Editorial Material
Gastroenterology & Hepatology
Jason A. Tye-Din
Summary: This article is related to the papers of Garzon-Benavides et al. To view these articles, visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Computer Science, Theory & Methods
Kelsey Harley, Rodney Cooper
Summary: The importance of integrity in information security has been traditionally underestimated but is crucial for our well-being. This review discusses information integrity through formal information flow models and the data modification view, as well as its relationship to data quality. While integrity protection is advancing, there is still a lack of standardization in terminology and application.
ACM COMPUTING SURVEYS
(2021)
Review
Biochemistry & Molecular Biology
Wided Najahi-Missaoui, Robert D. Arnold, Brian S. Cummings
Summary: The field of nanotechnology has rapidly grown over the past two decades, leading to the emergence of nanoparticles as promising tools in various applications. However, questions about the toxicity and safety of nanoparticles remain unanswered, despite efforts to understand them. Several approaches to minimize and prevent nanoparticle toxicity have been identified through research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Maha AlSendi, David O'Reilly, Youssef H. Zeidan, Catherine M. Kelly
Summary: Patients with metastatic breast cancer have seen significant improvements in survival recently. Treatment decisions for oligometastatic breast cancer vary widely due to lack of trials and disease heterogeneity. Research is ongoing to better understand the biology and treatment options for oligometastatic breast cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Gastroenterology & Hepatology
Marta Garzon-Benavides, Alfonso Rodriguez-Herrera, Carolina Sousa, Angeles Pizarro-Moreno
Summary: This article is associated with the papers by Garzon-Benavides et al. To access these articles, please visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Health Care Sciences & Services
Benjamin J. R. Buckley, Signe S. Risom, Maxime Boidin, Gregory Y. H. Lip, Dick H. J. Thijssen
Summary: Regular moderate-intensity exercise is recommended for preventing atrial fibrillation, and non-traditional exercises like yoga can also have positive effects on patient quality of life and physical capacity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Dany Perocheau, Loukia Touramanidou, Sonam Gurung, Paul Gissen, Julien Baruteau
Summary: Exosomes, a subset of extracellular vesicles, play a crucial role in cell-cell communication and have shown promising potential as diagnostic biomarkers and therapeutic carriers. Their reduced immunogenicity and ability to cross physiological barriers make them an appealing option for clinical application.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Lucy Perrem, Felix Ratjen
Summary: This study found that cross-species immune responses may take weeks or months to affect renal function after transplantation, indicating that the immune reaction in kidney transplantation is a long-term process. Additionally, the study also found that the transcriptional activation of immunity primarily occurs in innate immune cells rather than lymphocytes.
Review
Biochemistry & Molecular Biology
Aoife Reilly, Lucia Chehade, Rashmi Kothary
Summary: Spinal Muscular Atrophy (SMA) is a severe neuromuscular disease caused by the loss or deletion of the survival motor neuron 1 gene (SMN1). Significant advancements have been made in SMA therapeutics, improving the outcomes for patients. However, challenges and limitations still exist, necessitating further research for the best outcomes.
Review
Immunology
Benedict T. Bloom, Mary-Jessimine Bushell
Summary: Drug abuse is a global public health problem. Immunotherapy, particularly vaccines, has been studied as a treatment option for drug abuse. However, efficacy data do not support the use of vaccines for treating nicotine and cocaine abuse. Clinical trials are still needed to determine the effectiveness of vaccines against opioid abuse. Current treatments have limitations, highlighting the need for novel treatment strategies.
Article
Engineering, Electrical & Electronic
Rajeev Bansal
Summary: If the world were to self-destruct, the last sound we would hear would be an expert saying, "It can't be done."
IEEE MICROWAVE MAGAZINE
(2023)
Review
Clinical Neurology
Marie Dagonnier, Geoffrey A. Donnan, Stephen M. Davis, Helen M. Dewey, David W. Howells
Summary: Blood biomarkers have the potential to expedite diagnosis and increase eligibility for reperfusion therapies in acute stroke, but further research is needed to determine the optimal timing for early measurement.
FRONTIERS IN NEUROLOGY
(2021)
Editorial Material
Cell Biology
Jake Atkinson, Eva Bezak, Ivan Kempson
Summary: DNA double-strand breaks play a fundamental role in cell biology, but there is a lack of a reliable assay for quantitatively visualizing DSBs. Relying on proxy detection methods can lead to misinterpretation of conventional assays, highlighting the need for the development of more accurate DSB detection methods.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Charlotte Helmark, Alex Harrison, Susanne S. Pedersen, Patrick Doherty
Summary: Anxiety and depression are common in patients with ACS and are associated with poor outcomes. However, screening for these conditions in CR is inconsistent. This study identified determinants for screening at both patient and provider levels and recommended systematic screening to mitigate inequity in health outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Development Studies
Son Nghiem, Bach Tran, Clifford Afoakwah, Joshua Byrnes, Paul Scuffham
Summary: The history of humankind has witnessed a continuous improvement in living standards, but economic development has also had negative impacts on the environment and health. Technological progress is believed to help achieve a balance between health, income, and the environment. The study found evidence of convergence in emissions of carbon monoxide and nitrogen oxides, and emphasized the importance of improving human capital for the synergy between health, clean environment, and positive economic growth.
Article
Obstetrics & Gynecology
Caroline Atyeo, Lydia L. Shook, Nadege Nziza, Elizabeth A. Deriso, Cordelia Muir, Arantxa Medina Baez, Rosiane S. Lima, Stepan Demidkin, Sara Brigida, Rose M. De Guzman, Madeleine D. Burns, Alejandro B. Balazs, Alessio Fasano, Lael M. Yonker, Kathryn J. Gray, Galit Alter, Andrea G. Edlow
Summary: This study investigated the immune response to a COVID-19 mRNA booster dose in pregnant, lactating, and nonpregnant women. The results showed that receiving a booster dose during pregnancy induces a strong immune response and provides protection against variants such as Omicron. Boosting in the third trimester of pregnancy can increase the levels of maternal and neonatal immunity.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Correction
Infectious Diseases
Lael M. Yonker, Oluwakemi Badaki-Makun, Puneeta Arya, Brittany P. Boribong, Gabriela Moraru, Brittany Fenner, Jaimar Rincon, Alex Hopke, Brent Rogers, Jeremiah Hinson, Alessio Fasano, Lilly Lee, Sarah M. Kehoe, Shawn D. Larson, Hector Chavez, Scott Levin, Lyle L. Moldawer, Daniel Irimia
BMC INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
Jacopo Troisi, Martina Lombardi, Giovanni Scala, Pierpaolo Cavallo, Rennae S. Tayler, Steven J. K. Symes, Sean M. Richards, David C. Adair, Alessio Fasano, Lesley M. McCowan, Maurizio Guida
Summary: Metabolomic analysis may provide an important improvement in early prenatal screening for detecting fetal malformations. In this study, an ensemble machine learning model based on maternal serum metabolomic signatures showed a high diagnostic accuracy in detecting both chromosomal anomalies and structural defects. Further research is needed to identify specific types of malformations and confirm these findings on larger study populations.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pediatrics
Braden T. Tierney, James Versalovic, Alessio Fasano, Joseph F. Petrosino, Bruno P. Chumpitazi, Emeran A. Mayer, Jared Boetes, Gerard Smits, Shanthi G. Parkar, Noah Voreades, Ece Kartal, Gabriel A. Al-Ghalith, Marco Pane, Peter A. Bron, Gregor Reid, Raja Dhir, Christopher E. Mason
Summary: This study aimed to evaluate the efficacy of a synbiotic on increasing weekly bowel movements in constipated children. The results showed that treatment with the synbiotic increased the number of bowel movements in children with low baseline bowel movements, despite distinct baseline microbiome signatures. These findings suggest that multi-species synbiotic interventions may improve digestive health in pediatric population and that bioinformatics-based methods can predict response to microbial interventions in children.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Takumi Konno, Enid E. Martinez, Jian Ji, Alba Miranda-Ribera, Maria R. Fiorentino, Alessio Fasano
Summary: Zonulin is a physiological regulator of epithelial and endothelial permeability, and it plays a role in promoting antigen trafficking and chronic inflammatory diseases. A family of structurally and functionally related proteins called zonulin family proteins (ZFPs) was discovered, and two additional proteins, coagulation factor X (FX) and CD5 antigen-like (CD5L), were identified as potential new members of the ZFPs. These proteins exhibit similarities in structure and function with previously identified ZFPs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Lael M. Yonker, Zoe Swank, Yannic C. Bartsch, Madeleine D. Burns, Abigail Kane, Brittany P. Boribong, Jameson P. Davis, Maggie Loiselle, Tanya Novak, Yasmeen Senussi, Chi-An Cheng, Eleanor Burgess, Andrea G. Edlow, Janet Chou, Audrey Dionne, Duraisamy Balaguru, Manuella Lahoud-Rahme, Moshe Arditi, Boris Julg, Adrienne G. Randolph, Galit Alter, Alessio Fasano, David R. Walt
Summary: Blood samples from 16 patients who developed myocarditis after SARS-CoV-2 vaccination were analyzed for antibody and T-cell responses. The immune profiles of these patients were similar to those of vaccinated control subjects, except for the presence of free spike antigen in the blood of myocarditis patients.
Article
Biochemistry & Molecular Biology
Simone Di Micco, Veronica Di Sarno, Martina Rossi, Vincenzo Vestuto, Takumi Konno, Sara Novi, Mario Felice Tecce, Valeria Napolitano, Tania Ciaglia, Andrea Vitale, Isabel Maria Gomez-Monterrey, Giuseppe Bifulco, Alessia Bertamino, Carmine Ostacolo, Paolo Blasi, Alessio Fasano, Pietro Campiglia, Simona Musella
Summary: Different mechanisms contribute to cancer multidrug resistance, including increased drug efflux, enhanced cellular repair mechanisms, and alterations of drug metabolism or targets. ABCG2, a transporter protein, promotes drug efflux and causes chemotherapeutic resistance in malignant cells. Through a multidisciplinary approach, a new selective inhibitor (8) of ABCG2 has been identified, which effectively improves the cytotoxicity of mitoxantrone in hepatocellular carcinoma and transfected breast cancer cell lines. This inhibitor also demonstrates its efficacy in reversing multidrug resistance with the overexpression of the ABCG2 pump.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mariaconcetta Cariello, Angela Squilla, Martina Piacente, Giorgia Venutolo, Alessio Fasano
Summary: Extracellular vesicles (EVs), specifically exosomes, play a crucial role in the communication and information exchange between tumor cells and the tumor microenvironment (TME), as well as in the development of anti-cancer drug resistance (DR). The release of exosomes by cancer cells is triggered by the alteration of oxygen levels due to increased cancer cell proliferation. This review focuses on discussing the role and mechanism of exosomal miRNA in DR in hematological tumors, namely leukemia, lymphoma, and multiple myeloma. In conclusion, understanding the cargo of exosomes highlights their potential as targeted drug delivery vehicles, allowing for personalized therapy.
Article
Biochemistry & Molecular Biology
Birna Asbjornsdottir, Alba Miranda-Ribera, Maria Fiorentino, Takumi Konno, Murat Cetinbas, Jinggang Lan, Ruslan I. I. Sadreyev, Larus S. S. Gudmundsson, Magnus Gottfredsson, Bertrand Lauth, Bryndis Eva Birgisdottir, Alessio Fasano
Summary: The microbiota-gut-brain axis involves bidirectional communication between intestinal microbiota and various systems in the body, such as the gastrointestinal tract, central nervous system, and neuroendocrine/neuroimmune systems. This study investigates the effects of bovine colostrum administration on the intestinal microbiota and behavior in two mouse models and suggests its potential use in prophylactic approaches in the future.
Article
Multidisciplinary Sciences
Maureen Leonard, Victoria Kenyon, Francesco Valitutti, Rita Pennacchio-Harrington, Pasqua Piemontese, Ruggiero Francavilla, Lorenzo Norsa, Tiziana Passaro, Marco Crocco, Mariella Baldassarre, Chiara Maria Trovato, Alessio Fasano
Summary: The CDGEMM study is an international birth cohort study focusing on children at-risk of developing celiac disease (CD) and utilizing a multi-omic approach to predict CD onset. Participants are required to have a first-degree family member with biopsy diagnosed CD and be enrolled before solid food introduction. Longitudinal collection of blood, stool samples, and questionnaires related to participant, family, and environment has been ongoing since 2014. With a total of 554 participants and an average age of 56.4 months, the study has identified microbial strains, pathways, and metabolites associated with CD development. Ongoing analysis includes expanding metagenomic and metabolomic analyses, evaluating environmental risk factors, and investigating the role of microbiome and metabolites in CD development.
Correction
Multidisciplinary Sciences
Francesca Anna Cupaioli, Ettore Mosca, Chiara Magri, Massimo Gennarelli, Marco Moscatelli, Maria Elisabetta Raggi, Martina Landini, Nadia Galluccio, Laura Villa, Arianna Bonfanti, Alessandra Renieri, Chiara Fallerini, Alessandra Minelli, Anna Marabotti, Luciano Milanesi, Alessio Fasano, Alessandra Mezzelani
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Athanasios Beopoulos, Manuel Gea, Alessio Fasano, Francois Iris
Summary: Autism spectrum disorders (ASDs) are complex and highly heterogeneous neurodevelopmental disorders that are characterized by altered brain function. The exact pathogenesis of ASDs is still unclear, but it is believed to involve disruptions in neuronal migration and connectivity, as well as genetic and epigenetic factors. RNA epitranscriptomics, which affects the differential expression of proteins involved in central nervous system development, may play a prominent role in ASD pathogenesis.
FRONTIERS IN NEUROSCIENCE
(2023)
Letter
Cardiac & Cardiovascular Systems
Lael M. Yonker, Alessio Fasano, David R. Walt
Article
Dentistry, Oral Surgery & Medicine
Casey D. D. Wright, Brenda Heaton, Raul I. I. Garcia, Maureen M. M. Leonard, Alessio Fasano, Daniel W. W. McNeil
Summary: This study aimed to evaluate the potential role of gastrointestinal distress as a mediator between psychological stress and periodontal disease. The results showed that psychological stress was associated with gastrointestinal distress and self-reported periodontal disease. Gastrointestinal distress was also associated with self-reported periodontal disease and mediated the relation between psychological stress and periodontal disease.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Immunology
Chien-Wen Su, Chih-Yu Chen, Tangyou Mao, Ning Chen, Nicholas Steudel, Lefei Jiao, Jinggang Lan, Alessio Fasano, W. Allan Walker, Hai Ning Shi
Summary: This study aimed to determine the impact of maternal immunity and microbial factors on the induction and development of obesity in offspring. The results showed that maternal infection with helminths and the resulting changes in gut microbiota composition significantly reduced offspring obesity. Furthermore, supplementation of short-chain fatty acids to the pups of uninfected mothers protected against high-fat diet-induced weight gain.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)