Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α- and γ-gliadin gene families

Development of the GlutEnSeq capture system for sequencing gluten gene families in hexaploid bread wheat with deletions or mutations induced by γ-irradiation or CRISPR/Cas9.

(2019) Aurélie Jouanin et al.   JOURNAL OF CEREAL SCIENCE

A PSTOL-like gene, TaPSTOL, controls a number of agronomically important traits in wheat

(2018) Matthew J. Milner et al.   BMC PLANT BIOLOGY

Food processing and breeding strategies for coeliac-safe and healthy wheat products

(2018) Aurélie Jouanin et al.   FOOD RESEARCH INTERNATIONAL

Next-generation therapies for celiac disease: The gluten-targeted approaches

(2018) Miguel Ribeiro et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Efficient generation of stable, heritable gene edits in wheat using CRISPR/Cas9

(2018) Rhian M Howells et al.   BMC PLANT BIOLOGY

Development of Wheat With Hypoimmunogenic Gluten Obstructed by the Gene Editing Policy in Europe

(2018) Aurélie Jouanin et al.   Frontiers in Plant Science

Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9

(2017) Susana Sánchez-León et al.   PLANT BIOTECHNOLOGY JOURNAL

High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9

(2017) Javier Gil-Humanes et al.   PLANT JOURNAL

Rapid evolutionary dynamics in a 2.8-Mb chromosomal region containing multiple prolamin and resistance gene families inAegilops tauschii

(2016) Lingli Dong et al.   PLANT JOURNAL

Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA

(2016) Yi Zhang et al.   Nature Communications

A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants

(2015) Xingliang Ma et al.   Molecular Plant

Coeliac disease and gluten-related disorders in childhood

(2015) Sabine L. Vriezinga et al.   Nature Reviews Gastroenterology & Hepatology

Creation of the first ultra-low gluten barley (Hordeum vulgareL.) for coeliac and gluten-intolerant populations

(2015) Gregory J. Tanner et al.   PLANT BIOTECHNOLOGY JOURNAL

Diversification of the celiac disease α-gliadin complex in wheat: a 33-mer peptide with six overlapping epitopes, evolved following polyploidization

(2015) Carmen V. Ozuna et al.   PLANT JOURNAL

Novel Approaches in Gluten-Free Breadmaking: Interface between Food Science, Nutrition, and Health

(2014) Vanessa D. Capriles et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Reducing the incidence of allergy and intolerance to cereals

(2014) Luud J.W.J. Gilissen et al.   JOURNAL OF CEREAL SCIENCE

The debate on coeliac disease screening—are we there yet?

(2014) Carlo Catassi et al.   Nature Reviews Gastroenterology & Hepatology

Yr36 Confers Partial Resistance at Temperatures Below 18°C to U.K. Isolates of Puccinia striiformis

(2014) Vanesa Segovia et al.   PHYTOPATHOLOGY

Multigene Knockout Utilizing Off-Target Mutations of the CRISPR/Cas9 System in Rice

(2014) Masaki Endo et al.   PLANT AND CELL PHYSIOLOGY

Reduced-Gliadin Wheat Bread: An Alternative to the Gluten-Free Diet for Consumers Suffering Gluten-Related Pathologies

(2014) Javier Gil-Humanes et al.   PLoS One

Quantitative and qualitative differences in celiac disease epitopes among durum wheat varieties identified through deep RNA-amplicon sequencing

(2013) Elma MJ Salentijn et al.   BMC GENOMICS

Targeted genome modification of crop plants using a CRISPR-Cas system

(2013) Qiwei Shan et al.   NATURE BIOTECHNOLOGY

Mutant Alleles of Photoperiod-1 in Wheat (Triticum aestivum L.) That Confer a Late Flowering Phenotype in Long Days

(2013) Lindsay M. Shaw et al.   PLoS One

Expansion of the gamma-gliadin gene family in Aegilops and Triticum

(2012) Svetlana V Goryunova et al.   BMC EVOLUTIONARY BIOLOGY

Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

(2012) Elma MJ Salentijn et al.   BMC GENOMICS

Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules

(2012) Ludvig M. Sollid et al.   IMMUNOGENETICS

Structural genes of wheat and barley 5-methylcytosine DNA glycosylases and their potential applications for human health

(2012) S. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-Regulating γ-Gliadins in Bread Wheat Leads to Non-Specific Increases in Other Gluten Proteins and Has No Major Effect on Dough Gluten Strength

(2011) Fernando Pistón et al.   PLoS One

In search of tetraploid wheat accessions reduced in celiac disease-related gluten epitopes

(2010) Hetty van den Broeck et al.   Molecular BioSystems

A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease

(2010) Cristina Mitea et al.   PLoS One

Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference

(2010) J. Gil-Humanes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease

(2010) Hetty C. van den Broeck et al.   THEORETICAL AND APPLIED GENETICS

Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines

(2009) Hetty C van den Broeck et al.   BMC PLANT BIOLOGY