHEMICAL REVIEWS

Protein camouflage in cytochrome c–calixarene complexes

(2012) Róise E. McGovern et al.   Nature Chemistry

Deciphering Aromatic Oligoamide Foldamer-DNA Interactions

(2011) Laurence Delaurière et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polypeptide Conjugate Binders that Discriminate between Two Isoforms of Human Carbonic Anhydrase in Human Blood

(2011) Lotta T. Tegler et al.   CHEMBIOCHEM

Identification of Specific Tethered Inhibitors for Caspase-5

(2011) Junjun Gao et al.   Chemical Biology & Drug Design

The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site

(2011) Hugh P. Morgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An improved strategy for the crystallization ofLeishmania mexicanapyruvate kinase

(2010) Hugh P. Morgan et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Absolute Control of Helical Handedness in Quinoline Oligoamides

(2010) Amol M. Kendhale et al.   JOURNAL OF ORGANIC CHEMISTRY

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases

(2009) Luis Maurício T.R. Lima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

De novo designed synthetic mimics of antimicrobial peptides

(2008) Richard W Scott et al.   CURRENT OPINION IN BIOTECHNOLOGY