Emerging concepts in the pathogenesis of the Streptococcus pneumoniae : From nasopharyngeal colonizer to intracellular pathogen

Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses

(2018) Mario Codemo et al.   mBio

Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking

(2018) Manalee Vishnu Surve et al.   PLoS Pathogens

Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15

(2018) Brian Wahl et al.   Lancet Global Health

Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia

(2018) Giuseppe Ercoli et al.   Nature Microbiology

Pathogenesis and Prevention of Risk of Cardiovascular Events in Patients with Pneumococcal Community-acquired Pneumonia

(2018) Charles Feldman et al.   JOURNAL OF INTERNAL MEDICINE

Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination

(2018) Germaine Hanquet et al.   THORAX

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

(2018) Karthik Subramanian et al.   Nature Microbiology

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion

(2017) Federico Iovino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing

(2017) Anukul T. Shenoy et al.   PLoS Pathogens

A dynamic relationship between mucosal T helper type 17 and regulatory T-cell populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans

(2016) A. Mubarak et al.   CLINICAL MICROBIOLOGY AND INFECTION

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden

(2016) Ilias Galanis et al.   EUROPEAN RESPIRATORY JOURNAL

Diverse Ecological Strategies Are Encoded byStreptococcus pneumoniaeBacteriocin-Like Peptides

(2016) Eric L. Miller et al.   Genome Biology and Evolution

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion

(2016) Ryan P. Gilley et al.   INFECTION AND IMMUNITY

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA

(2016) Federico Iovino et al.   JOURNAL OF CLINICAL INVESTIGATION

How Does Streptococcus pneumoniae Invade the Brain?

(2016) Federico Iovino et al.   TRENDS IN MICROBIOLOGY

Unaltered pneumococcal carriage prevalence due to expansion of non-vaccine types of low invasive potential 8 years after vaccine introduction in Stockholm, Sweden

(2016) Ann Lindstrand et al.   VACCINE

Pneumococcal meningitis: Clinical-pathological correlations (meningene-path)

(2016) Joo-Yeon Engelen-Lee et al.   Acta Neuropathologica Communications

Genomic analyses of pneumococci reveal a wide diversity of bacteriocins – including pneumocyclicin, a novel circular bacteriocin

(2015) Carlijn Bogaardt et al.   BMC GENOMICS

Pneumococcal Capsules and Their Types: Past, Present, and Future

(2015) K. Aaron Geno et al.   CLINICAL MICROBIOLOGY REVIEWS

Identification of a Monoclonal Antibody Against Pneumococcal Pilus 1 Ancillary Protein Impairing Bacterial Adhesion to Human Epithelial Cells

(2015) Fulvia Amerighi et al.   JOURNAL OF INFECTIOUS DISEASES

Density and Duration of Pneumococcal Carriage Is Maintained by Transforming Growth Factor β1 and T Regulatory Cells

(2014) Daniel R. Neill et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus

(2014) Yung-Chi Chang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Antibody blocks acquisition of bacterial colonization through agglutination

(2014) A M Roche et al.   Mucosal Immunology

The co-pathogenesis of influenza viruses with bacteria in the lung

(2014) Jonathan A. McCullers   NATURE REVIEWS MICROBIOLOGY

Streptococcus pneumoniae Interacts with pIgR Expressed by the Brain Microvascular Endothelium but Does Not Co-Localize with PAF Receptor

(2014) Federico Iovino et al.   PLoS One

Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function

(2014) Armand O. Brown et al.   PLoS Pathogens

Enhanced, Sialoadhesin-Dependent Uptake of Guillain-Barré Syndrome-Associated Campylobacter jejuni Strains by Human Macrophages

(2013) Astrid P. Heikema et al.   INFECTION AND IMMUNITY

Porcine, murine and human sialoadhesin (Sn/Siglec-1/CD169): portals for porcine reproductive and respiratory syndrome virus entry into target cells

(2013) W. Van Breedam et al.   JOURNAL OF GENERAL VIROLOGY

AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis inStreptococcus pneumoniae

(2013) Charles D. Plumptre et al.   MOLECULAR MICROBIOLOGY

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms

(2013) J. R. Shak et al.   mBio

Cardiac Complications in Patients With Community-Acquired Pneumonia

(2012) Vicente F. Corrales-Medina et al.   CIRCULATION

Sialoadhesin Promotes Rapid Proinflammatory and Type I IFN Responses to a Sialylated Pathogen, Campylobacter jejuni

(2012) M. Klaas et al.   JOURNAL OF IMMUNOLOGY

Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease

(2012) S. Orrskog et al.   mBio

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

(2011) Shigeki Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

BgaA acts as an adhesin to mediate attachment of some pneumococcal strains to human epithelial cells

(2011) D. H. Limoli et al.   MICROBIOLOGY-SGM

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

(2011) Nadine Honke et al.   NATURE IMMUNOLOGY

PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections

(2010) Inga Jensch et al.   MOLECULAR MICROBIOLOGY

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Streptococcus pneumoniaeevades human dendritic cell surveillance by pneumolysin expression

(2009) Marie Littmann et al.   EMBO Molecular Medicine

The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms

(2009) C. Hyams et al.   INFECTION AND IMMUNITY

Pneumolysin Localizes to the Cell Wall of Streptococcus pneumoniae

(2009) K. E. Price et al.   JOURNAL OF BACTERIOLOGY

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

(2009) Satoshi Uchiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner

(2009) L. E. Cron et al.   MICROBIOLOGY-SGM

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae

(2008) Kimberly M. Davis et al.   PLoS Pathogens