Increased translation as a novel pathogenic mechanism in Huntington’s disease

Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration

(2018) Jordi Creus-Muncunill et al.   MOLECULAR NEUROBIOLOGY

Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease

(2017) Anna Parievsky et al.   NEUROBIOLOGY OF DISEASE

Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo

(2017) Barbara Y. Braz et al.   NEUROPHARMACOLOGY

Huntington’s Disease and Mitochondria

(2017) Mohammad Jodeiri Farshbaf et al.   NEUROTOXICITY RESEARCH

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Metformin intake associates with better cognitive function in patients with Huntington's disease

(2017) David Hervás et al.   PLoS One

GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

(2016) Hiromi Ito et al.   BMC CANCER

Requirement of Neuronal Ribosome Synthesis for Growth and Maintenance of the Dendritic Tree

(2016) Lukasz P. Slomnicki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mouse cortico-striatal projectome

(2016) Houri Hintiryan et al.   NATURE NEUROSCIENCE

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity

(2016) Marta Anglada-Huguet et al.   NEUROBIOLOGY OF DISEASE

Impaired development of cortico-striatal synaptic connectivity in a cell culture model of Huntington's disease

(2016) Caodu Buren et al.   NEUROBIOLOGY OF DISEASE

Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics

(2016) Jing Jin et al.   NEUROMOLECULAR MEDICINE

Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis

(2016) J Musa et al.   ONCOGENE

Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis

(2015) Thomas W. Gardner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

(2015) Rafael P. Vázquez-Manrique et al.   HUMAN MOLECULAR GENETICS

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease

(2015) Marta Fernández-Nogales et al.   HUMAN MOLECULAR GENETICS

A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease

(2015) Mar Puigdellívol et al.   HUMAN MOLECULAR GENETICS

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTRup-regulation and astrocyte-mediated inflammation

(2015) Andrés Miguez et al.   HUMAN MOLECULAR GENETICS

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease

(2015) Shiraz Tyebji et al.   NEUROBIOLOGY OF DISEASE

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6/1 model of Huntington’s disease

(2015) E.A.F. Herbst et al.   NEUROSCIENCE

Compensatory mechanisms in genetic models of neurodegeneration: are the mice better than humans?

(2015) Grzegorz Kreiner   Frontiers in Cellular Neuroscience

Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients

(2015) A Topol et al.   Translational Psychiatry

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

(2014) Ian Martin et al.   CELL

Abberant protein synthesis in G2019S LRRK2DrosophilaParkinson disease-related phenotypes

(2014) Ian Martin et al.   FLY

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain

(2014) N. K. H. Lim et al.   HUMAN MOLECULAR GENETICS

Genome-wide identification and quantification of protein synthesis in cultured cells and whole tissues by puromycin-associated nascent chain proteomics (PUNCH-P)

(2014) Ranen Aviner et al.   Nature Protocols

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

(2014) Jun-Shiao Chou et al.   NEUROBIOLOGY OF DISEASE

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Inhibition of protein translation as a novel mechanism for prostaglandin E2 regulation of cell functions

(2013) Katsuhide Okunishi et al.   FASEB JOURNAL

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease

(2013) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

Proteasomal Degradation of Eukaryotic Elongation Factor-2 Kinase (EF2K) Is Regulated by cAMP-PKA Signaling and the SCFβTRCPUbiquitin E3 Ligase

(2013) Shari L. Wiseman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease

(2013) Laura Rué et al.   NEUROBIOLOGY OF DISEASE

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Observational learning in mice can be prevented by medial prefrontal cortex stimulation and enhanced by nucleus accumbens stimulation

(2012) M. T. Jurado-Parras et al.   LEARNING & MEMORY

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: 13C NMR and magnetic resonance imaging studies in AD models

(2012) Norah Algarzae et al.   NEUROSCIENCE

PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1

(2012) Chong Kiat Goo et al.   PLoS One

An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice

(2011) Mai T. Dang et al.   BEHAVIOURAL BRAIN RESEARCH

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (4EBP-1) Function Is Suppressed by Src and Protein Phosphatase 2A (PP2A) on Extracellular Matrix

(2011) Richard Seonghun Nho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactivating PP2A by FTY720 as a Novel therapy for AML with C-KIT tyrosine kinase domain mutation

(2011) Yan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity

(2011) A. Saavedra et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum

(2009) A Saavedra et al.   CELL DEATH AND DIFFERENTIATION

RhoE Inhibits 4E-BP1 Phosphorylation and eIF4E Function Impairing Cap-dependent Translation

(2009) Priam Villalonga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant huntingtin and glycogen synthase kinase 3-β accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease

(2009) Antonio Valencia et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Differing presynaptic contributions to LTP and associative learning in behaving mice

(2009) Neolia Madronal   Frontiers in Behavioral Neuroscience

AMPK represses TOP mRNA translation but not global protein synthesis in liver

(2008) Ali K. Reiter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CellProfiler Analyst: data exploration and analysis software for complex image-based screens

(2008) Thouis R Jones et al.   BMC BIOINFORMATICS

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid

(2008) Carme Pelegrí et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

(2008) M. A. King et al.   MOLECULAR PHARMACOLOGY