Solution Observation of Dimerization and Helix Handedness Induction in a Human Carbonic Anhydrase-Helical Aromatic Amide Foldamer Complex

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions

(2015) Anna Barnard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics

(2015) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies

(2015) Céline Gloaguen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein–Protein Interactions Mediated by Helical Tertiary Structure Motifs

(2015) Andrew M. Watkins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose

(2015) Nagula Chandramouli et al.   Nature Chemistry

Multivalent helix mimetics for PPI-inhibition

(2015) Anna Barnard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold

(2015) James W. Checco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation

(2015) Oleg V. Kulikov et al.   TETRAHEDRON LETTERS

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers

(2015) Valeria Azzarito et al.   Chemical Science

A Multifaceted Secondary Structure Mimic Based On Piperidine-piperidinones

(2014) Dongyue Xin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting DNA G-Quadruplexes with Helical Small Molecules

(2014) Sebastian Müller et al.   CHEMBIOCHEM

Small-Molecule Proteomimetic Inhibitors of the HIF-1α-p300 Protein-Protein Interaction

(2014) George M. Burslem et al.   CHEMBIOCHEM

Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates

(2014) Rhys Dylan Taylor et al.   Chemistry-An Asian Journal

Controlling Helix Handedness in Water-Soluble Quinoline Oligoamide Foldamers

(2014) Simon J. Dawson et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo

(2014) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a Complex Formed by a Protein and a Helical Aromatic Oligoamide Foldamer at 2.1 Å Resolution

(2013) Jérémie Buratto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

(2013) Sunil Kumar et al.   CHEMICAL COMMUNICATIONS

Chemical Development of Intracellular Protein Heterodimerizers

(2013) Dominik Erhart et al.   CHEMISTRY & BIOLOGY

Solid-Phase Methodology for Synthesis ofO-Alkylated Aromatic Oligoamide Inhibitors of α-Helix-Mediated Protein-Protein Interactions

(2013) Natasha S. Murphy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS)

(2013) Dongyue Xin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR)

(2013) W. Edward Martucci et al.   MedChemComm

Solvent dependence of helix stability in aromatic oligoamide foldamers

(2012) Ting Qi et al.   CHEMICAL COMMUNICATIONS

Aromatic Amide Foldamers: Structures, Properties, and Functions

(2012) Dan-Wei Zhang et al.   CHEMICAL REVIEWS

2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

(2012) Valeria Azzarito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aromatic garlands, as new foldamers, to mimic protein secondary structure

(2012) Anne Sophie Voisin-Chiret et al.   TETRAHEDRON

Synthesis of the novel trimeric benzamides—potential inhibitors of protein–protein interactions

(2012) Oleg V. Kulikov et al.   RSC Advances

Deciphering Aromatic Oligoamide Foldamer-DNA Interactions

(2011) Laurence Delaurière et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polypeptide Conjugate Binders that Discriminate between Two Isoforms of Human Carbonic Anhydrase in Human Blood

(2011) Lotta T. Tegler et al.   CHEMBIOCHEM

Synthetic foldamers

(2011) Gilles Guichard et al.   CHEMICAL COMMUNICATIONS

Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

(2011) Arjun Raghuraman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Relative Helix−Helix Conformations in Branched Aromatic Oligoamide Foldamers

(2011) Nicolas Delsuc et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

(2011) Melissa D. Boersma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemically Controlled Protein Assembly: Techniques and Applications

(2010) Adrian Fegan et al.   CHEMICAL REVIEWS

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

(2010) Aslamuzzaman Kazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid Phase Synthesis of Aromatic Oligoamides: Application to Helical Water-Soluble Foldamers

(2010) Benoît Baptiste et al.   JOURNAL OF ORGANIC CHEMISTRY

Absolute Control of Helical Handedness in Quinoline Oligoamides

(2010) Amol M. Kendhale et al.   JOURNAL OF ORGANIC CHEMISTRY

N-alkylated oligoamide α-helical proteomimetics

(2010) Frederick Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

(2009) Erinna F. Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-Permeable β-Peptide Inhibitors of p53/hDM2 Complexation

(2009) Elizabeth A. Harker et al.   CHEMBIOCHEM

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction

(2009) Jeffrey P. Plante et al.   CHEMICAL COMMUNICATIONS

A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes

(2009) James A. Hebda et al.   CHEMISTRY & BIOLOGY

Structure and Function of Benzoylurea-Derived α-Helix Mimetics Targeting the Bcl-xL/Bak Binding Interface

(2009) Johanna M. Rodriguez et al.   ChemMedChem

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

(2009) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers

(2008) Nicolas Delsuc et al.   CHEMPHYSCHEM

Synthesis and Biological Evaluation of a 5-6-5 Imidazole-Phenyl-Thiazole Based α-Helix Mimetic

(2008) Christopher G. Cummings et al.   ORGANIC LETTERS